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Friday, May 3, 2024

Open the Overton Window

 You may have heard of the “Overton window.”

The concept of the Overton window caught on in professional culture, particularly those seeking to nudge public opinion, because it taps into a certain sense that we all know is there.

There are things you can say and things you cannot say, not because there are speech controls (though there are) but because holding certain views makes you anathema and dismissable. This leads to less influence and effectiveness.

The Overton window is a way of mapping sayable opinions.

The goal of advocacy is to stay within the window while moving it just ever so much. For example, if you’re writing about monetary policy, you should say that the Fed should not immediately reduce rates for fear of igniting inflation.

You can really think that the Fed should be abolished but saying that is inconsistent with the demands of polite society. That’s only one example of a million.

To notice and comply with the Overton window is not the same as merely favoring incremental change over dramatic reform. There is not and should never be an issue with marginal change.

That’s not what’s at stake.

To be aware of the Overton window, and fit within it, means to curate your own advocacy. You should do so in a way that’s designed to comply with a structure of opinion that’s pre-existing as a kind of template we’re all given.

It means to craft a strategy specifically designed to game the system, which is said to operate according to acceptable and unacceptable opinionizing.

In every area of social, economic and political life, we find a form of compliance with strategic considerations seemingly dictated by this window. There’s no sense in spouting off opinions that offend or trigger people because they’ll just dismiss you as not credible.

But if you keep your eye on the window — as if you can know it, see it, manage it — you might succeed in expanding it a bit here and there and thereby achieve your goals eventually.

The mission here is always to let considerations of strategy run alongside — perhaps even ultimately prevail in the short run — over issues of principle and truth, all in the interest of being not merely right but also effective.

Everyone in the business of affecting public opinion does this, all in compliance with the perception of the existence of this window.

It’s how ideas move from unthinkable to radical to acceptable to sensible to popular to become policy.

The concept was named for Joseph Overton, who worked at the Mackinac Center for Public Policy in Michigan. He found that it was useless in his work to advocate for positions that he could not recruit politicians to say from the legislative floor or on the campaign trail.

By crafting policy ideas that fit within the prevailing media and political culture, however, he saw some successes about which he and his team could brag to the donor base. A wise intellectual shepherd will manage this transition carefully from one stage to the next until victory and then take on a new issue.

The core intuition here is rather obvious. It probably achieves little in life to go around screaming some radical slogan about what all politicians should do if there is no practical means to achieve it and zero chance of it happening.

But writing well-thought-out position papers with citations backed by large books by Ivy League authors and pushing for changes on the margin that keep politicians out of trouble with the media might move the window slightly and eventually enough to make a difference.

Beyond that example, which surely does tap into some evidence in this or that case, how true is this analysis?

Read on for the answer.


Is the Overton Window Real?

By Jeffrey Tucker

First, the theory of the Overton window presumes a smooth connection between public opinion and political outcomes. During most of my life, that seemed to be the case or, at least, we imagined it to be the case. Today this is gravely in question.

Politicians do things daily and hourly that are opposed by their constituents — fund foreign aid and wars for example — but they do it anyway due to well-organized pressure groups that operate outside public awareness. That’s true many times over with the administrative and deep layers of the state.

In most countries, states and elites that run them operate without the consent of the governed. No one likes the surveillance and censorial state but they are growing regardless, and nothing about shifts in public opinion seem to make any difference.

It’s surely true that there comes a point when state managers pull back on their schemes for fear of public backlash but when that happens or where, or when and how, wholly depends on the circumstances of time and place.

Second, the Overton window presumes there’s something organic about the way the window is shaped and moves. That is probably not entirely true either. Revelations of our own time show just how involved are major state actors in media and tech, even to the point of dictating the structure and parameters of opinions held in the public, all in the interest of controlling the culture of belief in the population.

I had read Manufacturing Consent by Noam Chomsky and Edward Herman when it came out in 1988 and found it compelling. It was entirely believable that deep ruling-class interests were more involved than we know about what we are supposed to think about foreign-policy matters and national emergencies, and, further, entirely plausible that major media outlets would reflect these views as a matter of seeking to fit in and ride the wave of change.

What I had not understood was just how far-reaching this effort to manufacture consent is in real life.

