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Friday, May 3, 2024

Proton Pump Inhibitors Tied to Migraine, Other Severe Headache Types

 Proton pump inhibitors (PPIs), which are used to control acid reflux, are associated with an increased risk for migraine and other severe headache types, new research showed. 

Using data from the National Health and Nutrition Examination Survey (NHANES) investigators conducted a cross-sectional analysis and found all types of acid-suppression therapy were associated with an increased risk for severe headache including migraine but that PPI's conferred the greatest risk.

"It's important to note that many people do need acid-reducing medications to manage acid reflux or other conditions, and people with migraine or severe headache who are taking these drugs or supplements should talk with their doctors about whether they should continue," lead author Margaret Slavin, PhD, of the University of Maryland in College Park, said in a press release

The findings were published online April 24, 2024, in Neurology Clinical Practice

New Look at Old Data

Previous research has shown that headache is listed among the most common adverse reactions in adults taking PPIs and histamine receptor agonists (H2RAs), which include cimetidinefamotidine, and nizatidine

Other large studies of health databases have shown increased headache risk within a week of PPI exposure.

To compare the risk from PPIs vs H2RAs and other generic researchers analyzed data from the NHANES for those who used PPIs, H2RAs, and generic antacids to learn more about the potential link between acid-suppression therapy and headache.

They used survey data from 1999 to 2004, the only years the NHANES included a question about migraine and other headache during the past 3 months. 

Investigators analyzed data for 11,800 participants aged ≥ 20 years who used prescription drugs, over-the-counter medications, and nutritional supplements during the past month. 

Diet, BMI, Alcohol, Caffeine

Participants who used acid-suppressing medications had an increased risk for migraine or severe headache vs those who did not use these agents. Investigators found PPIs were tied to a 70% increased risk, while H2RAs and antacids were associated with 40% and 30% higher risks, respectively. Use of any type of acid-suppression therapy was tied to a 47% increased risk for severe headache.

Magnesium a Risk Factor?

While magnesium supplements are sometimes prescribed as a "natural" headache prevention therapy to prevent migraine and other headache types, the investigators noted they were surprised to find individuals taking H2RAs who met the dietary reference intake for magnesium had a nearly threefold increased risk for migraine or severe headache (odds ratio, 2.80; 95% CI, 1.02-1.45; = .025).

However, there was no association between magnesium and the other acid-reducing medications. 

The study's limitations included the use of a single question to identify migraine or severe headache, which may have resulted in some misclassification of the outcome. The authors also pointed out that dietary and drug-intake data may be subject to recall bias. 

"These results suggest that there is a need for more intentionally designed prospective

work to inform the extent to which associations between migraine and acid-suppression therapy are merely detecting comorbidities or to what extent migraine is an adverse event associated with the medications," the authors wrote. 

There was no targeted funding. Disclosures are noted in the original article. 

https://www.medscape.com/viewarticle/proton-pump-inhibitors-tied-migraine-other-severe-headache-2024a10008lz

Saving Hamas

 Reports are circulating that the Israelis are planning an operation in Rafah to eliminate the last Hamas stronghold in Gaza. If so, the Netanyahu government will be acting against the very public wishes of the Biden administration, which has spent the last half year moving heaven and earth to save a terrorist organization from destruction. Bizarrely, the White House’s statements and actions show that Hamas’ survival is more important than the security of a traditional American partner, Israel; more crucial to American interests than the preservation of the U.S.-led order of the Middle East; more precious than the dozens of American lives that Hamas ended on Oct. 7; more valuable than however many Americans and Israelis are still alive in the terror army’s tunnels.

Why? As the money and prestige that the U.S. has invested month after month in protecting Hamas demonstrate, the Biden administration sees the terror group as a valuable asset.

A day after the massacre, before Israel’s campaign against Hamas even began, Secretary of State Antony Blinken wrote that he was encouraging the Turkish government’s “advocacy for a cease-fire.” It makes no difference that the tweet has since been deleted, since the White House has produced no shortage of evidence since that its top priority is to deter Israel from defeating Hamas, by increasing Israel’s vulnerabilities at every turn, and conditioning aid on Israel adopting a purely defensive posture.

