Cancer Detection and Positive Predictive Value Substantially Higher Than the Previously Published PATHFINDER Study
GRAIL, Inc. (Nasdaq: GRAL), a healthcare company whose mission is to detect cancer early when it can be cured, today announced positive top-line performance and safety results from the pre-specified analysis of the first 25,578 participants in GRAIL's registrational PATHFINDER 2 study. PATHFINDER 2 was initiated in 2021 to evaluate the safety and performance of the Galleri® multi-cancer early detection (MCED) test when added to standard of care single cancer screening in 35,878 adults over 50 years of age with no clinical suspicion of cancer.
In the previously published PATHFINDER study, adding Galleri to standard of care cancer screening more than doubled the overall number of cancers detected by screening. In PATHFINDER 2, adding Galleri to standard of care screening demonstrated substantially greater additional cancer detection than in PATHFINDER.
In PATHFINDER, Galleri demonstrated a positive predictive value (PPV), or likelihood that a positive Galleri test was confirmed to be cancer, of 43%; specificity of 99.5%; and 88% cancer signal origin (CSO) accuracy. Data from evaluable PATHFINDER 2 participants with 12 months of follow-up showed a substantially higher PPV than that observed in the PATHFINDER study. CSO accuracy and specificity were consistent with that observed in the PATHFINDER study.
There were no serious safety concerns reported in PATHFINDER 2.
Homeland Security Secretary Kristi Noem was hospitalized “out of an abundance of caution” due to an allergic reaction Tuesday, a DHS spokesperson said.
Noem, 53, was brought to a hospital in Washington, DC, and is “alert and recovering,” the Department of Homeland Security official said.
Noem was back in Washington after a trip to LA amid the riots.REUTERS
Sources familiar with the matter told The Post that Noem specifically requested an ambulance to take her to the hospital.
It is unclear what sparked the allergic reaction.
Multiple Secret Service agents were stationed outside of the emergency room where Noem was admitted, CNN reported.
Noem was tapped by President Trump to lead the DHS mere days after he clinched his second term victory in November and she was confirmed by the Senate in January.
As DHS chief, Noem has been at the forefront of Immigration and Customs Enforcement’s unrelenting crackdown on illegal immigrants that sparked nationwide protests, including over a week of chaos in Los Angeles.
Noem has even joined federal agents on some raids across the US, including the first of the New Year in New York City just days after being confirmed as the Secretary of Homeland Security.
On Wednesday morning, Noem was expected to appear in New York City for a press conference about the implementation of REAL ID at airports nationwide alongside members of the Transportation Security Administration.
But in the wake of her hospitalization, the press conference was postponed.
Oracle has released its new cloud-based offering, Oracle Health Community Care, for caregivers to access patient charts.
The new technology is a mobile extension of the Oracle Health Foundation electronic health record (EHR) and also enables caregivers to securely update the comprehensive charts irrespective of network connectivity and location.
Therapists, nurses, social workers, dieticians and physicians have the necessary information for conducting in-home patient visits, carrying out emergency interventions and delivering care in mobile clinics.
Oracle's health and life sciences executive vice-president and general manager Seema Verma said: “With Oracle Health Community Care, we are delivering comprehensive patient health records to caregivers in the field, so they have the information they need to provide quality care anytime, anywhere.”
Oracle Health Community Care empowers clinicians to access up-to-date patient chart details and document encounters offline, ensuring a comprehensive approach to care.
This feature synchronises information added to the patient record while offline with the EHR once network connection is restored.
When patients transition from hospital to home-based care, for instance, Oracle Health Community Care allows clinicians to download the latest patient information securely from the Oracle Health Foundation EHR through a mobile device. This ensures continued access to records.
Clinicians can then update the patient record during home visits and sync the data with the EHR, allowing the entire care team to access near-real-time updates on patient care activities.
The solution also allows for the documentation of patient assessments, orders, and changes in condition in the mobile app directly.
This immediate access to critical information facilitates the delivery of tailored care that meets the specific requirements of each patient.
Oracle Health Community Care collaborates with mapping applications on mobile devices, enabling practitioners to access information about neighbourhoods and patients' residences to facilitate in-home visits.
It also provides communication features, enabling practitioners to call or message the primary care provider of the patient.
Last September, Oracle expanded its healthcare offerings with the introduction of an RFID [radio-frequency identification] for Replenishment solution within its Oracle Fusion Cloud supply chain and manufacturing (SCM) suite.
"Oracle releases cloud-based technology for caregivers" was originally created and published by Hospital Management, a GlobalData owned brand.
A California appeals court upheld a verdict ordering a Los Angeles County school district to pay$1 million to a former student who was the target of a relentless, months-long bullying campaign that included death threats.
On Friday, the El Segundo Unified School District in Los Angeles County lost its appeal of a 2022 court decision that found the district negligent in protecting Eleri Irons from “bullying, tormenting, and aggression.”