What illustrates this perfectly has been media and censorship over the pandemic years in which nearly all official channels of opinion have very strictly reflected and enforced the cranky views of a tiny elite. Honestly, how many actual people in the U.S. were behind the lockdowns policy in terms of theory and action? Probably fewer than 1,000. Probably closer to 100.

But thanks to the work of the Censorship Industrial Complex, an industry built of dozens of agencies and thousands of third-party cutouts including universities, we were led to believe that lockdowns and closures were just the way things are done. Vast amounts of the propaganda we endured was top down and wholly manufactured.

Third, the lockdown experience demonstrates that there is nothing necessarily slow and evolutionary about the movement of the window. In February 2020, mainstream public health was warning against travel restrictions, quarantines, business closures and the stigmatization of the sick. A mere 30 days later, all these policies became acceptable and even mandatory belief.

Not even Orwell imagined such a dramatic and sudden shift was possible!

The window didn’t just move. It dramatically shifted from one side of the room to the other, with all the top players against saying the right thing at the right time, and then finding themselves in the awkward position of having to publicly contradict what they had said only weeks earlier.

The excuse was that “the science changed” but that is completely untrue and an obvious cover for what was really just a craven attempt to chase what the powerful were saying and doing.

It was the same with the vaccine, which major media voices opposed so long as Trump was president and then favored once the election was declared for Biden. Are we really supposed to believe that this massive switch came about because of some mystical window shift or does the change have a more direct explanation?

Fourth, the entire model is wildly presumptuous. It is built by intuition, not data, of course. And it presumes that we can know the parameters of its existence and manage how it is gradually manipulated over time.

None of this is true. In the end, an agenda based on acting on this supposed window involves deferring to the intuitions of some manager who decides that this or that statement or agenda is “good optics” or “bad optics,” to deploy the fashionable language of our time.

The right response to all such claims is: You don’t know that. You are only pretending to know but you don’t actually know. What your seemingly perfect discernment of strategy is really about concerns your own personal taste for the fight, for controversy, for argument, and your willingness to stand up publicly for a principle you believe will very likely run counter to elite priorities. That’s perfectly fine, but don’t mask your taste for public engagement in the garb of fake management theory.

It’s precisely for this reason that so many intellectuals and institutions stayed completely silent during lockdowns when everyone was being treated so brutally by public health. Many people knew the truth — that everyone would get this bug, most would shake it off just fine and then it would become endemic — but were simply afraid to say it. Cite the Overton window all you want but what is really at issue is one’s willingness to exercise moral courage.

The relationship between public opinion, cultural feeling and state policy has always been complex, opaque and beyond the capacity of empirical methods to model. It’s for this reason that there is such a vast literature on social change.

We live in times in which most of what we thought we knew about the strategies for social and political change have been blown up. That’s simply because the normal world we knew only five years ago — or thought we knew — no longer exists. Everything is broken, including whatever imaginings we had about the existence of this Overton window.

What to do about it? I would suggest a simple answer. Forget the model, which might be completely misconstrued in any case. Just say what is true, with sincerity, without malice, without convoluted hopes of manipulating others. It’s a time for truth, which earns trust.

Only that will blow the window wide open and finally demolish it forever.

Jeffrey Tucker is president of Brownstone Institute and senior economics columnist at Epoch Times.

https://dailyreckoning.com/open-the-overton-window/

Almost Half Of Health Care Workers Hesitant To Take COVID-19 Boosters: Study

 by Naveen Athrappully via The Epoch Times (emphasis ours),

Approximately half of the health care workers in a Polish study were found to be averse to taking COVID-19 booster shots, with one of the reasons for this hesitancy being their negative experiences with previous vaccinations.

The peer-reviewed study, published in the Vaccines journal on April 29, examined factors underlying “hesitancy to receive COVID-19 booster vaccine doses” among health care workers (HCW) in Poland. Almost 50 percent of the participants were identified as being wary of the boosters. “Our study found that 42 percent of the HCWs were hesitant about the second booster dose, while 7 percent reported no intent to get vaccinated with any additional doses.”

As reasons for not vaccinating, participants most frequently highlighted lack of time, negative experiences with previous vaccinations, and immunity conferred by past infections.

The study involved 69 healthcare workers composed of nurses, midwives, physicians, other health associate professionals, and administrative staff.

At the time of enrollment, 47 had a history of lab-confirmed COVID-19 infection and 31 had at least one comorbidity, a situation where a person suffers from more than one disease or medical condition at the same time.

