Neuropilin-1 (NRP1) as novel SARS-CoV-2 host cell entry mediator implicated in COVID-19

 

Ioannis Kyrou, 

Harpal S. Randeva, 

Demetrios A. Spandidos &

 

Emmanouil Karteris

DOI: https://doi.org/10.1038/s41392-020-00460-9

PDF: https://www.nature.com/articles/s41392-020-00460-9.pdf

Two recently published studies published in Science by Daly et al.1 and Cantuti-Castelvetri et al.2 identified neuropilin-1 (NRP1) as an additional cellular mediator which may facilitate the entry of the new severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 (SARS-CoV-2) into host cells. The findings of these elegant studies collectively indicate that, in addition to the role of angiotensin-converting enzyme 2 (ACE2) in mediating the cellular entry of SARS-CoV-2, NRP1 may act as a host cell mediator that can increase the infectivity and may thus contribute to the tissue/organ tropism of this coronavirus.

https://www.nature.com/articles/s41392-020-00460-9