Search This Blog

Tuesday, June 24, 2025

'USPSTF Urges Screening for Intimate Partner Violence, still not enough evidence on elder abuse screening'

 

  • Updated USPSTF recommendations say intimate partner violence (IPV) screening has moderate benefit but there isn't enough research on elder abuse screening.
  • These recommendations do not reflect a change from the last USPSTF recommendations in 2018.
  • One new aspect, though, is that older and vulnerable adult abuse screening recommendations are now framed around caregiver abuse and neglect.

The U.S. Preventive Services Task Force (USPSTF) renewed its recommendation for intimate partner violence (IPV) screening and its call for more evidence on screening for abuse of older or vulnerable adults.

In line with 2018 guidanceopens in a new tab or window, the task force recommended that adolescents and adults who are pregnant or postpartum and all women of reproductive age should be screened for intimate partner or domestic abuse.

"The USPSTF concludes with moderate certainty that screening for IPV in women of reproductive age, including those who are pregnant and postpartum, and providing or referring those who screen positive to multicomponent interventions with ongoing support has a moderate net benefit," the group led by Michael Silverstein, MD, MPH, of Brown University in Providence, Rhode Island, wrote in JAMAopens in a new tab or window.

The task force also reviewed evidence on screening for abuse of older or vulnerable adults with a physical or mental disability who haven't displayed recognized signs and symptoms of abuse or neglect.

In an evolution from 2018, the task force specified caregiver abuse, meaning when a trusted person or caregiver "causes or creates risk of harm to an older adult." This term was added "to clarify when the focus was on screening for abuse or neglect perpetrated by a caregiver or someone they trust," Silverstein wrote. Caregiver abuse includes physical, sexual, emotional, and psychological abuse, as well as neglect, abandonment, or financial exploitation. In fact, financial exploitation and neglect were found to be most common, the task force noted.

For this area, USPSTF reiterated its 2018 decision that current evidence is insufficient to assess the balance of benefits and harms.

None of the 35 studies included in the evidence review, also published in JAMAopens in a new tab or window, for the update evaluated screening or interventions for caregiver abuse among older or vulnerable adults; just two assessed the accuracy of caregiver abuse screening tools for this population, with mixed results.

Nearly half of adults report experiencing sexual or physical violence or stalking at some point in their lifetime, Silverstein and team noted. Women and people who report a gender different than sex experience higher levels of IPV than men. Additionally, 1 in 10 adults older than 60 report experiencing some form of abuse or neglect in the past year. Authors noted that these groups are not mutually exclusive.

Beyond screening checklists, something all clinicians should do as "an essential part of good healthcare" is to create safe environments for patients to disclose abuse, according to Eve Rittenberg, MD, MA, of Brigham and Women's Hospital and Harvard Medical School in Boston, and colleagues, writing in a linked editorial in JAMA Internal Medicineopens in a new tab or window.

One tactic is to meet with the patient alone without a caregiver, partner, or family member present so the patient can speak candidly. Physicians can ask if the patient feels safe in their environment and respond "with nonjudgmental empathy, validation, and support if they report concerns." Rittenberg's group also recommended connecting caregivers with resources and respite care to help combat stress.

"Clinicians and health systems should have protocols in place to respond to disclosures and connect the patient to appropriate resources for shared decision-making, safety planning, and follow-up," she concluded.

In another editorialopens in a new tab or window in JAMA, Melissa Simon, MD, MBA, MPH, of Northwestern University Feinberg School of Medicine in Chicago, wrote that the "IPV and elder abuse dual epidemics deserve more attention," calling them "public health emergencies, with survivors also facing profound consequences."

Simon called them "hidden epidemics" because of major data gaps, partially due to lack of standard definitions and measurements, and disciplinary silos.

"This stagnation in the development of more evidence-based interventions for IPV and elder abuse is troubling, especially in the setting of the current reductions in federal support for public health, healthcare delivery, and research," she wrote, adding that many organizations, including CDC, have had to pause or scale back support for IPV and elder abuse programs.