Over 92 percent of study participants received at least one vaccine booster, with 50.73 percent getting two doses. Five out of the 69 HCWs did not take any boosters.

“Booster hesitancy among health professionals (physicians, nurses, and midwives) was lower than among administrative staff and others. Almost 79 percent of the physicians had received two COVID-19 vaccine booster doses. However, apart from physicians, about half of the HCWs from each occupation group were hesitant about the second booster dose.”

“The highest number of HCWs without any vaccine boosters was observed among administration personnel.”

HCWs in the age groups of 31-40 and 41-50 were found to be the most skeptical about taking the second booster shot. Thirty-four out of the 69 HCWs provided reasons for their COVID-19 booster vaccine hesitancy.

Two of the health care workers who did not take booster shots said their decision was based on their personal experience with the vaccines.

They reported negative experiences with past COVID-19 vaccination and stated that the natural immunity developed after SARS-CoV-2 infection could protect them against COVID-19, which, overall, does not pose serious health risks,” the study said.

“Responses from HCWs who received only one COVID-19 booster dose can be categorized into two themes: (i) influences arising from personal perceptions of the COVID-19 vaccine and disease prevention and (ii) issues directly related to vaccination and its safety.”

Six health care workers reported suffering negative adverse effects after previously taking COVID shots. Four had safety concerns about the vaccines.

In an earlier study conducted by the researchers, COVID-19 antibody levels among HCWs after receiving the mandatory primary vaccine series were found to have decreased by around 90 to 95 percent within seven months of vaccination. However, “none of the HCWs contracted COVID-19,” it said.

The current study was funded by the Institute of Bioorganic Chemistry Polish Academy of Sciences. The authors of the study reported no conflicts of interest.

Vaccine Concerns, Harms

Other studies have also explored vaccine hesitancy among health care workers. A March 2023 study that looked at HCWs from Cameroon and Nigeria found that COVID-19 vaccine hesitancy was “high and broadly determined by the perceived risk of COVID-19 and COVID-19 vaccines on personal health, mistrust in COVID-19 vaccines, and uncertainty about colleagues’ vaccine acceptability.”

An April 2022 study found that “a concern for vaccine side effects” and “the belief that the vaccines are inadequately studied” were some of the key reasons for vaccine hesitancy among health care workers.

A May 2022 analysis at BMJ Global Health warned that indulging in policies like mandatory vaccination “may cause more harm than good.”

“Current mandatory vaccine policies are scientifically questionable and are likely to cause more societal harm than good,” it said.

“Current policies may lead to a widening of health and economic inequalities, detrimental long-term impacts on trust in government and scientific institutions, and reduce the uptake of future public health measures, including COVID-19 vaccines as well as routine immunizations.”

The analysis recommended that vaccines should only be mandated “sparingly and carefully to uphold ethical norms and trust in institutions.”

During Sen. Ron Johnson’s (R-Wis.) roundtable discussion on COVID-19 vaccines on Feb. 26, researcher Raphael Lataster, associate lecturer at the University of Sydney, claimed that data from Pfizer and Moderna COVID-19 vaccine clinical trials exaggerated the efficacy of the shots.

The data exaggeration could make an ineffective vaccine have a perceived effectiveness of up to 48 percent, he stated.

Meanwhile, a Jan. 27 narrative review found that repeated COVID-19 vaccination may end up boosting the likelihood of experiencing COVID-19 infections and other pathologies. Taking multiple vaccine doses could trigger higher levels of IgG4 antibodies and impair activating white blood cells that protect a person from infections and cancers.

While booster doses have been recommended to enhance and extend immunity, especially in the face of emerging variants, this recommendation is not based on proven efficacy, and the side effects have been neglected,” the paper said.

In an interview with EpochTV’s “American Thought Leaders” program last year, clinical pathologist Dr. Ryan Cole said that DNA contamination in some of the COVID-19 vaccines could be behind an increase in cancers. He pointed to “turbo cancers,” referring to the phenomenon of cancer symptoms arising faster.

