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Monday, April 13, 2020

Can-Fite up 46% premarket on study of lead drug in COVID-19

The Institutional Review Board at Rabin Medical Center in Petah Tikva, Israel, has signed off on a pilot study evaluating Can-Fite BioPharma’s (NYSEMKT:CANF) lead candidate Piclidenoson in moderately-to-severely ill COVID-19 patients.
The randomized, open-label, two-arm trial will assess Piclidenoson plus standard support care compared to standard support care alone in 40 hospitalized patients who will be treated for up to four weeks.
Efficacy measures include time to resolution of viral shedding, time to resolution of clinical symptoms, measures of respiratory function, need for ventilatory support, and overall mortality.
Piclidenoson is an oral anti-inflammatory small molecule. Its mechanism of action is mediating A3 adenosine receptors, key signalling proteins which play key roles in the production of inflammatory cytokines. It says it has shown antiviral effects against single-stranded RNA viruses like SARS-CoV-2.
Shares up 46% premarket on average volume.
https://seekingalpha.com/news/3560022-can-fite-up-46-premarket-on-study-of-lead-drug-in-covidminus-19

Athersys on go with pivotal study of MultiStem in COVID-19

Athersys (NASDAQ:ATHX) is up 26% premarket on light volume in reaction to its announcement that the FDA has signed off on a pivotal Phase 2/3 clinical trial, MACOVIA, evaluating MultiStem therapy in COVID-19 patients with moderate-to-severe acute respiratory distress syndrome, a Fast Track-tagged indication.
The primary endpoint of the open-label study will be the number of ventilator-free days compared to placebo. Secondary endpoints will include pulmonary function, all-cause mortality, tolerability and quality of life measures. The study will launch this quarter.
https://seekingalpha.com/news/3560018-athersys-on-go-pivotal-study-of-multistem-in-covidminus-19-shares-up-26-premarket

Alnylam up 4% premarket on $2B Blackstone investment

Deploying some of its $150B cash hoard, Blackstone Group (NYSE:BX) will invest $2B in Alnylam Pharmaceuticals (NASDAQ:ALNY) aimed at boosting its pace of bringing products to market.
The deal includes a $1B stake led by Blackstone Life Sciences for 10% of future inclisiran royalties and up to $150M to help fund development of two other ALNY candidates.
Blackstone credit arm GSO Capital Partners will provide ALNY with a loan of up to $750M, while Blackstone will acquire $100M of newly issued common stock.
ALNY is up 4% premarket on light volume, while BX is down 1%
https://seekingalpha.com/news/3560031-alnylam-up-4-premarket-on-2b-blackstone-investment

Sunday, April 12, 2020

States say rapid coronavirus testing machines sitting idle

Some state governors are fuming that rapid coronavirus testing machines they were given are sitting idle because they weren’t given enough supplies to use them, according to a report.
The Abbot Laboratories machines were part of a bulk purchase by the federal governments and promised to complete tests in 15 minutes, the Wall Street Journal reported.
The kits were delivered to the states by the feds — but only with enough cartridges to test about 100 patients.
“It’s incredibly frustrating,” New Hampshire Gov. Chris Sununu said, the Journal reported. “There was a lot of hype on this nationally. To have 13 of these devices and no way to use them — I’m banging my head against the wall.”
Federal officials delivered 15 of the testing machines to all of the states except Alaska — regardless of the population — to help alleviate the shortage of testing equipment as the coronavirus pandemic continues to spread across the country.
But with only 120 cartridges included with the deliveries, the machines are generally sitting idle while state health officials figure out how to make use of them, the paper reports.
In Illinois, Gov. JB Pritzker said he thought he had a deal with Abbott, which is headquartered in his state, for testing about 3,000 tests per day and 88,000 per month. Instead, the state received 15 testing machines and 120 cartridges.
“That’s eight tests per machine for all of Illinois,” Pritzker said.
A spokesperson for Health and Human Services told the Journal that the feds had purchased limited quantities of the machines for state labs because officials waned to allow local hospitals to buy the devices as well.
Mia Heck, the spokesperson, said the states could order additional supplies through the US Centers for Disease Control and Prevention.
https://nypost.com/2020/04/12/states-say-rapid-coronavirus-testing-machines-sitting-idle/

