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Saturday, February 8, 2020

Gavin Newsom’s single-payer commission is doomed to fail

Last week, Gavin Newsom’s Healthy California for All Commission convened for the first time. The commission has been tasked with figuring out how to install a single-payer healthcare system statewide.
The commission’s 13 voting and five non-voting members represent a who’s-who of big-government academics, union leaders, and public health officials. If they approach their job with any measure of objectivity, they’ll find what other blue-state officials who have examined single-payer have found: there’s no way to make the numbers work.
No state — not even one as large and wealthy as California — can afford to pay for the care of every one of its residents, both legal and illegal. Bringing single-payer to the Golden State would cripple our economy and wallop taxpayers.
Newsom specifically requested that his commissioners design a “unified financing system” for a future government-run health plan. The commission will release its initial findings this July, with final recommendations to the legislature coming in February of next year.
The commission has an impossible task. The price tag for single-payer is simply too high.
Consider California’s last flirtation with a single, government-run healthcare system – Senate Bill 562, which passed the state Senate in 2017. The Democratic-controlled State Assembly never even scheduled a vote on the measure, which lacked any revenue-raising mechanisms despite calling for roughly $400 billion in annual spending — more than double the state budget that year.
As Assembly Speaker Anthony Rendon said, “This bill wasn’t even half-baked. It wasn’t even a bill. It was an incomplete list of principles.”
California’s overwhelmingly Democratic legislature was hardly the first group of progressives to balk at single-payer’s price tag.
Six years ago, Vermont — Bernie Sanders’s home state — got cold feet. Implementing single-payer in the Green Mountain State would have required a new 9.5-percent state income tax and a new 11.5-percent payroll tax on employers.
Vermont’s then-governor, Peter Shumlin, abandoned the plan after deciding that the “potential economic disruption and risks would be too great to small business, working families, and the state’s economy.” He called it “the greatest disappointment of my political life.”
In 2016, voters in Colorado rejected Amendment 69, a ballot measure that would have created a statewide single-payer system, by a 79-21 margin. Even the state’s Democratic governor, John Hickenlooper, urged his fellow citizens to reject the initiative. Here, too, cost was the main sticking point. The plan would have imposed a new 10 percent payroll tax on state residents and roughly doubled the state budget.
Not only is single-payer costly — it results in poor-quality care.
Consider Canada’s government-run system, which outlaws private coverage for anything deemed medically necessary, just as Sanders’s brand of Medicare for All would. The median wait for Canadians seeking specialist treatment following referral from a general practitioner exceeded 20 weeks last year. That’s up from just 9.3 weeks in 1993.
Patients in the United Kingdom’s government-run National Health Service have it just as bad. In December, wait times at emergency rooms throughout Britain were the longest on record, with one in five patients waiting more than four hours to be seen. Over 2,000 patients that month waited more than 12 hours for a hospital bed.
The waits imposed by government-run health systems often have tragic and irreversible consequences. A new report from a British watchdog group estimates that 22 people a month endure severe or permanent sight loss because of long wait times for eye doctors.
One-quarter of British cancer patients experience avoidable delays in diagnosis, according to Cancer Research UK, a charity. Long waits for tests were responsible for one-fourth of those avoidable delays. It’s no wonder survival rates for cancers of the breast, colon, lung, and prostate are lower in the United Kingdom than in the United States.
Yet Gov. Newsom and his allies remain intent on bringing socialized medicine to the Golden State. If his handpicked commissioners conduct a sober review of the facts, they’ll recommend that the governor stop his single-payer crusade.
Sally C. Pipes is president, CEO, and the Thomas W. Smith fellow in healthcare policy at the Pacific Research Institute. Her latest book is False Premise, False Promise: The Disastrous Reality of Medicare for All, (Encounter 2020).
Gavin Newsom’s single-payer commission is doomed to fail

Canada Scientist In Midst Of Chinese Bio-Espionage Probe Found Dead In Africa?