“Now I’m seeing the solid tissue cancers at rates I’ve never seen ... Patients that were stable, or cancer-free for one, two, five, ten years and their cancer’s back, it’s back with a vengeance and it’s not responding to the traditional therapies,” he said.

https://www.zerohedge.com/medical/almost-half-health-care-workers-hesitant-take-covid-19-boosters-study

Biden Admin Covertly Pursued Gender Affirming Care For Kids In States Where Banned

 America First Legal revealed documents on Thursday from its lawsuit against the U.S. Department of Health and Human Services (HHS), showcasing emails from Assistant Secretary for Health Rachel Levine and indicating that the Biden Administration has engaged privately with "gender affirming care providers" from states that have outlawed these practices, pledging federal support to counteract such state laws.

In particular, Levine expressed significant concern for the LGBTI+ community in Idaho, emphasizing ongoing efforts to challenge these state measures nationally, the site pointed out. The documents were acquired through a Freedom of Information Act (FOIA) request concerning Levine’s correspondence about pediatric transgender clinics.

Previously, in March 2023, Levine stated that the federal backing for transitioning children was comprehensive, even at presidential levels, and framed any opposition as politically motivated. The newly revealed records elaborate on the administration's covert operations with advocates to push this agenda.


One notable communication from June 2022 involves HHS Regional Director Ingrid Ulrey discussing an Idaho meeting about impending legislation aimed at prohibiting certain medical treatments for minors. Ulrey's message to Levine highlighted her empathy for Idaho's LGBTQ community, particularly in light of legislative efforts she described as harmful.

Among other things, the report noted that in her memo, Ulrey highlighted concerns about the impact of Idaho's proposed law on "Gender Affirming Care" (GAC), including a doctor shortage and the high costs of such treatments without insurance subsidies.

She noted that only one provider was offering GAC to a significant state prison population, with a few others too intimidated to attend a meeting or preferring to stay under the radar. Ulrey also relayed that the care providers had specific definitions of GAC, controversially suggesting the removal of parental consent requirements, which could include requiring consent from just one parent or both if divorced. This approach appears to be advocated by a high-ranking HHS official following discussions with these providers.

Ulrey's discussions with "gender-affirming care providers" led to a disturbing proposal to simplify legal barriers, including reducing parental consent requirements for such treatments, according to America First Legal

Following these meetings, a high-ranking HHS official advocated for the removal of parental consent as part of the definition of "gender-affirming care."

The meeting's summary called for federal intervention to override state laws restricting such care, with suggestions for using Medicaid to mandate coverage across all states and queries about providing such care in prisons, indicating a push to extend "gender-affirming care" despite local restrictions.

The summary also reflected provider concerns about parental rights obstructing children's access to these treatments. On June 5, 2022, Assistant Secretary Levine expressed ongoing support for the LGBTI+ community in Idaho, promising to continue advocacy efforts nationally.

Further details emerged from a June 2022 roundtable in Anchorage, Alaska, where discussions focused on integrating mental health counselors in schools amidst concerns about parental opposition. A local clinic, Identity, Inc., was noted for providing non-surgical gender-affirming care, with surgical treatments sought outside Alaska. The report also mentioned potential local legislation in Anchorage impacting transgender individuals' participation in school sports, signaling continued legislative challenges for the transgender community.

America First Legal Senior Advisor Ian Prior commented: “The Biden Administration is leveraging the full power of the federal government to engage in an anti-science war on reality, with America’s children as the collateral damage. While European nations are drastically pulling back on these dangerous experiments and a number of states are legislating against them, the Biden Administration is plowing full steam ahead in its goal of redefining the foundations of biology, from the doctors’ offices to the athletic fields. This comes even as the United States Supreme Court has held that states have a right to enact such legislation. The Biden Administration is supporting crimes against humanity, and America First Legal will continue to fight back until these dangerous practices end.”

You can read the full trove of emails here.

https://www.zerohedge.com/markets/biden-admin-pursued-gender-affirming-care-kids-states-where-practice-banned-foia-reveals

Cuellar, wife indicted on bribery charges

 Rep. Henry Cuellar (D-Texas) and his wife were indicted Friday on charges related to allegedly accepting nearly $600,000 in bribes and laundering the funds.

The indictment filed by the Justice Department (DOJ) details payments Cuellar allegedly accepted from an oil company owned by the Azerbaijan government and a Mexican bank.

“The bribe payments were allegedly laundered, pursuant to sham consulting contracts, through a series of front companies and middlemen into shell companies owned by Imelda Cuellar, who performed little to no legitimate work under the contracts,” the DOJ wrote in a press release announcing the indictment in the Southern District of Texas.