Simon also noted that federal bans on words like "diversity," "gender," and "women" may discourage researchers from studying these vital topics. Plus, abortion restrictions increase risk of reproductive coercion and "create a climate of fear that discourages both disclosure and data collection."

Ultimately, the revised USPSTF recommendation "is a stark reminder of how fragmented and incomplete current knowledge and ability to prevent IPV and elder abuse are," Simon wrote. "Defunding federal research agencies, eliminating independent review bodies, and eroding reproductive rights only deepen these gaps, leaving millions of U.S. residents vulnerable to preventable harm."

The evidence review spanned studies found in PubMed/MEDLINE, Embase, and the Cochrane Library from 2017 through Dec. 14, 2023, along with studies used in the prior USPSTF review. Eligible studies on screening test accuracy, randomized trials of screening or interventions, and cohort studies on potential harms were conducted in English, recruited in primary care and emergency department settings, and were conducted in countries marked "very high" on the Human Development Index.

For IPV, two randomized trials showed no harms of IPV screening compared to no screening, while one found no significant reduction in IPV nor benefit for other outcomes 3 to 18 months after screening. Among nine studies focused on the accuracy of detecting past-year or current IPV, sensitivity ranged from 26% to 87%, and specificity ranged from 80% to 97%.

Thirteen trials evaluated various interventions for women with screen-detected IPV. One found a significant reduction in IPV with multiple perinatal home visits (standardized mean difference −0.34, 95% CI −0.59 to −0.08). Another found significantly fewer recurrent episodes of IPV with behavioral counseling for multiple risks, including IPV, smoking, depression, and tobacco (standardized mean difference −0.40, 95% CI −0.68 to −0.12). Studies looking at brief counseling or advocacy interventions specific to IPV found no difference in overall IPV rates.

In terms of limitations of the new evidence, the review focused on populations without signs or symptoms of abuse and didn't evaluate clinician or patient preferences for screening implementation preferences. Studies relating to the accuracy of screening included some from emergency department settings, limiting applicability to primary care.

Disclosures

All authors followed the USPSTF policy regarding conflicts of interest, and all USPSTF members receive travel reimbursement and an honorarium for participation.

One author reported receiving grants from the National Institute on Aging.

Simon noted being a former member of USPSTF and participating in the 2018 recommendation statement for intimate partner violence and elder abuse.

Rittenberg reported receiving honoraria from Harvard Medical School and CME Outfitters for continuing medical education talks on intimate partner violence and trauma-informed care.

Other editorialists had no disclosures.

Primary Source

JAMA

Source Reference: opens in a new tab or windowSilverstein M, et al "Screening for intimate partner violence and caregiver abuse of older or vulnerable adults: U.S. Preventive Services Task Force Recommendation Statement" JAMA 2025; DOI: 10.1001/jama.2025.9009.

Secondary Source

JAMA

Source Reference: opens in a new tab or windowFeltner C, et al "Screening for intimate partner violence and for caregiver abuse of older or vulnerable adults: An evidence report and systematic review for the U.S. Preventive Services Task Force" JAMA 2025; DOI: 10.1001/jama.2025.2449.

Additional Source

JAMA

Source Reference: opens in a new tab or windowSimon MA "The evidence for intimate partner violence and elder abuse screening: Stagnation at a critical juncture" JAMA 2025; DOI: 10.1001/jama.2025.10085.

Additional Source

JAMA Internal Medicine

Source Reference:opens in a new tab or window Rittenberg E, et al “Updated USPSTF guidelines on screening for intimate partner violence and caregiver abuse” JAMA Intern Med 2025; DOI: 10.1001/jamainternmed.2025.3095.


https://www.medpagetoday.com/obgyn/domesticviolence/116212

Trump Signals Strategic Shift: China Can Buy Iranian Oil

 President Trump dropped a geopolitical bombshell: in a post on Truth?Social, he announced that "China can now continue to purchase Oil from Iran. Hopefully, they will be purchasing plenty from the US, also."

This declaration signals a notable pivot from the so-called "maximum pressure" campaign Trump reinstated in February?2025, which aimed to slash Iranian oil exports to near zero. Instead, Trump appears to be leveraging this concession to coax China into importing American energy—linking geopolitical maneuvers with trade incentives.

