Alterity Therapeutics (NASDAQ: ATHE) has announced the publication of a groundbreaking study in the Annals of Clinical and Translational Neurology, introducing the MSA Atrophy Index (MSA-AI), a novel MRI-based measurement tool for Multiple System Atrophy (MSA).
The research, developed through Alterity's bioMUSE Natural History Study, employs deep learning methods to track brain atrophy in MSA patients. The study demonstrated that MSA-AI can effectively distinguish MSA from related conditions like Parkinson's disease and Dementia with Lewy Bodies, with significantly lower scores indicating reduced brain volumes in MSA patients (p < 0.001).
Importantly, the study revealed that 12-month brain volume reductions correlated with clinical disease worsening. This innovative tool will be implemented in Alterity's Phase 2 clinical program and future Phase 3 trials for patient selection and disease progression monitoring.
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