The Biden administration has stopped Israel from entering Rafah by demanding it produce plans to protect the civilian population, piously insisting that “even one civilian death is too many.” That would be a hard task in any military scenario, but given that Hamas hides among noncombatants, the White House’s policy openly reinforces the terror group’s political and military strategy.

The president abdicated America’s historical role of vetoing anti-Israel activity at the U.N. Instead, the U.S. delegation abstained from a key Security Council resolution in March demanding an immediate cease-fire—thereby putting America’s diplomatic weight behind Hamas’ demand that it should be allowed to keep its hostages and continue ruling Gaza. The White House then sanctioned Israeli civilians on the West Bank for crimes dreamed up by left-wing pro-Palestinian organizations, while ignoring a Palestinian terror wave aimed at murdering Jewish civilians who were guilty of crimes like stopping at a red light, buying gas, and herding sheep. Much of the false reporting supporting the pro-Hamas offensive is channeled through U.S. Army Gen. Michael Fenzel. The U.S. Security Coordinator for Israel and the Palestinian Authority are spending taxpayer resources to build a Palestinian terror army on the West Bank that may soon be repurposed for Gaza, too.

By compelling Jerusalem to “surge” food aid and energy to Gaza, the White House broke Israel’s siege, and demanded an ally resupply its adversary at wartime. Whenever Israel goes on the offensive, Biden and aides publicly threaten to stop resupplying arms. After Iran’s massive missile and drone attack last month, administration officials let on that if Israeli retaliatory strikes exceeded meager U.S. limits, the White House would hobble Israel’s air defense systems. Thus, the Israelis were forced to adopt the battle-tested American military strategy of bombing sand.

The White House has used CIA Director William Burns as one of its main instruments of diplomatic deterrence. He’s traveled to Egypt, Qatar, and elsewhere for endless hostage negotiations with the Palestinian terrorist organization. That none of these negotiations has gone anywhere is the point. Burns’ jawboning is designed to stall Israel’s war while legitimizing the act of hostage-taking, even as it’s become increasingly clear that many of the hostages whose release he is supposedly negotiating for are dead.

To emphasize its evenhandedness in the conflict between a key U.S. military ally and a designated foreign terrorist organization, the White House has amplified Hamas propaganda that has repeatedly been shown to be false. The president himself and the secretary of state enthusiastically repeated accusations that Israel intentionally murdered World Central Kitchen aid workers. Without evidence to support USAID head Samantha Power’s claims of rampant famine in Gaza, the administration and its validators began calling it a “reported famine.”

To fight the mythical famine, Biden is sending thousands of U.S. troops to build a $320 million pier to resupply Hamas—an arrangement that will turn American forces into human shields to deter Israeli military operations against the terror organization. By leaking fake news, most recently an internal State Department memo alleging Israeli war crimes, that Israel was hindering aid to starve Gazans, the administration laid the groundwork for arrest warrants likely to be issued by the International Criminal Court. While the warrants reportedly target Netanyahu and other members of Israel’s war cabinet, the action is likely to set a precedent broad enough to justify arresting any Israeli who served in the Gaza campaign.

It’s useful to remember that what distinguishes the Palestinians from other ethno-national groups born of the breakup of the multiethnic empires of Europe and the Levant after World War I is that their claim on the world’s attention issues largely from their willingness to hire themselves out as terrorist mercenaries.

During the Cold War, the Palestinians were used by the Soviets against the U.S. and American interests and allies. Regional powers like Nasser’s Egypt, Assad’s Syria, Saddam’s Iraq, and Ghaddafi’s Libya used the Palestinians to advance their own interests, against the superpowers and/or each other. Not infrequently, Palestinian factions fought each other on behalf of their Arab patrons.

It was through this nonstop violence that the Palestinian cause flourished. The Palestinians won a place in regional and then international forums not because of a world-historical injustice done to an ad hoc confederacy of minor Levantine bloodlines. Rather, it was because if you didn’t employ a mercenary gang of Palestinians against your enemies, you would be exposed to a terror campaign waged by a rival band of Palestinians, sponsored by your rivals.

