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Friday, September 13, 2024

Ascendis First Results from Platinum-Resistant Ovarian Cancer (PROC) Cohort Phase 1/2

 

  • Anti-tumor clinical responses were observed in 29% (4/14) of efficacy-evaluable patients with PROC treated with TransCon IL-2 β/γ in combination with chemotherapy
  • Initial data suggest clinical activity in heavily pre-treated PROC patients and that TransCon IL-2 β/γ in combination with chemotherapy was generally well-tolerated

Moderna cut to Sell by JP Morgan

 The analyst of JP Morgan, Jessica Fye, reviews opinion on the case. The broker switches to sell against neutral beforehand. The target price is decreased from USD 88 to USD 70.

https://www.marketscreener.com/quote/stock/MODERNA-INC-47437573/news/MODERNA-JP-Morgan-lowers-to-Sell-rating-47867095/

Meta to start using public posts on Facebook, Instagram in UK to train AI

 Meta Platforms will begin training its AI models using public content shared by adults on Facebook and Instagram in the UK over the coming months, the company said, after it had paused the training in the region following a regulatory backlash.

The company will use public posts including photos, captions and comments to train its generative artificial intelligence models, it said on Friday, adding that the training content will not include private messages or information from accounts of users under the age of 18.

The update follows Meta's decision in mid-June to pause the launch of its AI models in Europe after the Irish privacy regulator told the company to delay its plan to harness data from social media posts.

The company had then said the delay would also allow it to address requests from Britain's Information Commissioner's Office (ICO).

"Since we paused training our generative AI models in the UK to address regulatory feedback, we've engaged positively with the ICO ... this clarity and certainty will help us bring AI at Meta products to the UK much sooner," Meta said on Friday.

Facebook and Instagram users in the UK will start receiving in-app notifications from next week explaining the company's procedure and how users can object to their data being used for the training, Meta added.

In June, the company's plans faced backlash from advocacy group NOYB, which urged national privacy watchdogs across Europe to stop such use of social media content, saying the notifications were insufficient to meet EU's stringent EU privacy and transparency rules.

https://www.marketscreener.com/quote/stock/META-PLATFORMS-INC-10547141/news/Meta-to-start-using-public-posts-on-Facebook-Instagram-in-UK-to-train-AI-47868661/

United Airlines taps Elon Musk's Starlink for in-flight internet

 United Airlines said on Friday it has signed a new deal with Elon Musk's Starlink for in-flight internet services.

Starlink, a unit of SpaceX, has inked deals with multiple airlines to provide in-flight internet services as it seeks to expand its reach beyond consumers and households in rural areas around the world with little to no internet access.

The satellite-based internet services provider has previously signed deals with Hawaiian Airlines and regional carrier JSX.

United expects to have Starlink's internet connectivity in all its more than 1,000 aircraft over the next several years.

Testing for the service will begin in early 2025, with the first passenger flights anticipated later that year.

The carrier also revealed its plans to keep Starlink's services on its flights free.

https://www.marketscreener.com/business-leaders/ELON-MUSK-1364/news/United-Airlines-taps-Elon-Musk-s-Starlink-for-in-flight-internet-47867481/

Kiniksa started at Buy by Jefferies

 Target $40

https://finviz.com/quote.ashx?t=KNSA&p=d

Well Fargo's new regulatory trouble may delay asset cap removal timeline

 Wells Fargo's latest regulatory setback could delay the timeline for lifting the asset cap imposed by the U.S. Federal Reserve and stifle its growth, Wall Street analysts said on Friday.

Its ability to expand into risky businesses was restricted on Thursday by a U.S. banking regulator that found the California-based lender had weak safeguards against money laundering and other illegal transactions.

Though the Office of the Comptroller of the Currency (OCC) did not fine the bank as it was working to fix the problems, analysts said the action could hurt its effort to tackle regulatory issues stemming from the 2016 fake accounts scandal.

"Although an enforcement action against a bank for AML (anti-money laundering) policies and procedures is unfortunately not that uncommon, it is unique for WFC as it adds uncertainties to the timeline of the asset cap and their expense outlook," KBW analysts, led by David Konrad, said in a note.

Wells Fargo is operating under a $1.95 trillion asset cap until regulators are satisfied that the bank has fixed its issues.

The 2016 fake accounts scandal led to heightened scrutiny, billions of dollars in penalties, and multiple shareholder lawsuits against the bank, with regulators mandating more oversight of the lender.

The bank is operating under eight consent orders - a formal public enforcement action between a regulator and a bank that often includes a fine and requires the bank to address specific issues in a timely manner.

CEO Charlie Scharf has been working to contain the fallout and help resolve the consent orders since he took the top job in 2019.

Wells Fargo had said in February the OCC had ended a 2016 punishment for the bank's sales practices, after it spent years trying to repair the damage from the fake accounts scandal.

The move could pave the way for the Fed to lift its consent order, analysts had at the time said.

"An unfortunate but not shocking step back in what had otherwise been good forward progress this year on resolving regulatory concerns," Piper Sandler analysts said.

Russia produces kamikaze drone with Chinese engine

 Russia started producing a new long-range attack drone called the Garpiya-A1 last year using Chinese engines and parts, which it has deployed in the war in Ukraine, according to two sources from a European intelligence agency and documents seen by Reuters.

The intelligence – which included a production contract for the new drone, company correspondence on the manufacturing process and financial documents - indicated that IEMZ Kupol, a subsidiary of Russian state-owned weapons maker Almaz-Antey, produced more than 2,500 Garpiyas from July 2023 to July 2024.

The existence of the new Russian drone incorporating Chinese technology has not been previously reported. IEMZ Kupol and Almaz-Antey did not respond to requests for comment.

