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Saturday, April 1, 2023

Generating power with blood sugar

 In type 1 diabetes, the body does not produce insulin. This means that patients have to obtain the hormone externally to regulate their blood sugar levels. Nowadays, this is mostly done via insulin pumps that are attached directly to the body. These devices, as well as other medical applications such as pacemakers, require a reliable energy supply, which at present is met primarily by power from either single-use or rechargeable batteries.

Now, a team of researchers led by Martin Fussenegger from the Department of Biosystems Science and Engineering at ETH Zurich in Basel have put a seemingly futuristic idea into practice. They have developed an implantable fuel cell that uses excess blood sugar (glucose) from tissue to generate electrical energy. The researchers have combined the fuel cell with artificial beta cells developed by their group several years ago. These produce insulin at the touch of a button and effectively lower blood glucose levels much like their natural role models in the pancreas.

"Many people, especially in the Western industrialised nations, consume more carbohydrates than they need in everyday life," Fussenegger explains. This, he adds, leads to obesity, diabetes and cardiovascular disease. "This gave us the idea of using this excess metabolic energy to produce electricity to power biomedical devices," he says.

Fuel cell in tea bag format

At the heart of the fuel cell is an anode (electrode) made of copper-based nanoparticles, which Fussenegger's team created specifically for this application. It consists of copper-based nanoparticles and splits glucose into gluconic acid and a proton to generate electricity, which sets an electric circuit in motion.

Wrapped in a nonwoven fabric and coated with alginate, an algae product approved for medical use, the fuel cell resembles a small tea bag that can be implanted under the skin. The alginate soaks up body fluid and allows glucose to pass from the tissue into the fuel cell within.

A diabetes network with its own power supply

In a second step, the researchers coupled the fuel cell with a capsule containing artificial beta cells. These can be stimulated to produce and secrete insulin using electric current or blue LED light. Fussenegger and his colleagues already tested such designer cells some time ago (see ETH News, 8 December 2016).

The system combines sustained power generation and controlled insulin delivery. As soon as the fuel cell registers excess glucose, it starts to generate power. This electrical energy is then used to stimulate the cells to produce and release insulin into the blood. As a result, blood sugar dips to a normal level. Once it falls below a certain threshold value, the production of electricity and insulin stops.

The electrical energy provided by the fuel cell is sufficient not only to stimulate the designer cells but also to enable the implanted system to communicate with external devices such as a smartphone. This allows potential users to adjust the system via a corresponding app. A doctor could also access it remotely and make adjustments. "The new system autonomously regulates insulin and blood glucose levels and could be used to treat diabetes in the future," Fussenegger says.

A long, uncertain road to market maturity

The existing system is only a prototype. Although the researchers have successfully tested it in mice, they are unable to develop it into a marketable product. "Bringing such a device to market is far beyond our financial and human resources," Fussenegger says. This would call for an industry partner with the appropriate resources and know-how.

Journal Reference:

  1. Debasis Maity, Preetam Guha Ray, Peter Buchmann, Maysam Mansouri, Martin Fussenegger. Blood‐Glucose‐Powered Metabolic Fuel Cell for Self‐Sufficient BioelectronicsAdvanced Materials, 2023; DOI: 10.1002/adma.202300890

Indian capital to boost COVID-19 testing amid jump in daily cases

 New Delhi will ramp up testing for COVID-19 and encourage the increased use of masks, a local minister said on Thursday, after India recorded its highest daily case count in nearly six months.

India recorded 3,016 new cases of the coronavirus in the last 24 hours, the federal health ministry said on Thursday, its highest daily case count since Oct. 3, a Reuters tally showed.

The national capital territory of New Delhi recorded 300 new cases in a day, the local government said late on Wednesday, the highest since August last year, according to local media.

"The positivity rate is above 10% in Delhi, but the number of tests are low, which is why there is no reason to panic. We have issued an advisory asking people to wear masks if they have flu-like symptoms and in hospitals," Saurabh Bhardwaj, Delhi's health minister told reporters after an emergency meeting of the local government to discuss the rising cases.