Coming on the heels of his announcement of a tentative Israel?Iran ceasefire, this move underlines Trump’s transactional diplomacy: brokering Middle East calm in exchange for strategic trade gains. While U.S. airstrikes targeted Iran’s nuclear facilities, Trump now extends clemency to China on its Iranian oil imports—a calculated reward for non-interference and trade cooperation.

Analysts stress this isn’t about oil prices—the real story lies in Trump’s attempt to transform U.S. diplomatic leverage into economic advantage. China, which silently eyed the ceasefire, refrained from harsh backlash and kept its vital Iranian oil lifeline intact. In return, Trump wants China to import more American oil—a potential win for U.S. producers and domestic energy policy.

It’s a high-stakes game: Washington loosens pressure on Iran to coax China away from Iranian energy, swap dependence for U.S. barrels, and reward restraint. But Beijing—aware of cheaper Iranian and Russian sources—may balk.

We’re witnessing a new fusion of military brinksmanship with economic brinkmanship. Trump’s message is clear: de-escalation gets rewarded, and oil becomes the currency. Whether Beijing takes the deal, and whether Tehran stays in line, remains to be seen.

https://oilprice.com/Energy/Crude-Oil/Trump-Signals-Strategic-Shift-China-Can-Buy-Iranian-Oil.html

FDA investigates patient deaths after treatment with Sarepta’s gene therapy

 The U.S. Food and Drug Administration said on Tuesday that it is investigating reports of two deaths due to acute liver failure in non-ambulatory Duchenne muscular dystrophy patients after receiving Sarepta Therapeutics (NASDAQ:SRPT)’ gene therapy, Elevidys.

In June, Sarepta reported a second death in a patient who had received its gene therapy, which raised concerns about the safety and future demand for the treatment.

The patients who died were a 16-year-old, weighing 70 kilograms, and a 15-year-old, weighing 50 kilograms. Both boys were non-ambulatory and their deaths occurred within 90 days after treatment, the company said in an investor call last week.

The two patients showed signs of acute liver failure and were hospitalized less than two months after treatment with Elevidys, the health regulator said on Tuesday. It added that it is evaluating the need for further regulatory action.

Sarepta said in an email to Reuters, "The FDA communication was triggered by our report to the FDA and our suggested update to the label to include information relating to the recent events." 

The U.S. prescribing information for Elevidys warns of acute liver injury but does not mention liver failure or death.

Elevidys, approved by the FDA in 2024 for ambulatory Duchenne muscular dystrophy patients aged four and older, is the only gene therapy available for the disease. It carries a known risk of liver damage and was conditionally approved for non-ambulatory patients despite failing to meet the main goal in a late-stage study.

Sarepta said earlier this month it was investigating both cases independently and in relation to each other to identify any common risk factors. 

The company has suspended its Elevidys sales forecast for 2025, halted shipments to non-ambulatory patients and is working with regulators on a new treatment plan.

https://www.investing.com/news/stock-market-news/fda-investigates-patient-deaths-after-treatment-with-sareptas-gene-therapy-4109252

What is 'Alligator Alcatraz'? Florida seizes Everglades land for immigrant detention center

 "Alligator Alcatraz" is happening.

Days after State Attorney James Uthmeier posted a video to X calling for a proposed immigrant detention facility at the site of the Dade-Collier Training and Transition Airport — a remote and little-used airstrip near the Everglades — Gov. Ron DeSantis' office announced the state would use emergency powers to take control of the land away from Miami-Dade County to create "Alligator Alcatraz."

Alligators and snakes would help prevent runaways, Uthmeier said.

The governor's office said in a statement that the Florida Division of Emergency Management offered to buy the land, but Miami-Dade County Mayor Daniella Levine Cava responded with an "unreasonable" counteroffer of $190 million.

"Time is of the essence," FDEM director Kevin Guthrie wrote to Cava. "We must act swiftly to ensure readiness and continuity in our statewide operations to assist the federal government with immigration enforcement."