New Yorkers refusing to be hospitalized over fear of getting coronavirus

FDNY statistics show that the number of New Yorkers who refuse to be taken to hospitals has more than doubled amid the coronavirus crisis — with EMTs blaming the situation on fear of contracting the deadly disease, The Post has learned.
Year-to-date data show an overall 73 percent increase in 911 calls that resulted in “refusals of medical aid,” with 37,968 cases compared to 21,982 during the same period in 2019.
But during March — when COVID-19 began spreading across the city with a vengeance — RMAs jumped by 118 percent, from 6,777 in 2019 to 14,706 this year.
And during early April, the number skyrocketed from 2,578 to 8,630 — an astonishing 235 percent surge.
One FDNY paramedic said some 911 calls about potentially life-threatening symptoms — such as chest pain — were resulting in patients willing to risk death rather than go to a hospital.
“There are numerous patients refusing because of COVID-19. People have underlying conditions and are refusing transport,” EMT Luis Lopez told The Post.
“Once we evaluate, they often say they are not going to the hospital because of the virus.”
He added: “We always want them to go because if you are calling 911 you obviously felt it was an emergency. But because of conditions [at the hospitals], people are refusing.”
Another FDNY paramedic — Megan Pfeiffer, who works in hard-hit Queens — said she’d encountered similar situations due to the pandemic.
“I had a few that were non-COVID that were hesitant to go to the hospital but we had to take them,” Pfeiffer told The Post.
“Those almost are harder than the COVID patients.”
Pfeiffer was recently featured in a front-page Post report that detailed how the city’s paramedics were essentially performing “battlefield triage” and “pretty much bringing patients to the hospital to die.”
A neurosurgeon at Manhattan’s Mount Sinai Hospital has also tweeted a series of warnings that people with symptoms of a stroke — including the deadliest type, known as emergent large vessel occlusion or ELVO — shouldn’t avoid hospitals.
“People are afraid…past few days we’ve had 3 #stroke patients delay calling EMS for hours because they were afraid to be brought to a hospital,” Dr. J Mocco wrote on Friday.
Mocco also tweeted that the number of ELVO cases handled by Mount Sinai’s Cerebrovascular Center has nearly doubled — and that he believed strokes were on the rise because COVID-19 “has a pro-inflammatory component.”
“Right now, people keep hearing they should avoid hospitals for non-emergencies, however, strokes are life-threatening,” Mocco told The Post in a direct message over Twitter on Sunday.
“We have to balance the message. Those suffering #BEFAST stroke symptoms are ALWAYS, even during this COVID pandemic, urged to get to the closest ER or call 911.”
FDNY spokesman Frank Dwyer noted that “overall call volume has been up dramatically” this year, with 202,000 year-to-date compared to 167,000 during the same period in 2019.
“So, there could be some correlation there — more overall calls would also lead to more RMAs overall,” he said.
https://nypost.com/2020/04/12/coronavirus-fears-have-new-yorkers-avoiding-hospitals-in-nyc/

Boeing to resume some Washington operations as soon as Monday

Boeing (NYSE:BA) plans to call about 2500 employees to resume operations at Puget Sound area and Moses Lake, Washington for its P-8 maritime surveillance aircraft, KC-46 aerial refueling tanker and support of 737 Max storage.
Other essential labs and support teams will also resume to support critical customer needs.
The company to implement wellness checks, staggering shift start times, require face masks to protect workers.
“Boeing’s work supporting the Department of Defense as a part of the defence industrial base is a matter of national security and has been deemed critical,” Boeing says. “Additionally, our commercial work supports critical global transportation.”
Shares +2.4%.
https://seekingalpha.com/news/3559954-boeing-to-resume-washington-operations-soon-monday

States Prepare Test-and-Trace Programs to Reopen Their Economies

Several states have launched new efforts to contain Covid-19, laying plans to test aggressively and track the potentially infected with help from nonprofits, universities and the private sector.
Massachusetts, Utah and North Dakota are among those working on the kinds of comprehensive strategies that public-health experts agree are needed to arrest the coronavirus’s spread and lift the social-distancing measures that have shuttered much of the U.S. economy.
“Even if the curve does flatten, we won’t be able to go back to work and school and regular life unless we chase the virus down much more significantly,” said Joia Mukherjee, chief medical officer of Partners in Health, a nonprofit working with Massachusetts to expand the state’s capacity to trace contacts of Covid-19 patients.
The question is how quickly the efforts that have begun can advance with beleaguered diagnostic testing programs across the U.S. still facing shortages of swabs, chemicals and other supplies that severely limit capacity at many labs.
Only now does the U.S. have the capacity to do 110,000 to 135,000 tests daily, far short of the 1 million a day that Howard Forman, director of the Yale School of Public Health’s health-care management program, said would make him “feel much more confident in where we’re going.”

