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Monday, September 17, 2018

Longtime Tobacco Supplier Sees the Future in Cannabis


For a 145-year-old tobacco supplier, the future is in cannabis.
As Canada prepares to legalize marijuana next month, and regulations continue to loosen in the U.S. and other markets, Alliance One International Inc. is the latest company pivoting to pot.
With a valuation just north of $215 million, the North Carolina-based company is banking on the Canadian market to drive growth as tobacco cigarette smoking rates stagnate around the globe. The move comes as investors are pouring billions of dollars into the burgeoning industry, catapulting the value of cannabis stocks.
“Cannabis has been on our mind for some time,” Chief Executive Officer Pieter Sikkel said in an interview. “We could see that consumer tastes are changing.”
As part of its shift, Alliance is changing its name to Pyxus International Inc. as of Wednesday. The company historically has purchased, processed, packaged and shipped tobacco to cigarette manufacturers. It posted sales of $1.85 billion in its most recent fiscal year, returning to growth after three straight years of declines. It carries more than $900 million in debt.
As smoking rates decline, Alliance has been expanding into the market for tobacco vape products. And it now has stakes in two Canadian cannabis companies, in Ontario and on Prince Edward Island. Marijuana will be legal for recreational use by adults in Canada next month.

Constellation Move

Pot stocks have been on a tear since Constellation Brands Inc., the maker of Robert Mondavi wine and U.S. distributor of Modelo beer, announced it was boosting its stake in the Canadian company Canopy Growth, making a $3.8 billion investment. Alliance saw the power of cannabis to juice stock prices firsthand in February when its shares surged after it said it was entering the Canadian market. The stock has more than doubled over the past year.
The shares jumped 36 percent on Tuesday as the company prepared to update investors on its cannabis strategy. In addition to its new name, it changed its stock symbol to PYX.
While a handful of U.S. states allow recreational use, marijuana remains illegal on a federal level and the prohibition has kept many banks, big companies and institutional investors on the sidelines.
So far, the large tobacco companies have mostly stayed away. Universal Corp., an Alliance competitor, saw its shares fall last month when it stopped short of mentioning marijuana during an earnings call. Altria Group Inc., the tobacco giant that makes Marlboro for the U.S. market, said last week that while it intends to “continue to comply with federal law,” it was exploring options and was “mindful of the possibility that in the future cannabis may no longer be illegal under federal law.”
For tobacco companies, a move into cannabis might not be a slam dunk, according to Ken Shea, an analyst at Bloomberg Intelligence. Just as cigarette smokers are moving to non-combustible products like vape pens, cannabis users have embraced edibles and other forms of ingestion beyond smoking, he said. And the market for those products is very competitive, without the barriers to entry that have long boosted existing tobacco companies.
“The opportunity was obvious 20 years ago — you roll up cannabis in a joint and smoke it,” he said. “But smoking probably won’t be the main way people ingest cannabis. It’s declining for the same reason smokers are moving away from combustible devices.”

Bayer shopping 60% stake in Currenta to bidders


Bayer (BAYRY) has hired Morgan Stanley (MS) to shop its 60% stake in Currenta, which operates infrastructure facilities at German chemical complexes, according to Reuters, citing three people familiar with the matter. Currenta could be valued at more than $1.17B or possibly more, one of the sources said, according to Reuters
https://thefly.com/landingPageNews.php?id=2791403

Tandem Diabetes dip attributed to secondary lock-up expiration


Shares of Tandem Diabetes Care are trading lower, which is being attributed to the expiration of a lock-up related to a secondary offering of stock the company announced in August. On August 2, Tandem Diabetes announced a 3.51M share secondary offering of stock that priced at $28.50 per share and raised $100M. Today is the first day some shareholders and company insiders get to sell their shares in the healthcare safety device maker related to that secondary offering, according to Bloomberg data. In morning trading, Tandem dropped $6.54, or 13.7%, to $41.09 per share.