The plan was met with pushback from environmentalists, conservationists, and Florida residents. Local advocates have organized a protest, and Miccosukee tribal leadership has asked the state to move the immigration detention site away from tribal homelands.

Cava said in a statement that the critical location required "considerable review and due diligence" as the "impacts to the Everglades ecosystem could be devastating." Her office said the county sent a letter listing multiple concerns about the project.

Here's what to know.

What is 'Alligator Alcatraz'?

On June 19, Uthmeier posted a video to X suggesting that the "virtually abandoned" Miami-Dade Collier Training and Transition Airport, a 39-square-mile airport facility with a 10,500-foot runway, could be easily converted into a temporary immigrant detention center to aid in Florida's efforts to locate and deport "criminal aliens."

"I call it Alligator Alcatraz," he said, over a pounding rock beat. "It’s 30 square-mile-area is completely surrounded by the Everglades. It presents an efficient low-cost opportunity to build a temporary detention facility because you don’t need to invest that much in the perimeter. People get out, there’s not much waiting for 'em other than alligators and pythons.

"Nowhere to go, nowhere to hide," he added.

The move comes as both DeSantis and the Trump administration ramp up measure to seize and deport undocumented immigrants in Florida and across the country, and weeks after President Donald Trump ordered federal agencies to reopen the original infamous Alcatraz, long a San Francisco tourist attraction, to "house America’s most ruthless and violent Offenders."

“Alligator Alcatraz” should be ready to receive detainees with 5,000 beds as soon as the first week of July, Uthmeier told controversial commentator Benny Johnson on June 23. He also said the facility is intended to be temporary.

"We'll have some light infrastructure, a lot of heavy duty tent facilities, trailer facilities," Uthmeier said. "We don't need to build a lot of brick-and-mortar."

Homeland Security Director Kristi Noem said in a post Monday that the new facilities "will in large part be funded by FEMA’s Shelter and Services Program," which she said the Biden administration "used as a piggy bank" to house undocumented immigrants.

Where is 'Alligator Alcatraz'?

The facility is in Ochopee, just north of Everglades National Park and about 36 miles west of the Miami business district, CNN reported.

According to the Miami International Airport, the Dade-Collier Airport is used as a training facility for "commercial pilots, private training, and a small number of military touch-and-goes."

The facility was constructed in 1968 and originally known as the Everglades Jetport, according to the National Park Service.

https://www.tallahassee.com/story/news/politics/2025/06/24/florida-alligator-alcatraz-immigrant-detention-desantis-seizes-land/84333512007/

NATO Chief Butters Up Trump, While Touting Ukraine's 'Irreversible Path' To NATO Membership

 Before President Trump's Air Force One even touched down in The Hague to attend this week's major NATO summit, he was responding somewhat coldly when asked about his relationship with Ukrainian President Volodymyr Zelensky and whether they will meet.

The White House clarified that such a meeting will take place at some point on the sidelines of the summit, but pro-Kiev pundits are reacting to the following exchange with a reporter as an insult to Zelensky and to Ukraine...

The last time the two leaders met was in April on the sidelines of Pope Francis' funeral, which resulted in the famous photo of the two sitting face-to-face, talking intensely, in St. Peter's Basilica.

Trump only said to reporters Tuesday that he "would probably meet" with Zelensky, and reports now say that the sit-down could happen as soon as tomorrow afternoon.

The US has shut the door on Ukraine's path to NATO membership, and Trump is only expected to discuss new anti-Russia sanctions as well as purchase of a fresh weapons package from the US with Zelensky.

But NATO Secretary-General Mark Rutte is still busy touting an 'irreversible' path of Ukraine toward NATO. He said ahead of the summit's start:

"I can announce that now new estimates showing that our European and Canadian allies have stepped up, they will provide over €35 billion of additional security assistance to Ukraine for the year ahead," the NATO chief said.

Rutte said there was agreement within the alliance on the need to keep up support. 

“This is the reason why, I think also last year in Washington, NATO allies agreed that for Ukraine, there is an irreversible path of Ukraine to enter NATO,” Rutte told reporters. “That is still true today, and it will still be true on Thursday after this summit.”

