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Friday, June 12, 2026

Cardiovascular diseases biotech Kardigan sets terms for $350 million IPO

 Kardigan, a Phase 2b/3 biotech developing therapies for cardiovascular diseases, announced terms for its IPO on Thursday.


The Princeton, NJ-based company plans to raise $350 million by offering 23.3 million shares at a price range of $14 to $16. At the midpoint of the proposed range, Kardigan would command a fully diluted market value of $1.6 billion.

Kardigan is advancing three late-stage product candidates: danicamtiv, an oral cardiac myosin activator in a Phase 2b/3 trial for genetic dilated cardiomyopathy caused by MYH7 and TTN gene variants; ataciguat, an oral soluble guanylate cyclase activator in a Phase 2b trial targeting calcific aortic valve stenosis progression; and tonlamarsen, a subcutaneous antisense oligonucleotide administered once monthly that targets hepatic angiotensinogen for blood pressure management in post-hospitalization acute severe hypertension. Kardigan also operates the Prolaio platform, a proprietary data and analytics system incorporating FDA-cleared algorithms and wearable sensor integration designed to collect continuous real-world physiologic data from patients during clinical trials.

Kardigan was founded in 2023. It plans to list on the Nasdaq under the symbol KARD. J.P. Morgan, Jefferies, Leerink Partners, and TD Cowen are the joint bookrunners on the deal. It is expected to price the week of June 15, 2026.

Pushy NHS chatbots 'can put patients off screening'

 Amid the push to digitise the UK health service, a study has sounded a note of caution about entrusting important patient appointments to chatbots.

In a paper published in the journal Lingua, researchers at the University of Surrey polled 300 patients who used a chatbot called Asa to book a cervical cancer screening test, which revealed that the manner in which an AI assistant communicates matters as much as what it does.

While the patients tended to respond positively to friendliness and choice-oriented language, they were put off by "over-messaging, pushy reminders, and blurred human-AI boundaries," according to the team, led by Dr Doris Dippold, associate professor of intercultural communication at the University of Surrey.

"Our analysis shows that anthropomorphism is not universally positive," said Dippold. "Human-like features can build rapport – but when they clash with patients' expectations for transparency in a healthcare setting, they undermine exactly the trust the chatbot is trying to build."

Understanding why that can occur is important, particularly as cervical screening uptake across the UK fell more than 5% in 2023-24, with ethnic minority groups consistently underrepresented in screening programmes – something that Asa was specifically designed to overcome. And doubly so, given the likelihood that AI assistants are likely to become an increasingly common component of NHS delivery, now that the UK government has made digital engagement a pillar of its health reforms.

Developed by SPRYT with funding from pharma company MSD, Asa was the first WhatsApp and AI-based appointment scheduling app to be approved for use by the NHS after a successful pilot at the NHS North Central London Integrated Care Board (ICB).

That chatbot is designed so patients can interact with it as they would with a human receptionist, and allows them to book, reschedule, and cancel appointments via WhatsApp at any time, without requiring a new app or website.

The Surrey study found that, on the whole, Asa users described the chatbot positively, using terms like "friendly", "kind", and "not forceful", with some reporting that the female persona presented by the AI made it easier to disclose sensitive information, such as needing to cancel an appointment due to menstruation. Asa was also seen to provide anonymity benefits in a sensitive health domain.

However, the research also uncovered what the researchers call "friction points," noting that "many patients found follow-up messages sent within 24 hours intrusive, and described imperative phrasing such as 'Let's book you in' as aggressive, rather than helpful." Those perceptions tended to be exacerbated for patients managing mental health challenges, neurodivergent conditions, or demanding caring responsibilities.

Patients also disliked a lack of dialogue opportunities with Asa, for example, when the AI did not respond to queries or did not offer opportunities to ask questions.

At the same time, many of the respondents said they had ethical concerns about the use of Asa, including data security, impersonation, and anthropomorphic features that blurred the boundaries between human and AI.

Chatbots should be designed with several key considerations, beyond simply helping patients achieve a goal. A feeling of control over decisions is critical, as is the chatbot's ability to respond appropriately, strike a respectful tone, ensure fairness, and – crucially – be transparent about the underlying technology.

"Feeling seen, appreciated, and emotionally supported is not a luxury feature in health AI - it is a condition of access," said Dippold. "If patients disengage because a chatbot feels pushy or untrustworthy, the health service loses them entirely."

https://pharmaphorum.com/news/pushy-nhs-chatbots-can-put-patients-screening

UK offers meningitis jab to young people after outbreak

 The UK government has responded to calls to broaden vaccinations for meningitis B (MenB), saying it will offer two doses of GSK's Bexsero shot to up to young people aged under 25.

The one-off immunisation campaign comes after the largest-ever UK outbreak in Kent earlier this year, which resulted in two deaths, as well as unusual clusters of cases in Dorset and Berkshire. MenB has a fatality rate of around 10% and can also result in life-changing disabilities such as amputations, hearing loss, and brain damage.

Vaccination with Bexsero has been available through the NHS for all infants since 2015, but there remains a large population of young people who remain unvaccinated. Until now, extending immunisation to older young people has not been deemed cost-effective, in part because it does not stop the infection from being transmitted, although it does reduce the risk of severe symptoms.