India has recorded more than 44 million cases of COVID-19 since the start of the pandemic three years ago, the second-highest tally after the United States.

https://www.yahoo.com/news/indian-capital-boost-covid-19-111108845.html

Lilly says experimental Alzheimer's drug reduces amyloid in small study

 Eli Lilly and Co on Friday said early data from the first human study of its next-generation Alzheimer's treatment showed that it lowered levels of toxic amyloid plaques in the brains of people in the earliest stages of the mind-wasting disease.

The higher the dose of the antibody drug, the larger the effect, Lilly said. The treatment, remternetug, was given by intravenous infusion but has the possibility of a more convenient method of administration via subcutaneous injection.

The Indianapolis-based drugmaker is launching a Phase III study of the experimental antibody, but declined to comment on which doses will be selected for larger, later-stage trials.

"We are still trying to explore some of that," said Dawn Brooks, Lilly's global development leader for remternetug. She said the company's goal is to understand how best to balance dose level and treatment duration with safety.

Lilly, at a medical conference in Gothenburg, Sweden, presented interim data from 41 study participants. It showed that amyloid clearance was reached by 75% of the 24 patients who received remternetug at the three highest tested doses.

The most common treatment-related adverse side effect was a type of brain swelling known as ARIA-E, which was observed in 10 participants, with one patient discontinuing treatment due to a serious adverse event.

Eli Lilly is expected to announce before the end of June results from a Phase III trial designed to show the impact on cognition of donanemab, an amyloid-lowering antibody further along in development that is given by intravenous (IV) infusion.

Two IV Alzheimer's drugs developed by partners Eisai Co Ltd and Biogen Inc, Leqembi and Aduhelm, have been approved by the U.S. Food and Drug Administration under the agency's accelerated review program, based on evidence of their ability remove amyloid plaques.

Leqembi is currently undergoing the FDA's standard review process, which will weigh the drug's impact on cognitive function. Trial results published last year showed that, in patients with early Alzheimer's, Leqembi reduced the rate of cognitive decline by 27% compared with a placebo.

More than 6 million Americans are living with Alzheimer's, and by 2050 the number is projected to rise to nearly 13 million, according to the Alzheimer's Association.

Brooks said that sharing its early remternetug data "reinforces Lilly's commitment and investment in the Alzheimer's disease space ... This is not just going to be one and done." 

https://finance.yahoo.com/news/lilly-says-experimental-alzheimers-drug-123000825.html

Warnings Unheeded Now Threaten Our Fundamental Freedoms

by Bruce Abramson via RealClearPolitics.com,

The First Amendment is at a critical juncture. Recent congressional hearings on the Twitter Files brought the matter into full public view. Freedom of speech and of the press are hanging by a precarious thread. Do we want a future in which information flows freely, or one in which an information elite controls those flows “for our own good?” The choices we make over the next few years will determine which of those futures we get.

It’s tragic that we have let the problem reach this dangerous state. What heightens the tragedy, however, is that the war against America’s most cherished freedoms was predictable and preventable. If those of us who value freedom want to win, we’re going to need a strategy grounded in a clear understanding of what’s happening and why.

The Twitter Files story is shocking. Allegations that big tech and social media manipulate information have been around for as long as we’ve had tech and social media companies. Allegations of bias among the mainstream media are even older. In recent years, however, both the allegations and the supporting evidence have ratcheted upward to unprecedented levels.

When Elon Musk acquired Twitter, he opened his company’s internal archives to scrutiny. He assembled a team of journalists with a curious pedigree: registered Democrats with a distaste for Donald Trump and his supporters, whose track records skewed considerably left of center, and whose recent work has demonstrated deep concern about the politicization of journalism.

Musk gave them unfettered access. They found a deep, broad, and disturbing pattern of collaboration between big government and big tech designed to promote “official stories” on multiple issues, throttle competing theories and arguments, and sanction those who dared to question government propaganda.

When two of those journalists – Matt Taibbi and Michael Shellenberger – testified before Congress, their Democratic inquisitors sought to belittle their credentials, question their motives, and tar them as part of some Republican-funded, far-right conspiracy. The still-left-leaning journalists are trying to absorb their shock at the depths to which the formerly civil-libertarian left has fallen.

