Positive Clinical Data on Axcella’s AXA1665 Candidate for Overt Hepatic Encephalopathy

 Activity demonstrated across targeted biologies, including amino acid balance, ammonia handling, muscle function and neurocognition

Presentation includes new subject-specific neurocognition and muscle function data

Axcella (Nasdaq: AXLA), a clinical-stage biotechnology company pioneering a new approach to treat complex diseases and improve health using endogenous metabolic modulator (EMM) compositions, today announced that positive data from the company’s AXA1665-002 clinical study were presented last night at the Digestive Disease Week (DDW) 2021 Annual Meeting by Dr. Arun Sanyal, Professor in the Virginia Commonwealth University (VCU) Department of Internal Medicine and Education Core Director in the VCU Center for Clinical and Translational Research.

AXA1665-002 was a placebo-controlled, randomized clinical study that investigated the safety, tolerability and physiological impact of AXA1665 in 60 subjects with mild (Child Pugh A) and moderate (Child Pugh B) hepatic insufficiency. Subjects in the study were randomized in a 2:2:1 ratio to receive either 29.4 g or 53.8 g of AXA1665 or a matched placebo in three divided doses per day for 12 weeks with a four-week follow up.

https://finance.yahoo.com/news/positive-clinical-data-axcella-axa1665-112800219.html