What Middle East watchers call the “Palestinian veto” refers to the ability of Palestinian terrorists to destabilize any given regional order that doesn’t suit the ambitions of whoever their dominant patron happens to be. For instance, the 1979 Israel-Egypt peace treaty came about only because Egyptian President Anwar Sadat insisted on keeping the Palestinians out. Unlike Jimmy Carter, Sadat didn’t care about a comprehensive peace in the Holy Land with the Palestinians front and center—he knew that giving the Palestinians a seat would give the Soviets and their Arab allies an opening to derail an agreement he needed to advance Egyptian interests.

On whose behalf were the Palestinians acting when they destabilized the region with their gruesome Oct. 7 attack? Iran—but also the Biden administration. The two share an interest in collapsing the traditional U.S.-led order of the Middle East that Donald Trump had restored, after Barack Obama began the process of dismantling it.

Up until Obama, the pillars of America’s security architecture were the Persian Gulf’s oil-rich Arab states, led by Saudi Arabia, and, in the eastern Mediterranean, Israel and Egypt. Early in his first term Obama signaled he intended to undo that order when he gave a speech in Cairo and invited officials from the Muslim Brotherhood, existential enemies of the military regime then led by Hosni Mubarak. Within two years, the White House withdrew its support for Mubarak during the Arab Spring revolutions and ushered in a Muslim Brotherhood government. Egypt became the first pillar of the old U.S. security order to fall.

Obama’s aides made it clear that his second term would be devoted to securing a nuclear deal with Iran. The purpose of the deal, officially known as the Joint Comprehensive Plan of Action (JCPOA), was not to prevent an Iranian bomb—in fact, the agreement legalizes the clerical regime’s nuclear weapons program. Rather it was to realign U.S. interests with Tehran while stiffing traditional U.S. partners, especially Riyadh and Jerusalem, the other regional pillars of the American order. To cap off his eight years of dismantling the instruments of U.S. policy in the Middle East, Obama’s final foreign affairs initiative was to push a U.N. Security Council resolution adopting the Palestinian position that Israel was in violation of international law by occupying, among other places, historic Jewish holy sites.

Then came Donald Trump, who not only reversed Obama’s realignment but reinforced Washington’s traditional security architecture. Trump’s first official trip was to Saudi Arabia. He explained that the U.S.-Saudi alliance was good for the U.S. because it meant affordable oil, investment in America, and American jobs. Trump defended the Saudis when retired U.S. spies, The Washington Post, Obama operatives, and foreign intelligence services joined in an information operation to isolate Crown Prince Mohammed bin Salman after the murder of former Saudi intelligence official Jamal Khashoggi.

That was only the beginning, as step by step Trump erased Obama’s legacy in the Middle East, and restored the pillars of the American-led regional security order. He backed the military regime in Cairo, and moved the U.S. Embassy in Israel to Jerusalem. He acknowledged Israeli sovereignty over the Golan Heights, the Jordan Valley, and large parts of the West Bank. The Trump-brokered normalization agreements between Israel and other regional states, known as the Abraham Accords, reaffirmed the U.S.-led regional order by binding our allies to each other—and thus to America.

Crucially, the Abraham Accords also ignored the Palestinians. After all, the Palestinians could never normalize relations without forfeiting their ability to project power and demand tribute. Like Sadat, Trump and his diplomats understood that peace could only be made by sidelining the Palestinians and whoever was sponsoring them, in this case Iran.

Naturally, the Abraham Accords were repugnant to the Obama faction. The normalization deals undid Obama’s balance of power project—i.e., strengthen U.S. adversaries at the expense of allies—and pushed the left’s longtime darlings, the Palestinians and the Islamic Republic to the margins. Accordingly, the Biden administration unfroze money to fill Iran’s war chest and undermined regional normalization under cover of expanding it to Saudi Arabia. Any direct talks between Israel and Saudi, the steward of Islam’s holy shrines, would, if only for the sake of protocol, have to involve the Palestinian cause. Thus, the Biden administration put the Palestinians at the center of the region again.