Update (1135ET): It seems that Mr. Plummer made a habit of getting the biological material he was working on “stolen,” as we found a report from 2009 in the Winnepeg Free Press that details the theft of 22 vials of biological material was “confirmed by scientific director Dr. Frank Plummer.”
Plummer, allegedly, alerted authorities to the missing material on the same day a former vaccine researcher was arrested by FBI special agents after U.S. Customs discovered the vials stuffed in a glove in the trunk of his car at the Manitoba-North Dakota border crossing.
Some of the vials included genes from the deadly Ebola virus, but local scientists say the material is not infectious.
But more than a week after the theft came to light, police said no one from the lab has reported the incident.
Plummer has said the researcher signed a form declaring he did not steal anything from the lab and understood he was not allowed to. The national lab does not conduct searches of staff when they exit the lab and does not routinely take inventory of the thousands of vials containing non-infectious biological substances.
However, court documents allege the former researcher stole the vials on his last day of work at the virology lab in January because “he did not want to start his research over from the beginning when he entered into his next fellowship” with the National Institutes of Health at the Biodefense Research Laboratory in Maryland.
All very curious.
*  *  *
As GreatGameIndia.com detailed earlier, in a very strange turn of events, renowned scientist Frank Plummer who received Saudi SARS Coronavirus sample and was working on Coronavirus (HIV) vaccine in the Winnipeg based Canadian lab from where the virus was smuggled by Chinese Biowarfare agents and weaponized as revealed in GreatGameIndia investigation, has died in mysterious conditions.

Frank Plummer was the key to the Chinese Biological Espionage case at Winnipeg’s National Microbiology Laboratory.
According to CBC, Plummer, 67, was in Kenya, where he was a keynote speaker at the annual meeting of the University of Nairobi’s collaborative centre for research and training in HIV/AIDS/STIs.
Dr. Larry Gelmon, who helped set up that meeting, said Plummer collapsed and was taken to hospital in Nairobi, where he was pronounced dead on arrival.
No confirmed cause of death has yet been released.
Plummer was born and raised in Winnipeg, where he headed up Canada’s National Microbiology Laboratory for several years.
He was also involved in an innovative research partnership between the University of Manitoba and the University of Nairobi, established before the world was very aware of HIV/AIDS.
“He helped to identify a lot of the key factors that are involved in HIV transmission in the early days,” said Keith Fowke, a professor in the medical microbiology and infectious diseases department at the University of Manitoba.
“He was so hopeful that he was on the path that would end with discovery of the HIV vaccine — the road he had started down almost 30 years ago,” said Plummer’s colleague, Dr. Allan Ronald.
What is not mentioned in the CBC report however is that Plummer worked in the same National Microbiology Laboratory (NML) in Winnipeg, Canada from where Chinese Biowarfare agent Xiangguo Qiu and her colleagues smuggled SARS Coronavirus to China’s Wuhan Institute of Virology where it is believed to have been weaponized and leaked.
GreatGameIndia @GreatGameIndia
EXCLUSIVE Bioweapon Thread
How China Stole Coronavirus From Canada And Weaponized Ithttps://greatgameindia.com/coronavirus-bioweapon/ 

Coronavirus Bioweapon – How China Stole Coronavirus From Canada And Weaponized It | GreatGameIndia

Coronavirus Bioweapon : How Chinese agents stole Coronavirus from Canada’s National Microbiology Laboratory and weaponized it into a Bioweapon.
greatgameindia.com