“In exchange for the bribes paid by the Azerbaijani oil and gas company, Congressman Cuellar allegedly agreed to use his office to influence U.S. foreign policy in favor of Azerbaijan. In exchange for the bribes paid by the Mexican bank, Congressman Cuellar allegedly agreed to influence legislative activity and to advise and pressure high-ranking U.S. Executive Branch officials regarding measures beneficial to the bank.”

The couple both pleaded not guilty in a Houston courtroom Friday morning and were released on a $100,000 bond.

The 14-count indictment details that Henry Cuellar would back Azerbaijan in its conflict with neighboring Armenia, including giving a speech favorable to the country on the House floor.

In his alleged dealings with the unnamed Mexican bank, Cuellar is alleged to have promised to pressure executive branch officials on anti-money laundering enforcement practices — one of the crimes which he now stands accused of. The indictment also says he pledged to support legislation to block federal regulation of the payday lending industry.

The indictment likely refers to Banco Azteca, a subsidiary of Grupo Elektra, a retail and banking company that’s part of a corporate conglomerate led by Mexican billionaire Ricardo Salinas Pliego. In 2012, Grupo Elektra acquired U.S.-based payday lender Advance America.

Henry Cuellar and his wife, Imelda, face a string of charges that could collectively carry more than a decade in jail time.

Among the charges are those for acting as an agent of a “foreign principle,” bribery and conspiracy to commit bribery, wire fraud, and various charges for wire fraud.

Henry Cuellar denied he or his wife did anything wrong in a statement issued before the charges were unsealed.

“I want to be clear that both my wife and I are innocent of these allegations. Everything I have done in Congress has been to serve the people of South Texas,” he said in a statement through his campaign.

“Before I took any action, I proactively sought legal advice from the House Ethics Committee, who gave me more than one written opinion, along with an additional opinion from a national law firm. The actions I took in Congress were consistent with the actions of many of my colleagues and in the interest of the American people.”

He also defended his wife’s professional background, saying “she spent her career working with banking, tax, and consulting. The allegation that she is anything but qualified and hard working is both wrong and offensive.”

Henry Cuellar, who is a co-chair of the Congressional Azerbaijan Caucus, will have to step down from his post as the ranking member on the House Homeland Security Appropriations Subcommittee, House Minority Leader Hakeem Jeffries’s (D-N.Y.) office noted in a statement nodding to House rules.

“Henry Cuellar has admirably devoted his career to public service and is a valued Member of the House Democratic Caucus. Like any American, Congressman Cuellar is entitled to his day in court and the presumption of innocence throughout the legal process,” Jeffries spokeswoman Christie Stephenson said in the statement.

Cuellar’s Texas home and campaign office were searched in January 2022 in relation to the probe, and at the time he said he was not the target of the investigation. The indictment alleges that the couple accepted bribes from December 2014 to November 2021.

The payments to the couple initially went through a Texas-based shell company owned by Imelda Cuellar and two of the couple’s children, according to the indictment. That company received payments from the Azerbaijan energy company of $25,000 per month under a “sham contract,” purportedly in exchange for unspecified strategic consulting and advising services.

“This agreement was a sham used to disguise and legitimate Henry Cuellar’s corrupt agreement to take official acts and acts in violation of his official duties for the benefit of Azerbaijan and to act as an agent of the Government of Azerbaijan in exchange for bribes,” the indictment states.

The indictment also alleges an Azerbaijani diplomat referred to Henry Cuellar in text messages as “el Jefe” or “boss,” and also that a member of Cuellar’s staff sent multiple emails to officials at the State Department pressuring them to renew a U.S. passport for an Azerbaijani diplomat’s daughter.

Cuellar also noted earlier Friday he still plans to seek reelection.

“Let me be clear, I’m running for re-election and will win this November,” he said in his statement. 

The Texas congressman narrowly defeated Democratic primary challenger Jessica Cisneros in the 28th District, which runs along the U.S.-Mexico border. Republicans have a May 28 runoff to determine whom Cuellar will compete against for the swing seat in the majority-Hispanic district.

Chris Flood, Cuellar’s attorney, told The Hill the indictment “reads like a spy novel, but it’s fiction.”

“There is no bribery. There was never a quid pro quo,” he said, something that undercuts the rest of the charges.

