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Thursday, April 9, 2020

Pfizer identifies lead COVID-19 candidate

The WSJ reports that Pfizer (NYSE:PFE) has found a promising coronavirus treatment that works by blocking viral replication. It plans to start testing this summer.
Rheumatoid arthritis med Xeljanz (tofacitinib), a Janus kinase inhibitor, is another option. Testing in COVID-19 patients will start this week in Italy.
Also, it intends to publish research on whether one of its antibiotics benefits COVID-19 patients.
Clinical trials should launch this month evaluating a vaccine candidate that it is developing with Germany’s BioNTech SE (NASDAQ:BNTX).
https://seekingalpha.com/news/3559589-pfizer-identifies-lead-covidminus-19-candidate

Tiziana Life Sciences up 91% on inhalable treatment of COVID-19

Thinly traded nano cap Tiziana Life Sciences plc (NASDAQ:TLSA) rockets 91% premarket on average volume in reaction to its announcement that it has developed an investigational new technology that enables the direct delivery of IL-6-inhibiting monoclonal antibodies into the lungs via a handheld inhaler or nebulizer.
The company says the technology advances its IL-6 candidate TZLS-501 for the potential treatment of COVID-19, adding that it could be useful with other antibodies and drugs. A provisional patent application has been filed.
It acquired the candidate from Swiss biotech Novimmune in 2017.
IL-6 is a proinflammatory cytokine (protein) that is believed to play a key role in the development of severe lung damage in severely ill COVID-19 patients with acute respiratory distress syndrome.
https://seekingalpha.com/news/3559578-tiziana-life-sciences-up-91-on-inhalable-treatment-of-covidminus-19

Stocks look for another winning session

Global stocks continue to gain on hopes that the pandemic is nearing a peak and that a crude oil output deal will be struck.
In Asia, the Shanghai Composite Index rose 0.4%, Hong Kong’s Hang Seng Index was up 1.3%, South Korea’s Kospi gained 1.6% and Australia’s ASX rallied 3.5%. Japan’s Nikkei ended flat on the day after a dour appraisal from Bank of Japan Governor Haruhiko Kuroda on the economy.
Meanwhile, European stocks are breaking higher, led by Germany’s DAX up 2.1% and U.K.’s FTSE 100 1.9% higher.
U.S. stock futures are all pointing to modest gains at the moment.
https://seekingalpha.com/news/3559556-stocks-look-for-another-winning-session

Wednesday, April 8, 2020

51 recovered coronavirus patients test positive again in South Korea

At least 51 patients diagnosed as having fully recovered from the coronavirus in South Korea have tested positive a second time after leaving quarantine, according to officials.
The patients from Daegu all tested positive in a “relatively short time” after they were given the all-clear from their initial infections, the Korea Centers for Disease Control and Prevention (KCDC) said, according to the government-funded Yonhap News Agency.
A specialist team has been sent to conduct an epidemiological investigation in the city, which is the epicenter of the epidemic in South Korea, the agency says.
For now, the KCDC’s director-general, Jeong Eun-kyeong, believes it is likely the infection was re-activated after remaining dormant in the patients, as opposed to them being reinfected, the report said.
Either way, it strengthens fears that the contagion remains a hidden danger even after it appears to have gone — with whistleblowing Chinese doctors previously warning it is even deadlier the second time.
Doctors on the front lines in Wuhan — where the virus first originated — previously said as many as 10% of those assumed to have recovered had tested positive again. At least one patient — Li Liang, 36 — reportedly died from the disease after previously getting the all-clear.
Paul Hunter, an infectious diseases professor at the University of East Anglia, told MailOnline that the cases were far more likely to be “reactivations” — or even just a sign of current testing being flawed.
“Personally, I think the most likely explanation is that the clearance samples were false negative,” Hunter told the site.
https://nypost.com/2020/04/07/51-recovered-coronavirus-patients-test-positive-again-in-south-korea/

Dow Jumps Nearly 800 Points After Sanders Drops Out


The stock market rallied on Wednesday after Senator Bernie Sanders (D-Vt.) dropped out of the presidential race—removing a key source of political unpredictability for Wall Street amid the ongoing economic uncertainty caused by the coronavirus pandemic.
  • The Dow Jones industrial average was up 3.4%, almost 800 points, on Wednesday, while the S&P 500 rose 3.4% and the Nasdaq Composite gained 2.6%.
  • Giving stocks an extra boost was Sanders’ announcement that he would be dropping out of the 2020 presidential race, since some of his progressive policy proposals, including Medicare-for-All, had sparked concern among business leaders on Wall Street.
  • The market rally gained steam throughout the day, as investors also continue to focus on progress being made to contain the coronavirus pandemic and when the economy can eventually get back on track.
  • Wall Street has cheered news that the number of new COVID-19 cases, both in the U.S. and globally, has started to slow since last Friday, according to data from Johns Hopkins University.
  • Dr. Anthony Fauci, the White House’s top expert on infectious diseases, told Fox News on Wednesday that the number of deaths in the U.S. is lower than originally projected, saying that there should be a turnaround after this week.
Crucial statistic: The S&P 500 is now up more than 20% from its coronavirus sell-off low point in late March. Markets have steadily rebounded in recent weeks, taking solace in fiscal stimulus packages from the federal government and more recently, signs that coronavirus containment efforts are paying off.
Crucial quote: “The difference between now and the start of the pandemic is that we can at least see the end,” says Brad McMillan, chief investment officer for Commonwealth Financial Network. Stocks have subsequently gotten a boost, as investors are increasingly focusing on when the economy can recover: “We can see that we have flattened the curve.”
Big number: 25% of Americans have either lost their job or seen their wages slashed as a result of the coronavirus shutdown, according to CNBC’s All-America Economic Survey. The survey, which gauges the public’s view of the U.S. economy, posted the biggest and fastest decline in sentiment ever. On the flip side, however, some 51% of respondents said the economy will improve in 2021.
Key background: Stocks closed slightly negative on Tuesday, after a volatile session in which the major indexes pared back almost 4% of earlier gains. That followed a massive market rally on Monday, in which the Dow posted its third-biggest point gain ever. The Dow gained 7.8%, more than 1,600 points on Monday, while the S&P 500 jumped 7.2% and the Nasdaq rose 7.3%.
https://www.forbes.com/sites/sergeiklebnikov/2020/04/08/dow-jumps-nearly-800-points-after-sanders-drops-out-of-presidential-race/#68a892c34fc1