Infact, as GreatGameIndia reported in our exclusive report on Coronavirus Bioweapon, as Scientific Director Frank Plummer was the one who acquired the SARS Coronavirus sample of the Saudi patient at the NML Winnipeg Lab from Ron Fouchier, a leading virologist at the Erasmus Medical Center (EMC) in Rotterdam, the Netherlands who was sent the virus by Egyptian virologist Dr. Ali Mohamed Zaki who isolated and identified a previously unknown type of Coronavirus from the Saudi patient’s lungs.
Fouchier sequenced the virus from a sample sent by Zaki using a broad-spectrum “pan-coronavirus” real-time polymerase chain reaction (RT-PCR) method to test for distinguishing features of a number of known coronaviruses known to infect humans.
This Coronavirus sample arrived at Canada’s NML Winnipeg facility on May 4, 2013 from the Dutch lab received by Frank Plummer. The Canadian lab grew up stocks of the virus and used it to assess diagnostic tests being used in Canada. Winnipeg scientists worked to see which animal species can be infected with the new virus.
Research was done in conjunction with the Canadian Food Inspection Agency’s national lab, the National Centre for Foreign Animal Diseases which is housed in the same complex as the National Microbiology Laboratory.
This Winnipeg based Canadian lab was targeted by Chinese agents in what could be termed as Biological Espionage. The viruses was reportedly stolen from the Canadian lab by Chinese Biowarfare agent Xiangguo Qiu and her colleagues and smuggled to none other than the Wuhan Institute of Virology where the virus is believed to be weaponized and leaked.
Further, Frank Plummer was also working on HIV vaccine and interesting recently published study be Indian scientists found HIV-like injections in Wuhan Coronavirus – the key that made the jump to people possible. The Indian Scientists came under massive online criticism by Social Media experts and were  forced to withdraw their study, in retaliation of which now the Indian authorities have opened an investigation against China’s Wuhan Institute of Virology. Although it should be noted that now China has started using HIV vaccine to cure Coronavirus.
Frank Plummer was the key to the entire investigation on the origins of Coronavirus Bioweapon. But will the Canadian government open an investigation into this matter? Unlike their American counterparts who have charged the Chinese Biowarfare agents trying to smuggle deadly viruses from Harvard University, the deatils of the Canadian investigation on the Winnipeg Biological Espionage case is shrouded in secrecy.
http://feedproxy.google.com/~r/zerohedge/feed/~3/DxUwH-4vdk8/canadian-scientist-center-chinese-bio-espionage-probe-found-dead-africa

Adverum: Interim Gene Therapy Data in Macular Degeneration Phase 1 Trial

— Robust efficacy with evidence of a dose response —
— 6/6 patients rescue-injection-free in cohort 1, with 3 patients at 52 weeks —
— 4/6 patients rescue-injection-free in cohort 2 (lower dose) at 24 weeks —
— Company to host and webcast a discussion with key opinion leaders Sunday, February 9, at 10:00 am EST —
 Adverum Biotechnologies, Inc. (Nasdaq: ADVM), a clinical-stage gene therapy company targeting unmet medical needs in ocular and rare diseases, today announced new interim clinical data from the OPTIC Phase 1 dose-ranging clinical trial of ADVM-022 intravitreal injection gene therapy. OPTIC includes treatment-experienced patients with wet age-related macular degeneration (AMD). The data are being presented today by David S. Boyer, M.D., senior partner, Retina-Vitreous Associates Medical Group and adjunct clinical professor of ophthalmology with the University of Southern California/Keck School of Medicine in Los Angeles, at the Angiogenesis, Exudation, and Degeneration 2020 Annual Meeting in Miami.
A copy of the presentation is available on the Adverum corporate website under Events and Presentations in the Investors section.
https://www.marketscreener.com/ADVERUM-BIOTECHNOLOGIES-27535811/news/Adverum-Biotechnologies-Reports-New-Interim-Data-from-Cohorts-1-and-2-of-OPTIC-Phase-1-Trial-of-ADVM-29967519/

