, expects topline data in 3Q 2026
- Reported Q4 and full-year 2025 results, ending 2025 with €292 million in cash
- Reiterates plan to submit NDA for deucrictibant IR for on-demand HAE treatment in 1H 2026
Thursday, April 2, 2026
Pharvaris completes enrollment in pivotal CHAPTER-3 deucrictibant XR HAE prophylaxis study
Trump: US to hit Iran extremely hard over next 2-3 weeks
United States President Donald Trump said the US military will hit Iran "extremely hard" over the next "two to three weeks."
"We're going to bring them back to the stone ages, where they belong," Trump said. "In the meantime, discussions are ongoing," he added, noting that while regime change "was not" Washington's goal, it took place "because of all of their original leaders' death."
"If during this period of time no deal is made, we have our eyes on key targets. If there's no deal, we're going to hit each and every one of their electric generating plants very hard and probably simultaneously," he said.
IDF claims it killed over 40 Hezbollah members
The Israel Defense Forces (IDF) declared on Thursday that its troops had eliminated more than 40 Hezbollah operatives in Lebanon during the past day.
"In the past 24 hours, the Israeli Air Force struck dozens of headquarters, weapons storage facilities, launch sites, and anti-tank missile positions. The Israeli Navy also conducted a precise strike targeting a Hezbollah weapons storage facility in southern Lebanon," the IDF stated on Telegram.
In addition, the military also shared that the 146th and 162nd divisions had located several weapons and destroyed yesterday dozens of Hezbollah sites in southern Lebanon.
https://breakingthenews.net/Article/IDF-claims-it-killed-over-40-Hezbollah-members/66004730
Ayatollah Breaks Silence, In Written Message Praises Hezbollah & Shia Leaders Of Iraq
The new, younger Ayatollah Khamenei - who may have been wounded in the early days of US-Israeli strikes, hasn't been seen in any public way, not even on TV, throughout the war. There have not so much as been any official recent images of him circulated.
But Mojtaba Khamenei has apparently been issuing some limited written statements, mainly encouraging foreign proxies in their joining the war against US and Israeli forces in the region. State media has indicated he's not making public appearances given the ongoing relentless bombing campaign and the Islamic Republic's wartime footing.
After a long period of relative silence, a message from Khamenei was publicized on Monday. In the message attributed to him, he "expressed his appreciation to the supreme religious authority (in Iraq) and the people of Iraq for their clear stance against aggression against Iran and their support for our country," Iran’s ISNA news agency said, referring to the Iraq-based Grand Ayatollah Ali Sistani. Sistani is based in Iraq and has long been a highly revered Shia cleric in the region.
The 56-year old Khamenei has on Wednesday apparently broken his silence again, this time praising Hezbollah for joining the war against Israel. Hezbollah has been launching hundreds of rockets on northern and central Israel, amid an emerging ground campaign in southern Lebanon, also as Israel bombs Beirut from the air.
In the new words carried by Iranian state media, he praised Hezbollah for its "perseverance, steadfastness and patience" against "the most ruthless enemies of the Islamic world."
Meanwhile, the CIA and Mossad are said to be trying to uncover Mojtaba Khamenei's whereabouts and status. His 86-year old father did not appear to have been in hiding at all when he was slain by airstrike on the very first day of Operation Epic Fury.
The most likely explanation could be that the younger Khamenei is directing the war from a much more secure and hidden setting, for example a deep underground bunker - or in a remote part of the country.
But some analysts have questioned why he wouldn't make a video address, even if pre-recorded, offering to the world proof that he is a alive and is running the country and war. As for the most visible day-to-day leader, this is parliament speaker Mohammad Bagher Ghalibaf.
https://www.zerohedge.com/geopolitical/ayatollah-breaks-silence-written-message-praises-hezbollah-shia-leaders-iraq
France Approves Record Number Of Asylum Applications In 2025, Up 12% YoY
The latest data released by the National Court of Asylum reveals a historic statistical milestone: asylum grants in France have reached an unprecedented peak.
In 2025, a record 78,782 individuals were granted asylum, marking a 12 percent increase over the previous year. The recognition rate has also climbed to an all-time high of 52.1 percent – or 47.1 percent when excluding unaccompanied minors.
The initial stage of the asylum process is managed by the French Office for the Protection of Refugees and Stateless Persons (OFPRA). If a claim is denied, applicants may appeal to the National Court of Asylum. While various forms of protection exist, the ultimate goal for many is the status of “refugee,” as it opens rights similar to those of the French in most areas, including social welfare, education, and housing.