Irons, now 21, was a 13-year-old student at El Segundo Middle School when other teens began bullying her between November 2017 and June 2018.
Eleri Irons with her attorneys after the appeals court’s decision on June 13, 2025.ACTS LAW
The school district’s appeal focused on several issues, claiming Irons failed to prove any of her injuries and that it wasn’t responsible for how employees handled the issue.
The school’s lawyers also cited a state government code that removes public employees from all liability, according to Patch.
Irons “suffered PTSD, cut herself and sought refuge in the school nurse’s office nearly every lunch break” over the intense bullying, the 2019 lawsuit stated.
The harassment began after Irons’ friendship with two classmates ended because of a love triangle.
The two girls allegedly brought in a third teen as the bullying and torment spiraled.
Irons was called “a liar, whore, cheater and boyfriend-stealer, flipped her off and made fun of her in the hallways, and even slapped her in the face. They screamed at her in person and harassed her online,” Today reported.
Irons “suffered PTSD, cut herself and sought refuge in the school nurse’s office nearly every lunch break” over the intense bullying, the 2019 lawsuit stated.Christa Haggai Ramey
The teen was the target of a months-long campaign of verbal harassment and cruel rumors leading up to a petition spreading around the school titled “End the Life of Eleri Irons,” her attorneys from ACTS Law said.
“This ruling confirms what the jury already knew: Eleri was failed at every level by the very people who were supposed to protect her,” attorney Christa Ramey said after the ruling.
“Instead of taking accountability and supporting this young woman’s recovery, the district chose to spend taxpayer money fighting her in court for years. That’s not leadership. That’s cowardice.”
Ramey denounced the school district’s appeal as it prolonged the case, forcing the young woman to continue reliving “one of the most traumatic periods of her life.”
School officials were first made aware of the cruel attacks when teachers learned about the petition, but didn’t stop it.
Irons’ parents approached the school’s principal, who allegedly lied about calling police as soon as she learned of the death threat in June 2018.
School officials were notified of the bullying Irons faced by her and her family, but failed to respond to the claims.
“Despite being aware of the threats, school officials failed to take meaningful action, failed to notify her parents, and failed to follow their own anti-bullying policies,” Irons’ lawyers said.
Melissa Gooden served as the El Segundo Middle School principal.El Segundo Unified School District
Irons’ parents confronted the alleged bullying, but school officials dismissed the concerns “as drama over a teen love triangle,” Ramey told the LA Times in 2022.
A Los Angeles jury found that the school district failed to safeguard Irons from three bullies who were the leaders of the campaign.
The three bullies were suspended for their bullying.
The school district said it would “do the right thing” after the 2022 verdict was reached. It has not publicly addressed the appeals court ruling.
Irons forgave her bullies during an interview in 2018.
“I forgive them,” Irons told Today. “I always wanted to give them the benefit of the doubt because I (once) valued their friendship. They didn’t get the intervention they needed either. The school failed me and them.”
AbbVie (NYSE: ABBV), a prominent player in the biotechnology industry with a market capitalization of $327.63 billion and annual revenue of $57.37 billion, announced Wednesday that its migraine prevention drug atogepant demonstrated superior tolerability and efficacy compared to topiramate in a Phase 3 head-to-head clinical trial.
The TEMPLE study, which evaluated 545 adults with four or more migraine days per month, met its primary endpoint with significantly fewer patients discontinuing atogepant due to adverse events (12.1%) compared to topiramate (29.6%) over the 24-week treatment period.
The trial also showed superior efficacy for atogepant, with 64.1% of patients achieving at least a 50% reduction in monthly migraine days versus 39.3% for topiramate. All six secondary endpoints demonstrated statistical significance favoring atogepant.
Scholar Rock (NASDAQ: SRRK) saw a substantial premarket stock increase of nearly 14% following the announcement of successful trial results. The company's experimental drug, apitegromab, when combined with Eli Lilly's tirzepatide, showed enhanced weight loss effects while maintaining significant lean body mass compared to tirzepatide usage alone. This promising development has captured the attention of investors and analysts alike.
Ekso Bionics (NASDAQ: EKSO) has demonstrated initial proof-of-concept for integrating AI capabilities into their medical and industrial exoskeleton devices, following their recent acceptance into the NVIDIA Connect Program. The company has developed an AI voice agent for their EksoNR device, implemented using NVIDIA Jetson Orin Nano hardware, NVIDIA JetPack SDK, and OpenAI tools. The Edge AI system can operate with or without cloud connectivity. Ekso Bionics leverages a substantial database of approximately 350,000 patient sessions and over 15 million step-by-step data points, growing by about 60,000 patient steps daily, positioning them uniquely to advance exoskeleton technology through AI integration.
