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Thursday, July 25, 2019

AstraZeneca raises sales forecast after second quarter cancer drug, China boost

AstraZeneca Plc raised its product sales forecast for 2019 on Thursday after second-quarter results beat analysts’ expectations, thanks to strong sales from cancer medicines and emerging markets, especially China.

The British drugmaker’s shares rose more than 6% to hit a record high of 6,770 pence by 1001 GMT, bringing gains for the year so far to around 14% as Chief Executive Officer Pascal Soriot’s turnaround plan gained traction.
AstraZeneca, which maintained its dividend, reported a rise in drug sales for the fourth consecutive quarter after posting years of decline in sales due to patent losses on older drugs.
“The momentum generated last year continued into the first half, consolidating AstraZeneca’s return to growth based on the strength of our new medicines,” Soriot said. “We are very optimistic for the next few quarters.”
Sales from its oncology unit soared 57% to $2.17 billion (£1.74 billion), accounting for 38% of total product sales, with revenue from the company’s top-seller – lung cancer drug Tagrisso – nearly doubling to $784 million.
The company has moved deeper into cancer therapy through wide-ranging deals, including those for immunotherapy and targeted therapy. Earlier this year, it agreed a multi-billion dollar oncology deal with Japan’s Daiichi Sankyo Co.
AstraZeneca’s focus on China has also resulted in explosive growth, with sales more than doubling since 2012 on the back of partnerships with local players and a softening of the regulatory environment for pharmaceutical firms.
Chinese sales rose 44% in the three-month period to $1.17 billion, accounting for more than half of its sales in the developing world.

The drugmaker, however, has warned that growth may not be sustainable.
“We are very pleased with overall performance of China,” Ruud Dobber, executive vice president, BioPharma, told Reuters, but added the company still expected changing policies in the country to hurt sales of its cholesterol drug, Crestor.
AstraZeneca said it now expects full-year product sales to increase by a low double-digit percentage, compared to a previous forecast of high single-digit percentage growth but it maintained its forecast for 2019 core earnings.
Quarterly sales rose 19% to $5.72 billion at constant currency, above analysts’ consensus of $5.45 billion.
Core earnings were 73 cents per share, beating analysts’ average expectation of 61 cents per share, according to a company provided consensus.
Like other players, AstraZeneca has been one of the focal points for concern over supplies of drugs if Britain leaves the European Union without a withdrawal deal later this year.
The company reiterated on Thursday that it was prepared for the breakup, even if it was a no-deal exit.
“We are as ready as we can be,” Soriot added.

Vanda cut to Hold from Buy by Stifel

Target to $17 from $26

Boston Scientific target upped to $50 from $48 by Raymond James

Maintains Strong Buy

Alexion target upped to $168 from $164 by Raymond James

Maintains Outperform

Matinas up 12% premarket on accelerated review status for MAT2203

The FDA has designated Matinas BioPharma’s (NYSEMKT:MTNB) MAT2203 a Qualified Infectious Disease Product for Fast Track review for the three new indications: the prevention of invasive fungal infections due to immunosuppressive therapy, treatment of invasive candidiasis and treatment of invasive aspergillus.
MAT2203 is a lipid crystal nanoparticle formulation of the broad spectrum anti-fungal agent Amphotericin B. Its value proposition is less side effects, particularly less renal toxicity, compared to currently available versions.
Shares are up 12% premarket on increased volume.

Castle Biosciences prices IPO at upper end of range

Castle Biosciences (CSTL) has priced its IPO of 4M common shares at $16, for gross proceeds of ~$64M.
The shares are expected to begin trading today on Nasdaq  under the symbol “CSTL.”
Closing date is July 29.
Underwriters over-allotment is an additional 0.6M common shares.
Source: Press Release

Livongo prices IPO at $28, above high end of range

Livongo Health (LVGO) has priced its IPO of 12.69M common shares at $28 for total gross proceeds of approximately $355.2M.
Underwriters over-allotment is an additional 1.9M common shares.
The shares are expected to begin trading today on Nasdaq under the symbol “LVGO”
Closing date is July 29.
Source: Press Release