Reporters at The Hague are busy contrasting Rutte's warmth and embrace of Zelensky's with Trump's apparent coolness...

Rutte is clearly trying to stay on Trump's good side, meanwhile, having issued a letter praising Trump's 'extraordinary' decision to hit Iran's nuclear sites.

The head of NATO has formally congratulated the US president in a private text message which has been revealed as follows:

The message was confirmed by the White House as authentic, after some questioned it, given how gushing it was: "You are flying into another big success in The Hague this evening,” he continued, explaining how other member states have agreed to increase their defense spending to 5 per cent of gross domestic product," Rutte wrote.

"Donald, you have driven us to a really, really important moment for America and Europe, and the world," he wrote. "You will achieve something NO American president in decades could get done."

https://www.zerohedge.com/geopolitical/nato-chief-butters-trump-while-touting-ukraines-irreversible-path-nato-membership

Where Is Iran's Uranium? Top Secret Leaked US Intel Says Core Nuclear Components 'Intact'

 Update(1605ET): Where is Iran's Uranium? Truce Highlights Mystery Over Stockpile... that's Bloomberg's latest headline over the 'biggest mystery' that remains in the war. There's also the pressing question of whether Trump's massive airstrikes from B-2 bombers actually truly destroyed the facilities and these stockpiles. 

The Iranians aren't dumb, and likely took drastic steps to further protect, conceal, or likely move these enriched stockpiles - some 400kg according to most reports - as wave after wave of Israeli warplanes hit Iran, significantly before the US sent its bombers this past weekend. It appears core components are still intact - though Iran has long maintained it is merely for peaceful nuclear energy development. 

The NY Times is currently reporting that the US operation merely set Iran's nuclear program back by a few months. And further:

US BOMBS DIDN'T COLLAPSE UNDERGROUND IRANIAN NUKE BUILDINGS: NYT

 

Early emerging intelligence also points to the stockpile having not been destroyed, which contradicts the current 'victory lap' claims being made by President Trump and some of his top officials. In a huge development below is fresh CNN reporting based on a leaked assessment by the Defense Intelligence Agency (DIA):

The assessment, which has not been previously reported, was produced by the Defense Intelligence Agency, the Pentagon’s intelligence arm. It is based on a battle damage assessment conducted by US Central Command in the aftermath of the US strikes, one of the sources said.

The analysis of the damage to the sites and the impact of the strikes on Iran’s nuclear ambitions is ongoing, and could change as more intelligence becomes available. But the early findings are at odds with President Donald Trump’s repeated claims that the strikes “completely and totally obliterated” Iran’s nuclear enrichment facilities. Secretary of Defense Pete Hegseth also said on Sunday that Iran’s nuclear ambitions “have been obliterated.”

Did Iran move its enriched uranium before the US bombs hit?...a likely scenario

One unnamed defense official quoted in the report says centrifuges are largely "intact." And more based on the apparently 'Top Secret' leaked DIA intel report:

“So the (DIA) assessment is that the US set them back maybe a few months, tops,” this person added.

The White House acknowledged the existence of the assessment but said they disagreed with it.

So this appears yet another case of the White House disagreeing with its own intelligence community (IC) - in an ongoing awkward situation which has Iraq war vibes. However, without doubt the IC is still working on an overall consensus, based likely on several different intel threads, and across agencies.

One obvious danger from the perspective of Western decision-makers (and Israel): if Iran was not intent on getting a bomb before, they likely are now - given their very existence is under threat. More of the WH reaction to the leak:

As we stated before, it is especially the Iranian hardliners which will understand the 'two paths' and existential question facing Iran:

1) Become a failed state like Libya after 'giving up' nuclear or WMD potential (precisely as Gaddafi did when offered 'incentives' by Bush/Cheney/Rice).

2) Or, become North Korea and you are immune from regime change wars launched by the West.

For the Iranians, the question of negotiations with the US at this point means negotiating their own demise - given they have already been relentlessly bombed. While the US may not be openly calling for regime change in Tehran, the reality is that many within Israel's top leadership, including Netanyahu, have.