AmpliPhi Updates Positive Clinical Results for Expanded Access Program


AmpliPhi Biosciences Corporation (NYSE American: APHB), a clinical-stage biotechnology company focused on precisely targeted bacteriophage therapeutics for antibiotic-resistant infections, today announced updated topline clinical results for its ongoing single-patient expanded access program. 84% of patients achieved treatment success (physician’s assessment) at the end of therapy, defined as complete resolution or significant improvement of baseline signs and symptoms.
AmpliPhi has now provided its investigational bacteriophage therapeutics for a total of 21 patients, at 7 hospitals, with serious or life-threatening infections not responding to antibiotic therapy. These patients were treated with AB-SA01 or AB-PA01 under single-patient expanded access programs in the U.S. (Emergency INDs per the U.S. Food and Drug Administration) or Australia (Special Access Scheme per the Australian Therapeutic Goods Administration). The following analysis updates the data previously announced by the company on January 3, 2018:
  • 15 patients with serious S. aureus infections were treated with AB-SA01 and 6 patients with serious P. aeruginosa infections were treated with AB-PA01.
  • Infections in the treated patients included bacteremia, native and prosthetic valve endocarditis, recurrent pneumonia, ventilator-associated pneumonia, prosthetic joint infection, ventricular assist device infection, and others.
  • Over 1,000 bacteriophage doses were administered as part of the expanded access program including:
    • 400+ doses of AB-SA01, including 300+ doses administered intravenously. Treatment was well-tolerated in all patients with no treatment related serious adverse events (SAEs).
    • 600+ doses of AB-PA01, including 400+ doses administered intravenously. Treatment was well-tolerated in five patients. One patient discontinued treatment due to Grade 1 and 2 adverse events, which resolved within 18 hours. There were no treatment-related SAEs.
  • 84% (16 out of 19) of patients in the modified intent-to-treat population (mITT) achieved treatment success at the end of therapy. Treatment success, as determined by the treating physician, was defined as a complete resolution or significant improvement of baseline signs and symptoms. mITT population was defined as all patients who met the criteria for clinical diagnosis, whose bacterial isolate was susceptible to phage and who received at least one dose of phage.
“The encouraging results from AmpliPhi’s expanded access program support the view that phage therapeutics can be safely administered and provide anecdotal evidence of their efficacy, which we hope to soon demonstrate in randomized, controlled clinical trials,” said Dr. Jonathan Iredell, Senior Staff Infectious Diseases Physician at the Westmead Hospital in Sydney, Director of Centre for Infectious Diseases and Microbiology at the Westmead Institute of Medical Research and Professor of Medicine and Microbiology at the University of Sydney. “I look forward to helping bring this potentially important new modality to seriously ill patients, including those in whom usual treatment options are commonly inadequate.”

Arena Pharmaceuticals Has Preclinical Data at Pain World Congress


Arena Pharmaceuticals, Inc., Inc. (Nasdaq: ARNA) today announced that results from preclinical studies of its investigative drug candidate olorinab, a peripherally restricted, highly selective, full agonist of the cannabinoid receptor 2 (CB2) in development for the treatment of visceral pain associated with Crohn’s disease, were presented at the International Association for the Study of Pain (IASP) World Congress in Boston, MA.
“We are pleased to present data supporting olorinab’s antinociceptive effects in visceral sensory pathways,” said Preston Klassen, MD, MHS, Executive Vice President, Research and Development and Chief Medical Officer of Arena. “Through its full-agonism and selectivity, we believe olorinab may provide a novel therapeutic approach for sustained relief of visceral pain without psychotropic effects, potentially providing a new treatment option without the risk for dependence or abuse. We are currently evaluating olorinab in a Phase 2 clinical trial in IBD-associated abdominal pain and expect the availability of topline data by the end of the third quarter.”
Presentation Details
Poster Abstract Title: APD371, a Peripherally Restricted, Highly Selective, Full Agonist of the Cannabinoid Receptor 2 (CB2) Receptor, Reduces Colitis-Induced Visceral Hypersensitivity in Rats
Poster Number: PFR455
Presentation Date: Friday, September 14