That’s how we got to Oct. 7. Contrary to the Biden administration’s talking points, the Iranians didn’t see Saudi-Israeli normalization talks as an existential threat; rather, they correctly saw it, and other Biden moves, as an invitation to disrupt and destabilize the regional order that Trump had rebuilt. Subsequently, in traditional regional fashion, the Iranians mobilized their Palestinian proxy.

And yet for many good-faith observers, it remains a mystery why Obama and then Biden sought to undo the U.S. order of the Middle East, an arrangement that has kept a volatile and strategically vital region relatively stable. Is it ego alone that requires Obama and his party must be proven right, and that Trump’s successes must be transformed into failures at America’s expense—and at the additional price of destroying the prospects of a relatively hopeful future for Middle Easterners?

The key fact is this: The regional order that Trump restored has long been part of the formula that ensures continued U.S. domestic peace and prosperity. To put it another way, the moves made by Obama and now Biden are not primarily about destabilizing the Middle East. Rather, they are designed to destabilize the United States.

The Biden team’s moves to shelter Hamas are best understood in the context of a revolutionary program of domestic initiatives that aim to reconstitute American society on a new basis, and which in turn require the outright rejection of the country’s history and culture, its existing social arrangements, and constitutional order. The current regime has weaponized the security state, labeled its opponents “domestic terrorists,” and waged a third-world-style campaign against the opposition candidate because it’s a revisionist faction. Its political and cultural manifesto is a program for remaking America, whether through social pressure, or censorship, or bureaucratic fiat, or threats of violence, or actual violence. Among other devices to transform America, the Biden administration has opened the border to at least 7 million illegal aliens (and counting), many from places in the Middle East where Hamas is revered, and for whom political violence means steady, well-paid work.

It’s not the traditional U.S.-led order in the Middle East that the revisionist faction, Obama’s faction, is most determined to dismantle but rather the existing order in the U.S. And it’s not Israel that it’s most keen to grind into dust, but America. For the party that Obama remade in his image to triumph at home, the Palestinians must win.

Lee Smith is the author of The Permanent Coup: How Enemies Foreign and Domestic Targeted the American President (2020).

https://www.tabletmag.com/sections/news/articles/saving-hamas

TD worst-case scenario more likely after drug money laundering allegations: analyst

 TD Bank Group could be hit with more severe penalties than previously expected, says a banking analyst, after a report that the investigation it faces in the U.S. is tied to laundering illicit fentanyl profits.

National Bank analyst Gabriel Dechaine said in a note that the worst-case scenario of the multiple U.S. investigations TD faces needs reassessing after the Wall Street Journal reported the link on Thursday.

The newspaper said the U.S. Justice Department investigation is focused on how Chinese drug traffickers allegedly used TD to launder at least US$653 million, and bribed TD employees to do so.

TD did not directly confirm the report, but said its anti-money laundering defences had been deficient.

"Criminals relentlessly target financial institutions to launder money and TD has a responsibility and an obligation to thwart their illegal activity," said chief executive Bharat Masrani in a late Friday statement.

"I regret that there were serious instances where the bank's AML program fell short and did not effectively monitor, detect, report or respond. This is unacceptable and not in line with our values."

The bank said a comprehensive overhaul of its program is well underway, with over $500 million already spent in program remediation and platform enhancements.

The severity of the allegations means TD could not only face fines well above the $500 million to $1 billion that many investors have anticipated, but also more severe regulator-imposed limitations on its business activities, said Dechaine.

"We believe investors need to put greater weight on worst-case scenarios for the stock," he said in a note.

The cumulative fines could easily hit $2 billion, while regulators could put in place restrictions, including limits on its balance sheet growth, that could affect bank operations for years, said Dechaine.

In a worst-case scenario, the issue could erode TD's future earnings potential by more than $1 billion, he said, and he has dropped his price target for the bank's TSX-listed shares by almost nine per cent to $84.