To address that shortfall, the NHS will offer the vaccine to all Year 13 pupils – typically aged 17 – as well as anyone under 25 starting university or residential further education for the first time this autumn. The first dose will be offered from July, and the second in August, to get ahead of the usual September intakes.

The Department of Health and Social Care (DHSC) said Bexsero will be offered to "thousands" of young people, with some estimates saying the eligibility could be as high as a million. The jabs will also be available to international students, although, DHSC said they "should receive their first dose in their home country where possible."

Health Secretary James Murray said the action was taken because the recent cases indicate a possible change to the way MenB affects people.

"While we assess the latest evidence, we are acting now to help protect young people at highest immediate risk," he added, alluding to data that suggests that the relative risk of invasive MenB disease in first-year university students is substantially greater than in their peers.

"I urge all those students who are eligible to come forward for their two doses […] to give them peace of mind as they head off to continue their studies."

Patient advocacy organisation Meningitis NOW, which ran a campaign to persuade the government to broaden MenB vaccination, described today's announcement as a major step forward in the fight to help protect people from the life-threatening disease.

The charity's chief executive, Dr Tom Nutt, said the move "will be welcomed by all those who have fought for better protection for precious young lives. It represents real progress and has significant potential to prevent cases of meningitis."

He added, however, that there is still more to be done to plug the vaccination gap, calling for eligibility to be expanded to include young people already at university and younger teenagers.

https://pharmaphorum.com/news/uk-offers-meningitis-jab-young-people-after-outbreak

State media releases reported details of Iran-US draft deal

 

New details of a reported 14-point draft understanding between Iran and the United States have been published by Mehr News, which cited a source close to the Iranian negotiating team.

According to the report, the draft includes the following provisions:

1. A permanent and immediate halt to fighting on all fronts, including Lebanon.

2. A US commitment not to interfere in Iran's internal affairs and to respect the sovereignty of the Islamic Republic of Iran.

3. The full lifting of the naval blockade within 30 days.

4. A US commitment to withdraw its forces from areas surrounding Iran.

5. The reopening of the Strait of Hormuz within 30 days under arrangements set by Iran.

6. The suspension of sanctions on Iran's oil sales, petrochemical products and derivatives, along with full Iranian access to the resulting financial resources.

7. A requirement for the United States and its allies to present plans for Iran's reconstruction worth at least $300 billion.

8. A 60-day negotiating period aimed at reaching a final agreement covering nuclear issues and the complete removal of US primary and secondary sanctions, as well as United Nations Security Council and International Atomic Energy Agency Board of Governors resolutions.

9. A reiteration of Iran's commitment under the Nuclear Non-Proliferation Treaty not to produce nuclear weapons.

10. During the negotiation period, the United States would not deploy additional forces to the region or impose new sanctions.

11. The release of $24 billion in blocked Iranian funds during the 60-day negotiation period, with half of that amount to be made available to Iran before negotiations begin.

12. The establishment of a monitoring mechanism to implement the agreement.

13. Approval of the final agreement through a United Nations Security Council resolution.

14. Final negotiations would not begin before the release of half of Iran's blocked funds, the suspension of Iran's oil sanctions and the lifting of the naval blockade. The final agreement would focus exclusively on the fate of enriched material and enrichment activities, sanctions relief and plans to rebuild Iran's economy. Discussions regarding Iran's missile program and support for resistance groups would be definitively excluded from the agenda.

Foreign Ministry spokesman Esmail Baghaei has said the text still requires review and finalization by the relevant authorities in Iran.

https://www.iranintl.com/en/liveblog/202606062776

Missile capabilities excluded from proposed nuclear talks framework - IRNA

 

Iran's state news agency IRNA reported that the current draft agreement with the United States is defined by seven broad principles and that Iran's missile capabilities would not be part of the agenda during proposed negotiations.

According to IRNA, only three issues would be addressed during the 60-day talks following the signing of the memorandum: the continuation of Iran's nuclear program, the lifting of US sanctions and a mechanism for compensation.

IRNA also reported that no agreement on the nuclear file has been reached within the current memorandum.

https://www.iranintl.com/en/liveblog/202606062776

Iran media denies reports of $3 billion transfer to Iran

 

Semi-oficial Mehr News Agency denied reports that $3 billion had been transferred from the United Arab Emirates to Iran, saying none of the Islamic Republic's frozen financial assets have been released.

The response came after reports alleged that Tehran's announcement of a ceasefire followed the delivery of a US message through a Qatari delegation on June 8 and coincided with the transfer of $3 billion from Abu Dhabi to Tehran aboard an Emirati Boeing 737 aircraft.

Mehr said that, to date, none of Iran's blocked funds had been unfrozen.

https://www.iranintl.com/en/liveblog/202606062776

US continues to enforce blockade against Iran, CENTCOM says

 

US Central Command said US Navy warships and air assets continue to patrol regional waters to enforce the blockade against Iran, adding that American forces have redirected 136 commercial vessels and disabled nine others.

"As of today, US forces have redirected 136 commercial vessels and disabled 9 to ensure compliance," CENTCOM said in a post on X accompanying images of the operations.

The latest figures indicate an expansion of US maritime enforcement measures targeting traffic linked to Iran.

https://www.iranintl.com/en/liveblog/202606062776