The asylum system remains highly accessible, despite President Emmanuel Macron saying year after year that France needs to reduce immigration, just as he did in 2023.
“Are we flooded with immigration? No. You cannot say that. But the current situation is not sustainable, and we need to reduce immigration significantly, starting with illegal immigration. We have a duty to deliver,” the French president said at the time.
Polling shows the vast majority of French want a reduction in immigration, and even a majority of women want zero immigration, both legal and illegal.
France already has the largest Muslim population in Europe, leading to serious cultural, societal, and even security problems. Unlike policies debated or implemented in nations like Italy or Denmark, which seek to reduce the ability for individuals to apply for asylum, France has very generous laws, including allowing those already present on French soil to apply for asylum directly. This creates a significant challenge for the state, as even when applications are denied, authorities have an extremely difficult time removing people. Macron, for instance, stated his goal was a 100 percent deportation rate. France’s actual deportation rate has remained in the teens since then, averaging around 15 percent.
In fact, France has gone from record to record in terms of overall immigration every single year. Last year, Remix News reported that a record 6 million foreigners live in France, after a record 400,000 migrants arrived in the country in 2024. Earlier this year, Remix News reported that a record number of first-time residency permits were issued in 2025.
Nevertheless, despite soaring public pressure, more asylum applications are being approved than ever. Even during the peak of the 2015 migration crisis, France did not grant asylum at these levels. Wars continue to be a major factor. For the second consecutive year, Ukrainians represent the largest group of asylum seekers, followed closely by nationals from the Democratic Republic of the Congo and Afghanistan.
Beyond geopolitics, the increasingly broad jurisprudence of the National Court of Asylum plays a pivotal role.
In 2025, the court recognized automatic refugee status for all people from the Gaza Strip, then from the West Bank.
In other words, Palestinians have almost virtually unlimited access to French territory.
The court also recognized an automatic right to women from Iran and Somalia, which are deemed unfriendly states for women.
Similar protections were extended to homosexual individuals from Egypt, Guatemala, and, as of late 2024, Sri Lanka.
Once again, this liberal attitude towards asylum is not backed by the French public, with polling showing that 61 percent of the French want the right of asylum restricted in the country.
According to the BVoltaire publication, there is an “urgent call to reform. Proponents argue that France must consider renegotiating international conventions and amending the Constitution, asserting that both the efficiency of the State and the preservation of French identity are currently at risk.”
https://www.zerohedge.com/geopolitical/france-approves-record-number-asylum-applications-2025-12-yoy
Wednesday, April 1, 2026
'Trump’s MFN Pricing Expected To Delay More European Drug Launches'
Following Insmed’s decision to hold off on launching a newly approved lung disease drug in Europe, experts anticipate more companies will do the same as they seek to avoid price erosion in the U.S. Will Chinese biotechs fill the void?
Despite receiving European approval for inflammatory lung disease drug Brinsupri last November, Insmed is holding off on launching the product due to lingering questions around President Donald Trump’s Most Favored Nation drug pricing initiative. The company is far from the only biopharma reevaluating their global launch strategies in light of MFN. As the far-reaching effects of the policy unfold, experts warn that retreating from overseas markets could have unintended consequences—including providing a springboard for Chinese biotechs.
In addition to Insmed, Ligand Pharmaceuticals, United Therapeutics and multiple other companies have discussed how MFN is shaping their ex-U.S. strategies. Many other drugmakers are evaluating their strategies in private. Matthew Majewski, vice president at Charles River Associates (CRA), told BioSpace that companies working in various therapeutic areas have asked his team whether they should be launching in the EU and other MFN reference markets.
Companies have questioned whether they can limit launches to the markets where they can charge the most to avoid eroding U.S. prices, Majewski explained. However, that approach has a flaw. As Eva Marchese, vice president at CRA, told BioSpace, a new EU pharma regulatory package contains provisions to stop companies from cherry-picking EU countries.
Without the package, a drugmaker could limit launches to countries such as Germany. With the package, the U.S. price could be tied to the Czech Republic and Spain. A CMS assessment found Germany’s purchasing power is 83% of that of the U.S., while in the Czech Republic and Spain it is 64%.
If the Trump administration pushes ahead with its proposed MFN models, drugmakers will need to either accept lower prices in the U.S., persuade reference countries in the EU and other regions to pay more or restrict where they launch medicines. Majewski described the situation as a “game of chicken.” Unless someone backs down, Majewski said some drugs might not reach the EU in “the short-ish term.”