The link to drug trafficking comes the same week TD announced it had taken an initial provision of US$450 million in connection to the ongoing U.S. regulatory inquiry into its anti-money laundering compliance program.

The bank said on Tuesday its discussions with three U.S. regulators and the Department of Justice are ongoing, and it anticipates additional financial penalties.

Separately, Canada’s financial-crime watchdog Fintrac levied a $9.2-million penalty against the bank on Thursday for non-compliance with money laundering and terrorist financing measures.

TD Bank's stock price fell almost six per cent to $74.80 Friday on the Toronto Stock Exchange.

https://ca.finance.yahoo.com/news/td-penalties-expected-higher-alleged-151810058.html

College Fraternities Rise Up Against Marxist Protesters Chanting For 'Socialist Takeover Of America'

 Colleges and universities are witnessing a coordinated push to spark a new movement resembling Black Lives Matter ahead of the summer months. This time, it's under the guise of defending Palestine while embedding Marxist ideologies, such as quite literally calling for a 'revolution' to usher in 'a socialist reconstruction of the USA.' 

Once again, George Soros and his Open Society Foundation are funding Marxist chaos across campuses, with Soros-funded Students for Justice in Palestine (SJP) having organized them. These professional agitators are trained to rise up for revolution. 


So, not enough college students? These radical groups had to import 'outsiders'. 

Recall that the son of pro-chaos billionaire Soros, Alex, visited the White House over a dozen times for meetings since 2021. 

Meanwhile, Axios reports Democrats are in full-blown 'panic mode' behind the scenes as campus takeovers by extremists of their own party produce terrible optics ahead of the presidential election in November. 

"The longer they continue, and the worse that they get, the worse it's going to be for the election overall," one House Democrat said.

The House Democrat warned that school chaos will only "bring out [the public's] most conservative side." 

What's clear is that campus protesters are becoming a political liability for Biden and Democrats. That's because Americans aren't falling this time for the fake BLM-style protests. Many folks are realizing just how artificial these protests have become. 

One X user asked: "Is it  about Free Palestine? or Attack on Capitalism?" 

They outlined the four main goals of Marxists stoking campus chaos: 

  1.  Gain Power
  2. Destabilize the System
  3. ATTACK CAPITALISM!
  4. Usher in their Marxist Utopia

X user Western Lensman might want to update his list... 

Let's remind readers that right before the campus uprisings, there was a surge in Maxists, masquerading as pro-Palestinian protesters, attempting to shut down the nation's critical infrastructure, including bridges, highways, and airport terminals. We asked at the time, "Who are these pro-Palestinian protesters? And who are they being funded by?" 

Shutting down critical infrastructure and causing chaos on campuses has nothing to do with helping poor Palestinians, just like burning down businesses and police stations during the Black Lives Matter riots had nothing to do with helping working poor blacks. These movements are hijacked by Marxists, with one intention only: crash the US economy and abolish capitalism.

Besides Soros, could it also be the Saudis, Qataris, and dark Middle Eastern monies that plowed money into Ivy League schools to prop up radical leftists with one common goal? That goal could be to destroy America from within. 

After all, America's enemies don't even need to fire a shot when woke Harvard University staff can allow the film screening of "How to Blow Up A Pipeline" to students. 

 The Marxist takeover of America is happening through colleges that have become indoctrination camps for the youth. 

Yet the FBI, CIA, and other intelligence agencies are turning a blind eye to this chaos. They're more focused on going after President Biden's political opponents. 

However, out of all this chaos this week, there was a glimmer of hope as fraternities at universities stood up to protect Old Glory. 

The most notable were the boys at Pi Kappa Phi at UNC - who protected Old Glory from protesters. The boys turned around and raised $500,000 on GoFundMe to throw an epic rager for their heroic patriotic duties. 

Frats across the nation got the memo...

They, too, must defend against Marxism.

Let’s see what the frat boys can do at the southern border.

https://www.zerohedge.com/political/college-fraternities-rise-against-marxist-protesters-chanting-socialist-takeover-america