The two intelligence sources said that the Garpiya, which means Harpy in Russian, has been deployed against military and civilian targets in Ukraine, causing damage to critical infrastructure as well as both civilian and military casualties.

They shared with Reuters what they said were images from Ukraine of the wreckage of a Garpiya, without providing further details. Reuters found information that reinforces this conclusion, but was unable to confirm the images independently.

The sources asked that neither they nor their agency be identified due to the sensitivity of the information. They also asked that certain details, such as dates, related to the documents be withheld.

Samuel Bendett, an adjunct senior fellow at the Center for a New American Security, a Washington DC-based think tank, told Reuters that Garpiya, if confirmed, would mark a departure from Russia's reliance on Iranian designs for long-range drones.

"If this is happening, it could indicate that Russia can now rely more on domestic development as well as, obviously, on China, since both sides in this war depend on many Chinese components for drone production," he said.

Iran, which didn't comment for this story, has supplied more than a thousand Shahed "kamikaze" drones to Russia since the start of the invasion in February 2022, Ukrainian President Volodymyr Zelenskiy said in May last year.

They have been used to exhaust Ukrainian air defences and hit infrastructure far from the front lines. Iran has repeatedly denied sending drones to Russia for use in Ukraine.

Russia's defence ministry did not respond to a request for comment for this story. The Chinese foreign ministry said in a statement to Reuters that Beijing strictly controls the export of items with potential military applications, including drones.

"With regard to the Ukrainian crisis, China has always been committed to promoting peace talks and political settlement," the statement said. It added that there were no international restrictions on China's trade with Russia.

NATO APPEAL

NATO Secretary General Jens Stoltenberg last week called on China to stop supporting Russia's war in Ukraine and said Beijing's assistance has been a significant factor in the continuation of the conflict.

The Garpiya "closely resembles the Shahed" but it has several distinguishing features, including a unique bolt-on fin and Limbach L-550 E engines, the European agency said in a statement to Reuters. The engine, which was originally designed and manufactured by a German company, is now produced in China by a local firm, Xiamen Limbach. The company did not respond to a request for comment.

Reuters reviewed a contract worth more than 1 billion rubles (10 million euros) signed in the first quarter of 2023 between the Russian defence ministry and Kupol for the development of a factory to produce the drones.

The intelligence sources said a former cement factory situated in Izhevsk, Udmurt Republic, in western Russia – which was purchased by Kupol in 2020 - is being used to produce the drones.

Using a video of a Russian drone production facility posted on the Telegram messaging app, Reuters was able to identify the site as the factory in Izhevsk from the colour and design of the building's beams and internal architecture which matched file imagery of the site. The location of the file imagery was verifiable from nearby buildings, roads, and trees that matched street views and satellite imagery.

A prototype of the Garpiya was launched in the first half of 2023, company communications showed. Production reached several hundred in the second half of 2023 and more than doubled to around 2,000 in the first half of 2024, the agency said.

Bendett, the defence analyst, said 2,500 drones per year would represent a sizeable chunk of Russia's output. Ukraine's top military commander, Oleksandr Syrskyi, said last month that Russia has fired nearly 14,000 strike drones since it invaded in February 2022, including the Iranian Shahed as well as the Russian-made Geran-2 and Lancet drones.

Corporate documents dated from the second quarter of 2023, reviewed by Reuters, showed that supplier TSK Vektor procured parts from Chinese companies for assembly at the Kupol site; 800 Chinese engines were also to be delivered to the new plant where the production line was due to ready by end of the quarter.

TSK Vektor did not respond to request for comment.

The European intelligence service said in the statement it was concerned that Chinese companies were continuing to provide components that enabled Russian production of large kamikaze drones. "The export of the essential components to Russia needs to stop," it said.

UNITED STATES VOICES CONCERN

Washington has repeatedly warned Beijing over its support for Russia's defence industry. It has imposed hundreds of sanctions aimed at curbing Moscow's ability to exploit certain technologies for military purposes. The State Department and the White House did not respond to a request for comment for this story.

In July, China said it would tighten drone export rules starting on Sept. 1. Beijing has said U.S. sanctions on Chinese entities over the Ukraine war are "illegal and unilateral".

The Garpiya has a take-off weight of less than 300 kilos and a maximum range of 1,500 kilometres, the production contract between Kupol and the Russian defense ministry said – roughly similar to Iran’s Shahed-136 drones that Moscow has used extensively in Ukraine.

The Washington Post reported in August that Russia aimed to increase production of a domestic version of the Shahed-136, known as the Geran-2, at a plant in the Alabuga Special Economic Zone, in Tatarstan. Ukraine said in April it had carried out a drone strike against a drone manufacturing plant at Alabuga.

A third document reviewed by Reuters - a delivery status update between the intermediary TSK Vektor and the manufacturer Kupol, dated in the first quarter of 2024 - detailed an order for 100 axles, carburettors and other Limbach engine parts supplied by two other Chinese companies: Juhang Aviation Technology and Redlepus Vector Industries, both based in Shenzhen.

Juhang, which was placed under British sanctions in February and U.S. sanctions in May for providing Russia with drone equipment, and Redlepus did not respond to requests for comment.

Customs data, obtained from a commercial supplier that records and compiles the information, showed that from April 2022 to December 2023, TSK Vektor imported $36.3 million in goods from Chinese Juhang Aviation Technology, and $6.2 million from Redlepus TSK Vector Industrial Shenzhen Co Ltd.

According to the customs documents, the goods included aircraft engines, transistors, electronic modules, connectors, plugs and sockets, spare parts and components most of them marked as "for general civil purpose", "for general industrial purpose", "for general civil use".

https://www.yahoo.com/news/exclusive-russia-produces-kamikaze-drone-101314697.html