Catasys Expands OnTrak-A Solution to Iowa, Neb. with Leading US Health Plan


Catasys Expands OnTrak-A Solution to Iowa and Nebraska with Leading National Health Plan
Source: Catasys, Inc. Multimedia Gallery URL
  • National Plan Expands OnTrak-A into 10th and 11th States
  • OnTrak-A Offered to Both Commercial and Medicare Advantage Plan Members
  • With This Launch, OnTrak Is Now Available in 22 States
Catasys, Inc. (CATS) (“Catasys” or the “Company”), a leading AI and technology-enabled healthcare company, today announced that it has expanded its OnTrak-A solution into Iowa and Nebraska with one of the nation’s leading health plans, which is the second largest plan in both states.
Eligible commercial and Medicare Advantage plan members in these states are now able to participate in OnTrak-A, an integrated 52-week program that identifies, engages and treats members with unaddressed behavioral health conditions that impact co-morbid medical conditions, such as diabetes, hypertension, coronary artery disease, COPD, and congestive heart failure, resulting in high medical costs. With this expansion, the OnTrak program is now available in 22 states to members of major health plans.
“This expansion demonstrates this national plan’s continued confidence in our ability to improve the health of their members and deliver savings to the national plan as they continue to roll us out into additional states,” said Rick Anderson, President and Chief Operating Officer of Catasys. “We look forward to assisting members in all 11 states where we are contracted with this partner to achieve better health and better lives.”
Catasys, Inc. harnesses proprietary big data predictive analytics, artificial intelligence and telehealth, combined with human intervention, to deliver improved member health and cost savings to health plans through integrated technology enabled treatment solutions. It is our mission to provide access to affordable and effective care, thereby improving health and reducing cost of care for people who suffer from the medical consequences of behavioral health conditions; helping these people and their families achieve and maintain better lives.
Catasys’ OnTrak solution–contracted with a growing number of national and regional health plans–is designed to treat members with behavioral conditions that cause or exacerbate co-existing medical conditions such as diabetes, hypertension, coronary artery disease, COPD, and congestive heart failure, which result in high medical costs.
Catasys has a unique ability to engage these members, who do not otherwise seek behavioral healthcare, leveraging proprietary enrollment capabilities built on deep insights into the drivers of care avoidance matched with data driven engagement technologies.
OnTrak integrates evidence-based medical and psychosocial interventions along with care coaching in a 52-week outpatient solution. The program is currently improving member health and, at the same time, is demonstrating reduced inpatient and emergency room utilization, driving a more than 50 percent reduction in total health insurers’ costs for enrolled members. OnTrak is available to members of several leading health plans in California, Connecticut, Florida, Georgia, Illinois, Iowa, Kansas, Kentucky, Louisiana, Massachusetts, Missouri, Nebraska, New Jersey, North Carolina, Oklahoma, Pennsylvania, South Carolina, Tennessee, Texas, Virginia, West Virginia and Wisconsin.

Cannabis stocks rise amid interest by Coca-Cola, opportunities for Shopify


Shares of cannabis stocks are in focus following a report that Coca-Cola (KO) is in talks with Aurora Cannabis (ACBFF) as it eyes the cannabis industry and an analyst note from Keybanc which said Shopify (SHOP) has cannabis potential. COCA-COLA EYES CANNABIS: Coca-Cola is monitoring the nascent cannabis drinks industry and is in talks with Canadian marijuana producer Aurora Cannabis to develop the drinks, Bloomberg reported Monday. “We are closely watching the growth of non-psychoactive CBD as an ingredient in functional wellness beverages around the world,” Coca-Cola spokesman Kent Landers said. “The space is evolving quickly. No decisions have been made at this time” Landers added. The move comes as beverage makers are looking towards cannabis as soda consumption and traditional business slows. Constellation Brands (STZ, STZ.B) previously announced it will spend $3.8B to increase its stake in Canadian marijuana producer Canopy Growth (CGC) and Molson Coors Brewing (TAP) is starting a joint venture with Quebec’s Hydropothecary to develop cannabis drinks. In addition, Diageo (DEO) has been holding talks with at least three Canadian cannabis producers regarding a potential deal and Heineken’s (HEINY) Lagunitas label has launched a brand focused on non-alcoholic drinks infused with THC. SHOPIFY MAY BENEFIT FROM CANNABIS SALES: KeyBanc analyst Monika Garb told investors in a research note on Monday that she is a buyer of Shopify, as the company has “ample” growth opportunities ahead. She sees potential upside to her above-consensus estimates and expects that recreational sales of cannabis in Canada could be a general merchandise volume and revenue driver further benefiting Shopify’s business momentum. The analyst said the company has been selected by several Canadian provinces to run their e-commerce sites and in-store point of sale solutions and has also signed deals with private cannabis producers and distributors, including Canopy Growth and Aurora. Additionally, Garb says Shopify is the best positioned to benefit from growth in emerging brands, citing brands like Rebecca Minkoff and Kyle Cosmetics that already use Shopify. Garb maintained an Overweight rating and $182 price target on shares. CANNABIS STOCKS: Publicly-traded companies in the space include Cronos Group (CRON), Canopy Growth, Tilray (TLRY), Cannabis Science (CBIS), Innovative Industrial Properties (IIPR) and Aurora Cannabis. PRICE ACTION: Aurora Cannabis gained over 16% in morning trading, while Tilray gained 7.3%.