Flood also said DOJ erred in bringing the charges ahead of the election, noting the department similarly searched Cuellar’s home just a few months before the 2022 primary.

“Now they’ve issued an indictment which clearly could affect the general election,” Flood said.

Cuellar, a moderate Democrat, has played an interesting role in the party. He’s the only Democrat that doesn’t support abortion rights and frequently bucks the party on border issues and gun regulations.

The indictment makes Cuellar the second lawmaker in the last year to face bribery charges relating to a foreign government alongside his wife. Sen. Bob Menendez (D-N.J.) and his wife are facing trial for accepting bribes and taking action beneficial to the government of Egypt.

https://thehill.com/homenews/4641800-cuellar-wife-indicted-bribery-charges/

Iowa will face lawsuit if it acts on immigration law, DOJ warns

The Department of Justice (DOJ) warned Iowa on Friday that the state will face a lawsuit if it implements an immigration law that forbids people from being in the state if they were previously denied entry into the United States.

The DOJ informed Iowa’s top state officials, Gov. Kim Reynolds and state Attorney General Brenna Bird, that it intends to sue the Hawkeye State by May 7 if it enforces SF 2340, a bill that makes it a crime for a person to be in Iowa if they were previously removed from the U.S. or have outstanding deportation orders. 

Reynolds said the law will be enforced since it is her “duty” to protect Iowa residents. 

“The only reason we had to pass this law is because the Biden Administration refuses to enforce the laws already on the books,” Reynolds said in a Friday post on social platform X. “I have a duty to protect the citizens of Iowa. Unlike the federal government, we will respect the rule of law and enforce it.” 

The DOJ letter — first reported by the Des Moines Register — argued Iowa’s law violates the Constitution and the Immigration and Nationality Act.

“SF 2340 is preempted by federal law and violates the United States Constitution,” Brian Boynton, principal deputy assistant U.S. attorney general, said in a letter that was obtained by The Hill.

Boynton said in the letter the law “effectively creates a separate state immigration scheme,” which “intrudes into a field that is occupied by the federal government and is preempted.”

Bird, like Reynolds, signaled that the state will push ahead with the law despite the DOJ’s request. 

“Not only has Biden refused to enforce federal immigration laws & secure our border, he is now threatening to block states like IA from enforcing our own laws,” Bird said Friday on X

“Our message to Biden is this: IA will not back down & stand by as our state’s safety hangs in the balance. If Biden refuses to stop the border invasion & keep our communities safe, IA will do the job for him.” 

The DOJ’s threat of a lawsuit is not a hollow one.

The department sued Texas earlier this year after it passed a law allowing state law enforcement to effectively carry out immigration duties and deport those perceived to be migrants to Mexico, regardless of their country of origin. The law has been put on hold while litigation continues.

The DOJ also sued Texas after it placed large buoys in the Rio Grande to block migrants crossing the river, and the department also challenged Texas’s placement of concertina wire alongside the border, arguing it interfered with U.S. immigration agents carrying out their jobs.

Those lawsuits, though still working their way through the court system, have been largely successful for the DOJ, with courts siding with the department that immigration enforcement is a power reserved to the federal government.

Nationally, Republicans have gone after President Biden, accusing him of not enforcing federal law on the southern border. 

House Republicans impeached Homeland Security Secretary Alejandro Mayorkas in protest of Biden’s abortion policies in February. The House GOP also derailed a bipartisan deal brokered in the Senate earlier this year that would have imposed new restrictions along the border.

Iowa’s law, which Reynolds signed April 10, will go into effect July 1. 

https://thehill.com/homenews/state-watch/4642211-iowa-will-face-lawsuit-if-it-acts-on-immigration-law-doj-warns/

CG sets new bar in bladder cancer, validating rare biotech IPO success story

 CG Oncology’s late-stage bladder cancer treatment notched a complete response in roughly three-quarters of treated patients, fueling optimism that the company’s Wall Street success story is no fluke.

The oncolytic-virus-based therapeutic company reported Friday that cretostimogene elicited a 75.2% complete response rate in a late-stage trial among 105 evaluable patients with non-muscle invasive bladder cancer (NMIBC). 

The data reported at the American Urological Association annual meeting found that none of the patients reporting a complete response had to get their bladder removed and that 29 patients maintained a complete response for at least a year, with 22 more patients pending evaluation. The median duration of response has not yet been reached as of the April 1 data cutoff, with more durability data expected at the end of the year. There were no grade 3 or higher adverse events reported among patients. 