Far from shocking, however, that fall was predictable – and predicted. In 2001, amidst the public disgust with tech companies following the collapse of the dotcom bubble, I set out to make sense of life during the transition from the late industrial age to the early information age. I analyzed what I called the first four front-page stories of the information age: the dotcom bubble, the Microsoft antitrust trial, the rise of open-source software, and the Napster-driven wars over digital music. Contrary to popular opinion of the time, I believed that these stories were far from distinct. I saw them as four manifestations of a single underlying phenomenon. My goal was to understand that phenomenon.

I found it. It appeared most clearly in the digital music arena, but it ran through all four stories – and through much that has happened since. It appears just as clearly in today’s war on free speech. It involves an entirely predictable pattern of opportunity, action, and reaction.

The starting point is digitization and quantification. The Internet changed the economics of information. Throughout human history, information was scarce, hard to acquire, and expensive to process. Skilled professionals – spies, scholars, lawyers, accountants, clerics, doctors – could command a premium for their knowledge. When the Internet went public, anything that could be digitized and quantified suddenly flowed freely. Information was there for the asking. The premium shifted to filtering – the ability to discard unwanted information and arrange what remained.

Economic shifts generate massive opportunities for creative, entrepreneurial people and bring glorious benefits to millions of consumers. The Internet was no exception in this regard, and neither was the predictable backlash against it. Anything that benefits new businesses and empowers consumers is a warning shot across the bow of powerful incumbents who’d grown accustomed to serving those consumers in a predictable, profitable, manner.

In the music industry, anything that let individual consumers share digital music files reduced the revenues, profits, power, and control of record labels. Pre-digitization, these powerful incumbents determined what music got recorded and how it was packaged, distributed, presented, and priced. It was a comfortable business model that gave us the music industry “as we knew it.” The Internet undermined it entirely.

Powerful incumbents never fade quietly into the night when challenged. They fight, using whatever weapons they can muster. In our society, the most effective ways to undermine new technological and economic opportunities tend to lie in law, regulation, and public policy. The record labels fought – largely successfully – to apply and reinterpret existing laws and to change laws in ways favorable to their interests.

There’s the pattern: Technology creates opportunities. New businesses exploit those opportunities. Consumers benefit. Powerful incumbents fear their loss of control. Threatened incumbents seek allies in government. Government changes laws and regulations to protect incumbent interests. Media campaigns “educate” the public on the merits of the new policies. The new laws ensure that the next wave of technological change runs largely through the powerful incumbents, rather than against them.

By 2003, I had distilled this pattern, showed numerous ways that it had already unfolded, predicted that it would soon hit parts of our economy and our lives far more significant than the music industry, and suggested some ways that we might prepare ourselves for the coming battles.

It took another two years to get my analysis published. It went largely unnoticed. Twelve years later, then-Senator Ben Sasse described the ways that this pattern had forever disrupted the dynamics of employment. This, too, went largely unnoticed.

Today, we see that disruptive pattern threatening the most basic of our civil liberties. Its manifestation in the arenas of speech, propaganda, and censorship is clear. Consider how each step in the process I identified above has played out here:

  • Technology creates opportunitiesThe Internet opened entirely new vistas for the creation and exchange of ideas, information, theories, opinions, propaganda, and outright lies.

  • New businesses exploit those opportunitiesThe companies founded since 1995 that created and control the world’s most important conduits for information have joined the ranks of history’s most powerful entities.

  • Consumers benefitThe centrality of these communication systems to our lives (for better or for worse) proves that they confer real value.

  • Powerful incumbents fear their loss of controlThe twin political shocks of 2016 – Brexit and Donald Trump – highlighted the extent to which official channels had lost control of the narrative. With the entirety of elite media, government, big business, and the intelligentsia aligned behind Remain and Hillary, the newly empowered masses understood – for the first time – that there were viable alternatives to the official story.

  • Threatened incumbents seek allies in governmentA coalition of elite forces assembled quickly, laser-focused on stomping out the populist threat. Masses empowered to conduct their own analyses, draw their own conclusions, and share their opinions among themselves threatened the stability of the power structure “as we know it.”

  • Government changes laws and regulations to protect incumbent interestsPrior to Musk’s Twitter, the entirety of Silicon Valley committed itself to “protecting” the public from “disinformation,” roughly defined as anything that threatened to undermine an official, sanctioned narrative. Allies throughout the administrative state, Congress, and the Biden White House are working to embed those “protections” in law.

