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Sunday, August 30, 2026

Bessent says US plans weekly Iran sanctions, starting with banks

 

The US Treasury plans to impose new secondary sanctions related to Iran every week, beginning with banks, Treasury Secretary Scott Bessent told Reuters.

“We’re telling banks it’s not OK to have Iranian money and to aid the Iranian regime,” Bessent said.

He rejected the argument that Washington’s pressure campaign could succeed only if it imposed secondary sanctions on Chinese companies, saying the US blockade of Iranian ports had already curbed Chinese imports of Iranian oil.

https://www.iranintl.com/en/202608302689

Man from Supreme Leader's empire takes the helm of Iran’s biggest online retailer

 Two years ago the editor of Iran's most hardline newspaper said management of the country's biggest online retailer would "fortunately" pass to those who serve the state. It is now chaired by a former spokesman for the supreme leader's business empire.

Hojjat Niki-Maleki identifies himself on LinkedIn as chairman of Digikala Group, having joined the board as a representative of Harakat Aval, the investment arm of the mobile operator MCI. An official company filing lists him as a board member without specifying the chairmanship.

The change dates to June 10 but became public only when the formal notice was published this week, according to the Iranian technology outlet Digiato.

Niki-Maleki previously headed communications for the Execution of Imam Khomeini's Order, commonly known as Setad, a conglomerate built largely on property confiscated after the 1979 revolution, controlled by the office of the supreme leader and under US sanctions. He also spent more than four years on MCI's board.

Hojjat Niki-Maleki

His earlier work was in hardline media. He ran Afsaran, an online platform that promoted anti-Western messaging and the authorities' concept of a cultural "soft war."

His social media history also shows an affinity with the military establishment: in January 2020 he posted a photograph of himself seated beside Qasem Soleimani, then commander of the Revolutionary Guards' Quds Force, on an aircraft.

"I told him I was the son of a martyr, and his respect for me doubled," he wrote, describing Soleimani embracing him at an airport. "The sweet taste of my conversation with Haj Qasem is still with me."

Hojjat’s father, Hossein Niki-Maleki, was a member of the security team aboard Iran Air Flight 655, which was shot down by the United States in 1988.

A social media post by Hojjat Niki-Maleki shows him seated next to Qassem Soleimani on a plane.

Boycott calls

The appointment prompted calls on Persian-language social media to stop shopping at Digikala, with critics pointing to his Setad connection, his politics and his role promoting Iran's domestic Covid-19 vaccine.

"Do not buy from Digikala. This is something you can do," one user wrote on X, arguing that purchases would ultimately help finance Revolutionary Guards missiles and drones.

Another framed the appointment as part of a wider expansion of state-linked influence over the company.

Workers handle packages at a Digikala warehouse in Iran.

Much of the criticism returned to the vaccine. Niki-Maleki worked for Setad when its pharmaceutical arm developed CovIran Barekat, the domestically produced Covid-19 vaccine that authorities promoted during the pandemic, and he repeatedly used his own accounts to publicize its production and effectiveness.

That program became politically charged after the late Supreme Leader Ali Khamenei barred imports of American and British vaccines in January 2021. Critics argued that relying on domestic production delayed access to sufficient doses while Iran struggled to vaccinate its population, and some hold the officials who promoted it responsible for deaths that followed, a charge they have never accepted.

"He used to come here every day two years ago and hashtag that there would soon be good news and we would make a coronavirus vaccine," one user wrote.

About 150,000 people died from the pandemic across Iran, one of the heaviest official tolls in the region. Turkey, with a population of similar size, recorded roughly 100,000. Saudi Arabia reported fewer than 10,000 and the United Arab Emirates around 2,400. What each of those countries did have was early access to Western vaccines, the ones Iran's Supreme Leader had ruled out.

Hojjat Niki-Maleki receives a COVID-19 vaccine during a clinical trial in Iran.

A pattern, not an appointment

The reaction reflects something larger than one board seat: a sequence of events that has moved Iran's most prominent private technology company steadily closer to the state.

Digikala was founded in 2006 by the brothers Hamid and Saeid Mohammadi and grew into the country's dominant online marketplace, the most recognizable business to emerge from Iran's private technology sector.

The pressure began in the summer of 2023, when police sealed its offices after photographs circulated of female employees without compulsory hijab.

In February 2024, the judiciary filed charges over products it said insulted Islamic sanctities, after users circulated images of mugs sold on the site bearing the name Fatemeh Zahra, the daughter of the Prophet Mohammad. The company's chief executive, Masoud Tabatabai, was arrested on the order of the security prosecutor's office and released hours later pending further appearances. Pro-government vigilantes painted threatening messages on the company's building.

That same month, Hossein Shariatmadari, editor of Kayhan and Khamenei's representative at the newspaper, said management of digital companies such as Digikala and the ride-hailing platform Snapp would "fortunately" be transferred to those "who serve the state."