Nerea Blanqué-Catalina, a partner in global market access, pricing and sustainability at Alira Health, agreed, even going so far as to suggest that drug availability in the U.S. and Europe could diverge to the extent that there are effectively two different standards of care.
The situation has led experts to start considering what happens if companies avoid launching drugs in Europe or set high prices that severely limit uptake. One possibility is that Chinese biotechs will fill the gap.
Filling the Void
Typically, multiple companies are developing molecules for every major drug target. If one company decides against launching in the EU, a rival that is less price-sensitive could quickly introduce a molecule with the same mechanism of action.
Allistair Booth, a partner at Pinsent Masons, told BioSpace via email that Chinese biotechs “are very well placed to take advantage of any market anomalies MFN creates.” Booth estimated that the cost of drug development in China may be low enough to enable commercially viable returns on ex-U.S. products.
Majewski said biopharma companies are “saber-rattling” about the threat of Chinese biotechs claiming markets abandoned by U.S.-focused drugmakers over MFN concerns. Yet he agrees that companies from China, Europe or other regions could step up if new drug launches are restricted to the U.S.
The consequences of rivals claiming overseas markets could come back to the U.S. market. If a company can set a price that is acceptable to EU payers, Majewski sees no barrier to them bringing the product to the U.S. and undercutting companies that have avoided MFN reference markets. Citing that scenario, Majewski predicted that companies with drugs that can be copied will conclude that they need to launch in the EU despite MFN dictating that U.S. prices must drop as a result.
For now, though, experts who spoke with BioSpace maintain that, in the near term, a U.S.-only strategy is likely to win out. Blanqué-Catalina foresees MFN limiting which drugs launch in the EU for at least the next five years.
Concern about reputational risk could slow the divergence, as drugmakers headquartered in Europe would feel “very weird” to only launch a medicine in the U.S., Marchese said. However, such pressures only apply to a subset of the top global drugmakers. Majewski agreed that for now, European patients will miss out on novel therapeutics.
“U.S. prices need to come down, and European prices need to come up a little bit in order to meet this happy medium. There could be some pain while we play this game,” Majewski said. “Long term, there’s hope for the future that we’ll figure it out.”
https://www.biospace.com/business/trumps-mfn-pricing-expected-to-delay-more-european-drug-launches
United Arab Emirates ready to help US open Strait of Hormuz by force: WSJ
The United Arab Emirates is reportedly preparing to help the US fight Iran and open the Strait of Hormuz by force after being repeatedly struck by Iranian drones and missiles since the war began, Arab officials said.
The UAE is lobbying the United Nations Security Council to pass a resolution that would authorize a military operation to end Iran’s grip on the critical trade route, officials told the Wall Street Journal.
The operation would see the UAE become the first Persian Gulf country to join the war against Iran, with Abu Dhabi calling on European and Asian military powers to join the coalition to open the strait.
Along with opening the Strait of Hormuz, the UAE is also calling for the US to occupy strategic islands near the oil-critical Strait of Hormuz, including Abu Musa, which Abu Dhabi claims but is currently held by Iran, officials said.
Bahrain, a close US ally in the region that hosts America’s Fifth Fleet, is sponsoring the UN resolutions, with a vote expected on Thursday, according to the WSJ.
Russia and China, allies of Iran who sit on the UN’s Security Council, would veto the resolution.
Nations in the Gulf, Europe and Asia have all called for the Strait of Hormuz to be opened as it serves as a key pipeline for 20% of the world’s oil supply.
Iran effectively closed the Strait to anyone it deems its enemies after the US and Israel waged war on the Islamic Republic.
Tehran approved a bill on Tuesday to charge a toll to all ships passing through the strait, demanding up to $2 million per vessel.
President Trump has repeatedly ordered Iran to open the waterway after oil prices surged, with the US calling on its allies to help open the strait by force.
Other countries, however, have hesitated to commit their militaries to open the waterways given the threats from Iranian mines and drones.
The UAE, which has been vocal against Iran and its closure of the Strait of Hormuz, has seen attacks from Tehran soar in recent days after the Gulf state signaled its willingness to join the war.
Iran fired nearly 50 ballistic missiles, cruise missiles, and drones against the UAE on Tuesday alone, leaving at least four people injured after debris fell on their Dubai home following an interception.
Repeated attacks near the Dubai International Airport, one of the world’s busiest transportation hubs, have also led to reduced air traffic and tourism to the UAE.
https://nypost.com/2026/04/01/world-news/uae-ready-to-help-us-open-strait-of-hormuz-by-force-report/
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