  • Media campaigns “educate” the public on the merits of the new policies. The same mainstream media that vilified Napster, Grokster, and Peer-to-Peer (P2P) file sharing is now working to turn public opinion against the evil purveyors of alleged “disinformation.”

  • The new laws ensure that the next wave of technological change runs largely through the powerful incumbents, rather than against them. We’re now entering the stage in which censoring technologies provide strong, effective, and legally mandated protection against anything that runs against the “consensus” of government propaganda or enlightened elite opinion.

The backlash is nearing its last stages. We’re rapidly heading towards locking in a technological, economic, and legal regime of information control, censorship, surveillance, and vilification.

That’s the predictable pattern. That’s the threat. That’s the precipice on which we now stand. We’re on the verge of deciding whether we want to restore information monopoly and dominance to a powerful elite, or reverse the trajectory of recent law, regulation, and public policy to enshrine an architecture of open discourse.

Will the information age be an era of informed, empowered citizens – or an era of a dominant, information-controlling elite? Stay tuned. That’s the question we need to answer.

*  *  *

Bruce Abramson, PhD, JD, is a principal at JBB&A Strategies and B2 Strategic, a director of the American Center for Education and Knowledge, and author of the forthcoming book "The New Civil War: Exposing Elites, Fighting Utopian Leftism, and Restoring America" (RealClear Publishing, 2021).


Medtronic, DaVita launch Mozarc Medical, aimed at new solutions for kidney failure

  Medtronic plc (NYSE: MDT) and DaVita Inc. (NYSE: DVA) today announced the launch of Mozarc Medical—an independent new company committed to reshaping kidney health and driving patient-centered technology solutions.

"Mozarc Medical's focus will be on meaningful and innovative kidney health technologies that improve the overall patient experience and increase access to care globally," said Ven Manda, CEO of Mozarc Medical. "At a time when patient preferences are evolving and in-home kidney care is on the rise, Mozarc Medical is uniquely positioned to better serve patients with kidney disease around the world."

Central to the creation of Mozarc Medical is its global workforce, which includes the former Medtronic Renal Care Solutions (RCS) business (now part of Mozarc Medical) and other industry-leading talent hired to advance the new company's strategic mission. In addition to Manda, a 28-year veteran of Medtronic, the former RCS leadership team has also transitioned to serve as Mozarc Medical's leadership team.

"With proven industry leadership, a strong product portfolio and R&D pipeline, and strategic investment from Medtronic and DaVita, Mozarc Medical is well-positioned for long-term success," said Manda. "I look forward to unlocking the full potential of our new company, with a dedicated global team and innovative pipeline that will transform kidney care."

Under the terms of the agreement, which was announced last year, Mozarc Medical is co-owned by Medtronic and DaVita, each with equal equity stakes. Through the first three quarters of Medtronic's fiscal year 2023, the RCS business had revenue of $64 million$63 million, and $70 million, respectively.

"The launch of Mozarc Medical holds tremendous promise to improve the lives of patients living with kidney disease as it seeks to revolutionize the approach to home dialysis by improving accessibility, ease of use, and clinical performance," said Dr. Mahesh Krishnan, group vice president of research and development at DaVita. "Our investment in this venture is born from our decades-long commitment to advancing kidney care, and our aim is that it will fuel patient-centric solutions that may not have otherwise been possible."

More information about Mozarc Medical can be found at http://www.mozarcmedical.com.

https://www.marketscreener.com/quote/stock/DAVITA-INC-12378/news/Medtronic-DaVita-launch-Mozarc-Medical-aimed-at-introducing-new-solutions-for-patients-with-kidney-43400329/

Majority Of Americans Question The Value Of College

 A new Wall Street Journal-NORC poll reveals that a majority of Americans believe a college degree isn't worth the cost and time. Sliding confidence in the higher education system indicates that the American Dream can be achieved without a college degree. This is an ominous sign for liberal professors teaching meaningless programs, particularly in the humanities.

The poll, conducted with NORC at the University of Chicago, found that 56% of Americans believe a four-year degree is a poor investment, while 42% still have confidence in colleges.