Tehran certainly knows this, and has likely already chosen path #2 - at a moment Israeli leadership is probably worried about a future nuclear dirty bomb going off in Tel Aviv. In many ways, Trump's brazen bombing operation - which as usual saw the commander-in-chief completely bypass Congress, took things from bad to worse. We could for now with this Trump-backed ceasefire just be witnessing a 'pause' before a much worse storm on the horizon, whether that happens days, weeks, or months from now.

Update(1300ET)The ceasefire seems to finally be holding as of early evening local time, despite the ongoing accusations of earlier violations when it was to take effect.

"Both Israel and Iran wanted to stop the War, equally! It was my great honor to Destroy All Nuclear facilities & capability, and then, STOP THE WAR!" President Trump said on Truth Social. Were they all destroyed?

And China has belatedly weighed in, with Foreign Minister Wang Yi saying China supports Iran in achieving a "genuine ceasefire" - but following Beijing's condemnation of the US for striking the country’s nuclear sites.

"China supports Iran in safeguarding its national sovereignty and security, and, on that basis, achieving a genuine ceasefire so that people can return to normal life," Wang expressed to his Iranian counterpart, Abbas Araghchi, in a phone call. 

But here is the clearest indicator yet that skies have cleared of Israeli warplanes and return fire over Tehran:

Iranian airspace partially reopened today, following the country’s ceasefire with Israel after 12 days of hostilities, according to aviation monitoring company FlightRadar24.

“Iranian airspace is now open to international arrivals and departures to/from Tehran with prior permission,” FlightRadar24 said on X. Iraqi airspace has also reopened, it added.

Also, Iranian media is currently airing footage of a large crowd assembled in central Tehran, in an act expressing solidarity with the country’s armed forces. IRNA, Fars, and Mehr are covering the gathering in Revolution Square. Now each side is declaring 'victory' to some extent, but whether the ceasefire will actually stick is anyone's guess.

AFP/Getty Images

* * *

Update(1116ET)On Tuesday the head of Iran's nuclear energy program vowed that the country will continue its nuclear program uninterrupted, despite the Trump-ordered weekend heavy bombings of three key nuclear and uranium enrichment sites.

AEOI (Atomic Energy Organization of Iran) head Mohammad Eslami said on state television that "plans for restarting [the facilities] have been prepared in advance" and that measures ensuring continued production are in place.

"Despite the evil conspiracies of its enemies," the AEOI said in the statement, "this organization will not allow the path of development of this national industry to be stopped."

"This action, contrary to international law, was unfortunately carried out in the shadow of indifference and even with the cooperation of the International Atomic Energy Agency," the statement read.

This is not surprising, but what is surprising is just how bold and provocative a statement that Russian Foreign Minister Sergei Lavrov just made. On the question of Iran's now 'missing' (or 'unknown whereabouts') enriched uranium stockpiles, he laid out that Iran has every incentive to hide it from IAEA inspectors

"What guarantees are there that the IAEA will not leak this information to the US or Israel?" he posed in public statements on the American military action against Iran, while emphasizing that arms control will fail due to these American-Israeli surprise attacks which killed negotiations.

Indeed the Iranians too have long feared that international inspectors could be conduits of information on sensitive facilities for Israeli and US intelligence. And now these same facilities are being targeted for destruction.

* * *

Despite last night's big news of a Trump-declared ceasefire, the reality is it was little more than an effort at a pause, and it's increasingly looking like neither side actually signed onto. Or at least each side issued 'confirmation' with a lot of conditions, and there wasn't even firm agreement on the start time.

As the US- and Qatar-brokered ceasefire deadline closed in, Israel and Iran kept exchanging lethal blows overnight, with Israel hitting various targets in Iran, killing nine people in northern Iran and reportedly assassinating yet another nuclear scientist, while Iran killed at least four Israelis in a devastating hit on an apartment tower. At eight minutes after midnight in Washington, President Trump used his Truth Social account to announce the ceasefire was in effect, and to urge continued compliance.