Tracking Cases

Contact tracing presents its own challenges, requiring armies of trained staff. It’s tedious and time-consuming work to find those who have been near an infected person, direct them to testing or treatment or help them self-isolate, and follow up.
To do so, North Dakota has re-purposed an app called The Bison Tracker, built to help fans of the North Dakota State University Bison football team follow their progress on a 1,000-mile drive to the league’s championship game in Texas.
In Massachusetts, an April 3 announcement about its tracing program attracted 9,000 applicants for about 1,000 positions. Expanding the program may produce a silver lining.
“Would I be sad if we ended up hiring 40,000 to 50,000 people in Massachusetts to do this? Absolutely not,” said Partners in Health’s Mukherjee. “We could put people to work and end the epidemic.”
Massachusetts has so far been able to swab roughly 100,000 individuals, an increase made possible with the help of 22 labs. One is the Broad Institute of MIT and Harvard, which pivoted from DNA sequencing to test for Covid-19 in late March. It can now run 2,000 tests a day, and the goal is to get to 10,000 per day — if it can get enough supplies.
“We’re going to learn a lot about how to do this in the next month,” said Stacey Gabriel, who heads up the testing initiative for the institute.
Testing and tracing are also the focus in Utah, which expects to be conducting more than 7,000 tests daily by next week, said Kristen Cox, executive director of the governor’s Office of Management and Budget.

Everyone Helps

The state is working with the private sector to make that happen. A group called Silicon Slopes secured Covid-19 test kits from the Salt Lake City company Co-Diagnostics Inc. and also helped develop a website, TestUtah.com, that launched on April 2 to allow residents to assess their risk for Covid-19.
“The state needed help,” said Mark Newman, founder of Nomi Health, a health-care payments startup. He worked to mobilize Utah’s tech and business leaders to launch the testing effort, paid for by companies and the state.
About 2,000 tests have been conducted so far, said Clint Betts, executive director of Silicon Slopes. The group is in discussions with other states interested in replicating Utah’s approach.
“If every state did what Utah did and put it up as fast as Utah put it up, they’d have an unbelievable amount of testing horsepower,” said Dwight Egan, chief executive officer of Co-Diagnostics.
Utah will follow up with those who are positive to trace their movements and contacts; it recently deployed about 1,200 state employees to local health departments for that task. The state may be as close as two to four weeks away from the “stabilization” stage, Cox said.
“I want to be humble on this. This is a goal, not a guarantee.”
In North Dakota, Governor Doug Burgum said 250 contact tracers have been trained but that 1,000 or more may be needed.
“If we can do that, then we can have the right people isolated and quarantined,” the governor said.
The hope is that the new app will speed up the process. Tim Brookins, a Microsoft engineer in Fargo, tweaked the Bison Tracker to build Care-19, an anonymous location tracker. It had more than 10,000 downloads in its first 36 hours.
The app can serve as a record for people to remind them where they’ve been if they test positive, and to alert them to possible contacts with infected people. They can choose to share information with state health workers.
Burgum said he’s been in touch with officials in Iowa, Nebraska and South Dakota who are considering rolling out the technology.
Yale’s Forman said apps could also be deployed for people to record their symptoms every day, which might help identify outbreaks. But he said any containment plan must include testing and tracing.
“I would love to see some states be in a position to open May 2,” he said. “But they better have a very, very rigorous plan.”
States with relatively few confirmed cases, unlike hot spots including New York, Louisiana and Michigan, still have an opportunity to avert widespread transmission, Centers for Disease Control Director Robert Redfield said in an interview.
“We are preparing to make sure we have the public-health assets so that when that first case gets identified in County A, it’s recognized and then there’s real-time contact tracing and isolation,” Redfield said. “And we need to do that across this whole country so that we can prevent clusters from becoming community transmission.”
https://www.bloomberg.com/news/articles/2020-04-11/states-prepare-test-and-trace-programs-to-reopen-their-economies