Negotiations over a stake in Digikala also began in that period. They concluded this spring, when Harakat Aval, MCI's venture capital arm, bought 40 percent of Digikala Group in cash, taking over the holding of the venture firm Sarava Pars along with parts of other shareholdings.

The agreed valuation was 300 trillion rials, about $146 million at current market rates, in what the company called the largest investment in the history of Iran's digital economy.

Digikala said the founders would retain 22 percent and two of five board seats, along with executive management, business strategy and the selection of senior managers, and that no single shareholder would control the company.

MCI's own ownership is the point critics return to. Iran's largest mobile operator is a subsidiary of the Telecommunication Company of Iran, privatized in 2009 in a sale to a consortium widely reported to be linked to the Revolutionary Guards.

Niki-Maleki's appointment points to a wider shift in Iran's digital economy: the steady expansion of state-linked institutions into businesses built as private enterprises – which is also why a prediction made in a hardline newspaper in 2024 reads today less like a threat than a schedule.

https://www.iranintl.com/en/202608273589

US says Larak attack targeted ‘imminent threat’ to Hormuz

 

US Central Command said Sunday’s attack on IRGC forces on Larak Island targeted an “imminent threat” to the Strait of Hormuz, rejecting Tehran’s characterization of the strike as an “act of aggression.”

CENTCOM said US forces took “limited, precise action” against Revolutionary Guards forces attempting to lay mines in the Strait.

“Iran created the threat and the US military eliminated it,” CENTCOM said, adding that the strike was intended to protect civilian mariners, commercial shipping and the flow of global commerce.

https://www.iranintl.com/en/202608318011

ESC: Arrowhead Phase 3 SHASTA-3, -4 Data Demonstrate Plozasiran Reduced Acute Pancreatitis

  Plozasiran reduced triglycerides (TG) by 79% and 81% versus placebo in SHASTA-3 and SHASTA-4 across the broad sHTG population -

- More than 90% of plozasiran-treated patients achieved triglycerides below thresholds for AP risk, 500 mg/dL at Month 12, and more than half achieved triglycerides below 150 mg/dL -

- Plozasiran reduced cumulative acute pancreatitis (AP) events by 78% versus placebo in patients with TG above 500 mg/dL, with or without a prior history of AP -

- Greater absolute benefit of AP risk reduction was observed in patients at higher risk -

- In the highest-risk subgroup, patients with TG above 880 mg/dL and a prior history of AP, there was a 100% reduction in events versus placebo -

- Plozasiran demonstrated a favorable safety and tolerability profile, with overall treatment-emergent adverse events similar between plozasiran and placebo groups -

- Arrowhead plans to file a supplemental New Drug Application with the U.S. FDA by year-end 2026 and utilize a Priority Review Voucher -

- Detailed results presented at the European Society of Cardiology (ESC) Congress 2026 in Munich as a Hot Line Late-Breaking Science session -

https://ir.arrowheadpharma.com/news-releases/news-release-details/arrowhead-pharmaceuticals-presents-phase-3-shasta-3-and-shasta-4

Alnylam New Data at ESC Backs RNAi-Powered TTR Silencing Across ATTR-CM Patients

 Late-Breaking Prespecified Subgroup Analysis of HELIOS-B Demonstrates that Vutrisiran Provided Consistent Clinical Benefit Across All-Cause Mortality and Recurrent Cardiovascular Events in Patients With or Without Tafamidis Use at Baseline –

Additional Post Hoc Analyses Highlight Positive Impact of Vutrisiran in Addressing the Multisystemic Manifestations of ATTR-CM –

Pooled Analysis Across Four Positive Phase 3 Studies of Vutrisiran and Patisiran Shows Consistent Treatment Effect Across Sexes –

New Subgroup Analysis from KARDIA-3 Phase 2 Study of Zilebesiran Highlights Potential to Provide Enhanced Blood Pressure Control –


https://investors.alnylam.com/press-release?id=30006

Bayer, AskBio Presents Baseline Characteristics from Phase 2 Heart Failure Study at ESC

 Phase 2 GenePHIT trial successfully randomized and completed enrollment of one of the largest gene therapy trials conducted in heart failure to date, with more than 170 participants randomized across 64 sites in 12 countries1 / Baseline characteristics demonstrate successful enrollment of a well-characterized population of patients with non-ischemic heart failure with reduced ejection fraction (HFrEF) / Initial efficacy and safety outcomes from GenePHIT are expected in the first half of 2027

https://www.bayer.com/media/en-us/askbio-presents-baseline-characteristics-from-phase-2-heart-failure-gene-therapy-trial-of-umiposgene-parvec-ab-1002-at-european-society-of-cardiology-congress/

United Therapeutics highlights new data supporting two FDA filings

 

United Therapeutics (UTHR) presents Phase 3 data on ralinepag and inhaled treprostinil at EU congresses, as FDA reviews PAH/IPF filings