But as of Tuesday morning, Trump's message is one of extreme frustration. His fiery statement to the press just moments before boarding Marine One included the declaration, "We basically have two countries that have been fighting so long and so hard that they don't know what the f*ck they're doing. You understand that." Watch the comments below:

The warring sides have not heeded Trump's call to immediately halt, and at the very moment the US president has been issuing desperate messages and warnings, explosions are still being observed in Israel and Iran.

Just after the president addressed the press, Israel's Channel 12 said IDF warplanes have launched another round of strikes against Tehran. This also just as Trump issued a new Truth Social post demanding that Israel not attack Iran. "All planes will turn around and head home," he wrote, almost as a directive, so that "Nobody will be hurt" as "the Ceasefire is in effect!"

A big question remains whether he's bringing real leverage to bear against Israel, or if the latest 'objections' are more just show to provide political cover for himself for the negative fallout as war persists. But his current deeply frustrated tone is a reminder of the failures to achieve peace in Ukraine, and the past Ukraine-Russia related statements to just 'let them fight it out' of the last months.

Axios' Barak Ravid offers up an explanation (per machine translation):

Israeli official: Trump called Netanyahu and asked him not to attack Iran at all. Netanyahu told Trump that he could not cancel the attack and that some kind of response was needed to Iran's violation of the ceasefire. Ultimately, it was decided to significantly scale down the attack and cancel the attack on a large number of targets

Times of Israel has also freshly commented on the obvious miscommunication and apparent growing rift among allies concerning plans for the Iran conflict, and whether to halt the fighting of keep up the attacks:

Trump was sending out posts on his Truth Social platform promising that Israel will not strike Iran “after he knew we would attack,” an Israeli official tells the Kan public broadcast.

Israeli officials confirmed that the IAF struck an Iranian radar site north of Tehran, after Iran fired two ballistic missiles at Israel after a ceasefire had taken effect.

But it's still possible, amid the finger-pointing, that ceasefire could take effect Tuesday, though it's anyone's guess precisely when.

In the overnight hours there was this large Israeli attack on Tehran even after ceasefire was announced to the world:

It may in the end have little substantive to make it stick, and might prove merely a pause or temporary respite for both sides to assess damage and regroup. Here's how we got here, via Newsquawk:

  • US President Trump announced that Israel and Iran agreed to a complete and total ceasefire, from 05:00BST/00:00ET, which would last for 12 hours. After which, the war would be considered officially ended.
  • Under the ceasefire announced by Trump, Iran would stop striking Israel in six hours (at midnight ET on Tuesday), and Israel is expected to stop striking Iran 12 hours after that (at noon ET Tuesday). Then, after another 12 hours, or at midnight ET Wednesday, the war will be considered over, a White House official confirmed to CBS News.
  • Strikes continued into and after the Iranian proposed time of 01:30BST/20:30ET. After the Trump deadline of 05:00BST/00:00ET, Iran is said to have fired some missiles at Israel, though they claim it was fired just before the deadline.
  • At 06:04BST/01:04ET Trump posted that the "ceasefire is now in effect".
  • At 07:17BST/02:17ET Israeli PM Netanyahu confirmed the ceasefire is now in effect, war achieved its goals, will respond forcefully to any violations. PM's office adds that Netanyahu will deliver a statement later today.
  • The ceasefire agreement seems to have broken down only 4 hours after being in effect, with the IDF suggesting it had detected and intercepted fresh ballistic missiles from Iran. In response to this latest attack, the IDF Minister instructed the military to respond “forcefully” to Iran’s violation of the ceasefire. Iran has denied firing missiles at Israel after the ceasefire.

Iran's overnight missile strike on a residential home in Be’er Sheba resulted in some shocking scenes of people seeking to get out and survive the nightmarish ordeal:

Aftermath and rescue efforts of the hit on the Beersheba residential building:

Israel is now feeling the drive for vengeance for this and other devastating blows from the Islamic Republic, despite Trump in this rare moment expressing that he's "really unhappy" with Israel. "Bring your pilots home, now!" - is the message not being heeded.

https://www.zerohedge.com/geopolitical/israeli-official-confirms-rift-ceasefire-fails-trump-vowed-israel-wont-strike-after-he