1st U.S. attempt at CRISPR gene editing in cancer appears safe

The first test in the United States of the CRISPR gene-editing tool in cancer appears to be safe, but it’s too soon to know whether it’s effective, U.S. researchers reported on Thursday in the journal Science.
“The findings represent an important advance in the therapeutic application of gene editing and highlight the potential to accelerate development of cell-based therapies,” Jennifer Doudna of the University of California at Berkeley, who pioneered the gene editing technique, and her colleague Jennifer Hamilton write in an editorial.
The CRISPR approach has quickly become the preferred method of gene editing in research labs because of its ease of use compared with older techniques, and doctors have begun testing it to treat a number of diseases.
CRISPR-Cas9, used in this study, works like a pair of molecular scissors that can target and trim away parts of the genome and replace them with new stretches of DNA.
CRISPR has already shown promise at editing the genes of patients with beta thalassemia and sickle cell disease in clinical trials.
In the latest study, Dr. Edward Stadtmauer of the University of Pennsylvania in Philadelphia and colleagues tested it in three patients with advanced cancers. Two had the blood cancer multiple myeloma and one had sarcoma, a cancer that attacks connective tissues.
The researchers paired the use of CRISPR with a type of immunotherapy in which scientists harvest T-cells from a patient’s immune system, reprogram them to attack cancer cells and infuse them back into patients.
Engineered T cell therapies, such as CAR-T therapy (or chimeric antigen receptor T cell therapy), can produce long-lasting remission in patients with blood cancers. But the treatments don’t work for many other kinds of cancer, the immunity can wane and they can cause serious side effects.
Stadtmauer and colleagues sought to use CRISPR to address some of those issues. They took immune system cells from the patients’ blood and used the CRISPR-Cas9 system to delete genes from the cells that might hamper the immune system’s ability to fight cancer, and engineered the cells to recognize and attack cancer cells.
The team then infused these cells back into the patients and watched to see if they would multiply. So far, the researchers have not seen any toxic side effects. The engineered T-cells started growing in all of the patients and lasted for up to nine months after the infusion.
“Until now, it has been unknown whether CRISPR-Cas9 edited T cells would be tolerated and thrive once reinfused into a human,” Doudna writes. “The big question that remains unanswered by this study is whether CRISPR-edited, engineered T cells are effective against advanced cancer.”
The pilot study was designed to track safety. Larger trials will be needed to test for efficacy. At the end of the trial, one patient died from advanced cancer, and the other two were receiving other treatments.
A key concern with CRISPR-edited cells is that the technique has been shown to create some “off-target” or unintended edits in the genome.
Study co-author Dr. Carl June, an immunologist at the University of Pennsylvania who pioneered CAR-T cell therapy, said the team found two off-target effects.
One was a rare change in the DNA code that occurred in 1 in 1,000 of the edited cells. The other was a chromosome translocation, in which a chromosome reattached itself to the wrong chromosome. This occurred in fewer than 1.5 percent of the infused cells, June said in an email to Reuters Health.
The infused cells with these unintended edits did not survive as well as the correctly edited genes, he said.
Based on the promising safety profile, June said it’s likely that many academic centers and companies will try the technique in further clinical trials.
“We hope to work with companies to advance this but at this point, there are no firm plans,” he said.
SOURCE: bit.ly/3bjFKU3, bit.ly/2v9MALe and bit.ly/3bhdCkj Science, online February 6, 2020.
https://www.reuters.com/article/us-health-cancer-gene-editing/first-u-s-attempt-at-crispr-gene-editing-in-cancer-appears-safe-idUSKBN200309

Coronavirus brings China’s surveillance state out of the shadows

When the man from Hangzhou returned home from a business trip, the local police got in touch. They had tracked his car by his license plate in nearby Wenzhou, which has had a spate of coronavirus cases despite being far from the epicenter of the outbreak. Stay indoors for two weeks, they requested.
After around 12 days, he was bored and went out early. This time, not only did the police contact him, so did his boss. He had been spotted near Hangzhou’s West Lake by a camera with facial recognition technology, and the authorities had alerted his company as a warning.
“I was a bit shocked by the ability and efficiency of the mass surveillance network. They can basically trace our movements with the AI technology and big data at any time and any place,” said the man, who asked not to be identified for fear of repercussions.
Chinese have long been aware that they are tracked by the world’s most sophisticated system of electronic surveillance. The coronavirus emergency has brought some of that technology out of the shadows, providing the authorities with a justification for sweeping methods of high tech social control.
Artificial intelligence and security camera companies boast that their systems can scan the streets for people with even low-grade fevers, recognize their faces even if they are wearing masks and report them to the authorities.
If a coronavirus patient boards a train, the railway’s “real name” system can provide a list of people sitting nearby.
Mobile phone apps can tell users if they have been on a flight or a train with a known coronavirus carrier, and maps can show them locations of buildings where infected patients live.
Although there has been some anonymous grumbling on social media, for now Chinese citizens seem to be accepting the extra intrusion, or even embracing it, as a means to combat the health emergency.
“In the circumstances, individuals are likely to consider this to be reasonable even if they are not specifically informed about it,” said Carolyn Bigg, partner at law firm DLA Piper in Hong Kong.