U.S. to seize exports of masks and gloves amid coronavirus crisis

The United States will seize exports of key protective medical gear until it determines whether the equipment should be kept in the country to combat the spread of the new coronavirus, two federal agencies announced on Wednesday.
U.S. Customs and Border Protection (CBP) will hold exports of respirators, surgical masks and surgical gloves, according to a joint announcement made with the Federal Emergency Management Agency. FEMA will then determine if the equipment should be returned for use in the United States, purchased by the U.S. government or exported.
President Donald Trump issued a memorandum on Friday that directed federal agencies to use any authority necessary to keep the highly sought-after medical supplies in the United States.
Governors, mayors and physicians have voiced alarm for weeks over crippling scarcities of personal protective gear for first-responders and front-line healthcare workers, as well as ventilators and other medical supplies.
The move to seize exports will include N95 respirator masks, which filter airborne particles and are used to protect against COVID-19, the potentially lethal respiratory disease caused by the new coronavirus.
The U.S. manufacturing company 3M Co, a leading producer of the masks worldwide, said on Monday that it had reached a deal with the Trump administration that would allow it to continue to export the masks to Canada and Latin America despite the new restrictions. The company had said days earlier that ceasing exports to those regions would have “humanitarian implications.”
A federal regulation that outlines FEMA’s procedures for seizing and vetting the exports will go into effect on Friday and remain in place until Aug. 10, according to a draft version posted online.
FEMA will aim to make decisions about exports quickly and seek to minimize disruptions to the supply chain, the draft regulation said.

Some state and local government officials have accused FEMA in recent days of confiscating shipments of masks and other supplies coming from overseas.
An official with the U.S. Department of Homeland Security who requested anonymity to discuss the matter earlier this week said half of the protective gear brought to the United States on U.S. government flights can be redirected to high-need areas around the country, but disputed the idea that the equipment had been seized.
https://www.reuters.com/article/us-health-coronavirus-usa-supplies/u-s-to-seize-exports-of-masks-and-gloves-amid-coronavirus-crisis-idUSKCN21Q30Q

NY hospital sends ‘borderline’ Covid-19 patients home with oxygen monitors

Some coronavirus patients who would have been admitted into the emergency department at a New York hospital are being sent home with an oxygen-monitoring device as the city’s medical system struggles to reserve resources for only the sickest people.
The new program at NewYork-Presbyterian Hospital is an example of how doctors are adapting and loosening normal protocols to ease the strain on emergency rooms and intensive care units in New York state, the epicenter of the coronavirus pandemic in the United States.
Since last week, more than 200 people with confirmed or suspected COVID-19, the respiratory illness caused by the virus, have been sent home with a pulse oximeter to track their oxygen levels. A doctor or nurse practitioner follows up with them via video conference.
“Some of these patients might have been on the borderline of admission,” Dr. Rahul Sharma, who is overseeing the program as the chief of emergency medicine at Presbyterian’s Weill Cornell Medical Center, said in an interview.
An oximeter is a small electronic device that clips onto a fingertip to indirectly measure the oxygen saturation of a patient’s blood. In severe COVID-19 cases, the virus can block up the lungs, hindering their ability to pass oxygen from the air into the bloodstream. While most who contract the virus recover, it has killed at least 4,900 people in the city, according to a Reuters tally.

Some of the NewYork-Presbyterian patients are also being sent home with a 30lb (14 kg) portable oxygen concentrating machine which sends oxygen-rich air through a nasal cannula, a two-pronged tube inserted into the nostrils.
The patient is asked to log their oximeter readings to share with a doctor or nurse practitioner at 12-hour and 24-hour consultations. The patient may be re-admitted to the hospital if they take a turn for the worse.
No patient in the program is known to have died at home as of Wednesday, but about 15 percent were asked to return to hospital to be admitted for inpatient care, a hospital spokeswoman said.
At least two other hospital systems outside of New York unveiled similar new programs using oximeters in late March. Doctors at other hospitals said Presbyterian’s approach could have benefits for patients with a disease about which they still have much to learn.

“There’s no guarantees in either direction, there are risks to hospitalization and there are risks with sending people home,” Dr. Laura Burke, an assistant professor of emergency medicine at Harvard Medical School, said in an interview.
Doctors have noticed there can be a worrisome lag in symptoms among some COVID-19 patients, with oxygen saturation dropping for some time before a patient is aware of breathing problems.
For patients that turn up at an emergency department with other COVID-19 symptoms, giving a pulse oximeter to use at home could be one way to “err on the side of safety,” Burke said.
https://www.reuters.com/article/us-health-coronavirus-usa-home/new-york-hospital-sends-some-borderline-covid-19-patients-home-with-oxygen-monitors-idUSKCN21Q3F0