Source: Wall Street Journal

The majority of this skepticism is found among individuals aged 18-34, and those with degrees are among the groups whose views have soured about college. And why is that?

Source: WSJ

Well, over 43 million individuals have federal student loans totaling $1.6 trillion. Many of these individuals were assured that obtaining a degree would secure them a high-paying job. Yet, in the current job market, where artificial intelligence is automating vast parts of the economy, some folks with tens of thousands of dollars in student debt are working two and even three low-paying, low-skilled jobs. 

For some context of just how quickly the belief in higher education has slumped, in 2013, 53% of Americans had a favorable view of college, while 40% did not. By 2017, the percentage of Americans who believed a four-year degree would result in good jobs fell to 49%, with 47% holding the opposite opinion. Much of the sentiment shift occurred after the 2007–2008 financial crisis. 

"These findings are indeed sobering for all of us in higher education, and in some ways, a wake-up call," said Ted Mitchell, the president of the American Council on Education, which has more than 1,700 institutions of higher education as members. 

What bothers us is Mitchell's next comment:

"We need to do a better job at storytelling, but we need to improve our practice, that seems to me to be the only recipe I know of regaining public confidence."

Maybe the "better job at storytelling" could come if meaningless programs, particularly in the humanities, were removed from the curriculum. Universities need to stop catering to a few radical liberals and teach skills and critical thinking that will translate into a lifetime of success for the student. The current higher education model has failed, and the college grads working as bartenders and or 2-3 jobs are the result of a failed system. 

And if universities don't change their tune and public opinion continues to slide. The bust in the higher education bubble will broaden:

Young people realize that a college degree is not always necessary to succeed in today's economy. Some individuals earn over $100k per year in specialized trades, such as electricians, plumbers, and or welders -- many of them have very little debt. 

https://www.zerohedge.com/markets/sliding-confidence-majority-americans-question-value-college

Saudi Arabia Joins Shanghai Cooperation Organization As It Embraces China

 While the US continues to splinter and cannibalize itself as it turns into a third world country, China is expanding its zone of economic and military influence that covers virtually all global commodity producers as it prepares for the next stage in the Sino-US cold war.

On Wednesday, Saudi Arabia's cabinet approved a decision to join the Shanghai Cooperation Organization, as Riyadh builds a long-term partnership with China despite - or perhaps due to - US security concerns. Saudi Arabia has approved a memorandum on granting the kingdom the status of a dialogue partner in the Shanghai Cooperation Organization (SCO), state news agency SPA said.

The SCO is a political and security union of countries spanning much of Eurasia, including China, India and Russia. Formed in 2001 by Russia, China and former Soviet states in Central Asia, the body has been expanded to include India and Pakistan, with a view to playing a bigger role as counterweight to Western influence in the region. Iran also signed documents for full membership last year.

Joining the SCO was discussed during a visit by Chinese President Xi Jinping to Saudi Arabia last December, sources told Reuters, adding that dialogue partner status will be a first step within the organization before granting the kingdom full membership in the mid-term.

The decision followed an announcement by Saudi Aramco which raised its multi-billion dollar investment in China on Tuesday, by finalizing a planned joint venture in northeast China and acquiring a stake in a privately controlled petrochemical group.

Participants of the Shanghai Cooperation Organization summit attend an extended-format meeting of heads of SCO member states in Samarkand, Uzbekistan

Riyadh's growing ties with Beijing have raised security concerns in Washington, its traditional ally but increasingly less so, especially following Biden's catastrophic attempts to force OPEC+ to boost oil production, an overture which backfired spectacularly and to global humiliation by the Biden admin.

Meanwhile, Washington says Chinese attempts to exert influence around the world will not change U.S. policy toward the Middle East, which of course is a lie.

Saudi Arabia and other Gulf states have voiced concern about what they see as a withdrawal from the region by main security guarantor the United States, and have moved to diversify partners, shifting their alliance to the biggest US challenger in the global arena. Washington says it will stay an active partner in the region.

Countries belonging to the organisation plan to hold a joint "counter-terrorism exercise" in Russia's Chelyabinsk region in August this year.

https://www.zerohedge.com/markets/saudi-arabia-joins-shanghai-cooperation-organization-it-embraces-china