NEW TECHNOLOGIES

Telecoms companies have long quietly tracked the movements of their users. China Mobile promoted this as a service this week, sending text messages to Beijing residents telling them they can check where they have been over the past 30 days. It did not explain why users might need this, but it could be useful if they are questioned by the authorities or their employers about their travel.
“In the era of big data and internet, the flow of each person can be clearly seen. So we are different from the SARS time now,” epidemiologist Li Lanjuan said in an interview with China’s state broadcaster CCTV last week, comparing the outbreak to a virus that killed 800 people in 2003.
“With such new technologies, we should make full use of them to find the source of infection and contain the source of infection.”
The industry ministry sent a notice to China’s AI companies and research institutes this week calling on them to help fight the outbreak. Companies have responded with a flurry of announcements touting the capabilities of their technology.
Facial recognition firm Megvii said on Tuesday it had developed a new way to spot and identify people with fevers, with support from the industry and science ministries. Its new “AI temperature measurement system”, which detects temperature with thermal cameras and uses body and facial data to identify individuals, is already being tested in a Beijing district.
SenseTime, another leading AI firm, said it has built a similar system to be used at building entrances, which can identify people wearing masks, overcoming a weakness of earlier technology. Surveillance camera firm Zhejiang Dahua says it can detect fevers with infrared cameras to an accuracy within 0.3ÂșC.
In an interview with state news agency Xinhua, Zhu Jiansheng of the China Academy of Railway Sciences explained how technology can help the authorities find people who might be exposed to a confirmed or suspected coronavirus case on a train.
“We will retrieve relevant information about the passenger, including the train number, carriage number and information on passengers who were close to the person, such as people sitting three rows of seats before and after the person,” he said.
“We will extract the information and then provide it to relevant epidemic prevention departments.”
https://www.reuters.com/article/us-china-health-surveillance/coronavirus-brings-chinas-surveillance-state-out-of-the-shadows-idUSKBN2011HO

China calls for work to resume on road, waterway projects by February 20

China Ministry of Transport said on Saturday that road and waterway projects in the country, except those in coronavirus stricken province of Hubei and other severely affected areas, should aim to resume construction by Feb. 20.
Key projects should start as soon as possible, the ministry added in a statement on its website.
https://www.reuters.com/article/us-china-health-transport-road/china-calls-for-work-to-resume-on-road-waterway-projects-by-february-20-idUSKBN2020BI

Singapore lifts virus alert to SARS level, sparking panic buying

Singapore on Friday raised its coronavirus alert level and reported more cases not linked to previous infections or travel to China, a move that sparked panic-buying of essentials in some shops across the island.
As Singapore’s infected tally hit 33, the alert level was raised to orange – a level reached during the 2003 Severe Acute Respiratory Syndrome outbreak and the 2009 H1N1 influenza which indicates the virus is severe and passes easily between persons.
With the disease reviving memories of SARS which killed more than 30 people in Singapore and hundreds worldwide, shoppers started clearing shelves of toilet paper, noodles and rice, and formed long queues in supermarkets across the island on Friday evening, videos posted on social media showed.
“I understand that people are concerned after the announcement this afternoon. However, we must…not hoard items unnecessarily. This will create undue panic and is unhelpful to the situation at hand,” trade minister Chan Chun Sing said in a Facebook post about the panic buying.
Singapore’s highest alert level is red, which indicates the virus is spreading widely and can result in major disruption such as closing schools.
“As there are now a few local cases without any links to previous cases or travel history to China, we have stepped up our risk assessment,” the health ministry said announcing the new orange alert level on Friday.

It also said firms should be prepared for “widespread community transmission” and advised that non-essential large-scale events should be deferred or cancelled.
The Singapore Airshow will go ahead next week although organisers may limit public visitors, it added.
Of the new cases reported on Friday, one was a teacher and authorities said all students and staff who had come into contact with her would have to spend two weeks at home.
A British man has also contracted the coronavirus after travelling to a business meeting in Singapore which has also been linked to cases in the city-state, Malaysia and South Korea, health ministry official Kenneth Mak said. [nL4N2A61BT]
Mak said authorities had not yet identified the source of infection at the meeting of more than 100 employees from an as-yet-unnamed firm at the Grand Hyatt Hotel in mid-January.
With evidence of local transmissions in Singapore mounting, people appeared to be taking no chances.
“People are not sure what the raised virus alert means and are stocking up food items and other essentials. There is somewhat of a mass hysteria,” said a 45-year-old tech executive who said he spent over an hour lining up at outside his neighborhood grocery store.
https://www.reuters.com/article/us-china-health-singapore/singapore-lifts-virus-alert-to-sars-level-sparking-panic-buying-idUSKBN20111X