CG CEO Arthur Kuan called the data “highly encouraging,” particularly given the size of the data set and the 94.5% compliance rate. 

“Ultimately, for patients, we want to give them something that they can adhere to, and come back for the necessary treatments,” Kuan said in an interview ahead of the company’s presentation. 

CG is among a handful of biotechs and pharmas that are looking to advance the bladder cancer market with a diversity of approaches. Cretostimogene is an oncolytic-virus-based monotherapy that infects cancer cells which in turn shed cytokines that draw in the immune system. Aside from the clinical response rate, the therapy is differentiated by working without Bacillus Calmette-Guerin, a vaccine used to treat bladder cancer that’s had supply issues.

Confident in the drug's potential, investors showered CG with a $380 million IPO in late January, the strongest so far in 2024. 

ImmunityBio’s IL-15 agonist was approved to treat NMIBC in late April based on a 62% complete response rate among 77 evaluable patients. Johnson & Johnson’s drug-device combo treatment TAR-200 is also in the mix and in the middle of a phase 3 study after a 77% complete response rate was reported among 30 evaluable patients in phase 2. 

Kuan emphasized that CG’s response rate places it at or close to the top of the food chain and that the company is more than capable of competing in the market without selling off commercial rights to a larger pharma. 

“We are going all in,” he said. “We believe this is an area where the bigger players may not have an edge over the ‘smaller players.’” He credits his confidence to the relationship CG has built with urologists around the country and the fact that he doesn’t expect to need a massive sales force to get the drug to patients. CG plans to submit a new drug application to the FDA in the second half of 2025. 

One potential boost to cretostimogene’s durability could be adding Keytruda, with a taste of data expected at this year’s American Society of Clinical Oncology annual conference. Keytruda was approved to treat NMIBC in 2020 based off a 41% complete response rate.

“The way I-O combos have worked in other indications is we've seen this super long tail,” Kuan said. “We are hoping that that [mechanism of action] and outcome that [pembrolizomab] can do in other indications could translate over here.”  

https://www.fiercebiotech.com/biotech/cg-sets-new-bar-bladder-cancer-validating-rare-biotech-ipo-success-story

Americans Continue To Name Inflation As Top Financial Problem: Gallup

 By Jeffrey Jones at Gallup

For the third year in a row, the percentage of Americans naming inflation or the high cost of living as the most important financial problem facing their family has reached a new high.

The 41% naming the issue this year is up slightly from 35% a year ago and 32% in 2022. Before 2022, the highest percentage mentioning inflation was 18% in 2008. Inflation has been named by less than 10% in most other readings since the question was first asked in 2005.

The latest results are from Gallup’s annual Economy and Personal Finance poll, conducted April 1-22.

Gallup has asked Americans at least annually since 2005 to name, without prompting, the top financial problem facing their family. Inflation has topped the list for the past three years. The cost of owning or renting a home ranks second this year at 14%, a new high for that issue.

Other significant problems Americans identify include having too much debt (8%), healthcare costs (7%), lack of money or low wages (7%), and energy costs or gas prices (6%).

Over the past 19 years, healthcare costs and lack of money or low wages have frequently ranked near the top of the list, while the cost of energy or gas has done so at times of elevated gas prices, as in 2005, 2006 and 2008.

Inflation Named Most Often by All Subgroups

Inflation is named the most important financial problem by all key societal subgroups but garners higher mentions from certain age, income and political groups.

  • 46% of older Americans (those aged 50 and older) mention inflation, in contrast with 36% of younger Americans (those under 50).
  • Inflation is a more top-of-mind concern for middle-income (46%) and upper-income Americans (41% of those with an annual household income of $100,000 or more) than for lower-income Americans (31% of those with a household income of less than $40,000).
  • 56% of Republicans, compared with 39% of independents and 26% of Democrats, name the issue as the most important financial problem facing their family.

Younger and lower-income Americans may be less likely to name inflation than their counterparts because other immediate financial concerns are more pressing for them. For example, 21% of adults under age 50 say housing or rental costs are their top concern, compared with 8% of those aged 50 and older.

Lower-income Americans are more inclined than upper-income and middle-income Americans to say personal debt, healthcare costs, lack of money and job loss are the top concerns facing their family.

Retirement, Medical Emergencies Also Worrisome

A separate question in the survey asks Americans to say how much they worry about each of eight specific personal financial matters. Inflation is not one of those issues, but its influence is apparent in the heightened percentage who worry about not being able to maintain their standard of living. Fifty-five percent are very or moderately worried about maintaining their living standards, the third straight year a majority has done so after being below that level from 2017 through 2021.

Since the question was first asked in 2001, an average of 47% of U.S. adults, including a high of 58% in 2011, have worried about being able to maintain their standard of living.

Maintaining one’s standard of living ranks as one of the three economic matters Americans worry most about, along with not having enough for retirement and being unable to pay medical bills in the event of a serious illness or accident. The latter two issues have consistently ranked first or second each year in Gallup polling dating back to 2001.

Less than half of U.S. adults worry about the five other financial matters, including normal medical costs, normal monthly bills, housing costs, paying for their children’s college and making minimum payments on credit cards.

Compared with last year, there have been slight declines in the percentages worried about medical costs for a serious illness or accident (from 60% to 56%) and not having enough money for retirement (from 66% to 59%). Both issues are now closer to their historical averages after being slightly above them last year. For the other six financial matters, the percentages worried about them are essentially unchanged from a year ago.

As would be expected, those with a lower household income worry more than those with greater resources about nearly all of these financial matters. The one exception is affording college for a child, which shows no meaningful differences by income. Across the eight financial matters, an average of 60% of lower-income Americans express worry, compared with 47% of middle-income and 31% of upper-income Americans.

Majorities of lower-income adults worry about six of the eight financial matters, compared with three issues for middle-income adults and only one for those in upper-income households.

The greatest disparity in worry on any single issue between income groups is being able to pay one’s normal monthly bills, which concerns 67% of lower-income adults but only 21% of upper-income adults.

Ratings of Personal Finances Remain Subdued

Forty-six percent of Americans rate their personal finances as excellent or good, similar to what Gallup has measured the past two years but a worse evaluation than in 2017 through 2021. Meanwhile, 36% describe their finances as “only fair,” while 17% rate them as “poor.”

Americans’ ratings of their personal financial situation were worse than now between 2009 and 2012, as the U.S. was coming out of the Great Recession and unemployment was high. During those years, an average of 42% of Americans rated their personal finances positively.

All income groups remain less positive about their financial situation now compared with 2021. Currently, 72% of upper-income, 42% of middle-income and 25% of lower-income Americans rate their situation as excellent or good.

Another question in the survey finds 62% of Americans saying they have enough money to live comfortably, similar to the 64% recorded last year but down from 2022 (67%) and 2021 (72%). Gallup has only had one lower reading on this question since 2002 -- 60% in 2012. The high point was 75% in 2002, the first year the question was asked.

Eighty-three percent of upper-income, 62% of middle-income and 37% of lower-income adults say they have enough to live comfortably, with similar declines in each group since 2021.

Americans Slightly More Optimistic Their Financial Situation Is Improving

There has been a slight increase in the percentage of Americans who say their financial situation is getting better -- 43% say this, up from 37% in both 2022 and 2023. The current figure is still significantly below the 52% measured in 2021.

At the same time, 47% say their financial situation is getting worse, up by 17 percentage points since 2021.

A slim majority of upper-income Americans, 52%, believe their financial situation is improving, as do 43% of middle-income and 34% of lower-income Americans.

Bottom Line

Inflation continues to be an issue for Americans and is likely why less than half are positive about their financial situation. In addition to being named the most important financial problem facing their family, inflation also ranks as one of the domestic problems Americans worry most about. The issue trails only immigration, the government and the economy in general when Americans are asked to name the most important problem facing the country.

The U.S. inflation rate has declined significantly since its peak in 2022, but that has done little to alter Americans’ perceptions of their finances. This could reflect the cumulative effect of higher prices for the past few years and the fact that inflation has remained above the lower rates in the U.S. between 2012 and 2020. The latest government reports suggest inflation may be increasing again. That news persuaded the Federal Reserve to delay interest rate cuts it was expected to make this year.

The issue also stands to be a key election issue, and renewed inflation would hamper President Joe Biden’s chances of reelection.

https://www.zerohedge.com/economics/americans-continue-name-inflation-top-financial-problem-gallup