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Wednesday, April 8, 2026

Trump says US to work with Iran as tensions persist after ceasefire

 Summary

  • A drone attack hit Saudi Arabia’s East-West oil pipeline on Wednesday, damaging a key export route carrying crude from the Persian Gulf to the Red Sea, hours after a ceasefire between the United States and Iran took effect, the Financial Times reported.

  • Chairman of the Joint Chiefs of Staff Air Force General Dan Caine said the ceasefire with Iran was only a temporary halt and forces remained ready to resume operations.

  • Iran could reopen the Strait of Hormuz on Thursday or Friday ahead of talks with the United States in Pakistan if a ceasefire framework is agreed, Reuters reported, citing a senior Iranian official.

  • President Donald Trump said in a post on Truth Social on Wednesday that the US would work with Iran after what he called a “regime change,” ruling out uranium enrichment and signaling possible sanctions relief.

  • Kuwait reported damage from Iranian drone attacks after the ceasefire, while the UAE said its air defenses were responding to a missile threat.

  • Iran said its Lavan Island refinery was hit in an attack after the ceasefire, with no casualties and crews working to contain a fire.

  • Iran’s parliament speaker will lead Tehran’s delegation in Friday talks with the US, with sanctions, nuclear and regional issues on the agenda.

  • President Donald Trump announced Tuesday evening that the United States had reached a two-week ceasefire agreement with Iran.

Supernus (SUPN) Acquires Key Assets from Navitor

 

  • Supernus Pharmaceuticals SUPN +0.08% 
    87
     has acquired significant assets from Navitor Pharmaceuticals, enhancing its portfolio in central nervous system treatments.
  • The acquisition involves a Phase 2b study and potential milestone payments up to $350 million.
  • Supernus Pharmaceuticals demonstrates strong financial health with a robust balance sheet and high institutional ownership.

Supernus Pharmaceuticals (SUPN) has finalized an Asset Purchase Agreement with Navitor Pharmaceuticals, acquiring significant assets related to the compound NV-5138, also known as SPN-820. The detailed agreement includes the transfer of intellectual property rights, inventory, regulatory materials, and associated goodwill from Navitor.

This transaction builds upon prior agreements between the two companies, namely a Development and Option Agreement from April 2020 and a Memorandum of Understanding from May 2025. The purchase price involves Supernus conducting a Phase 2b study and potential milestone payments up to $350 million, dependent on the attainment of specific development, regulatory, and commercial milestones.

Supernus has committed to diligently pursuing these milestones. However, if the Phase 2 study is deemed unsuccessful, the company reserves the right to discontinue further efforts regarding the commercialization of SPN-820.

https://www.gurufocus.com/news/8779911/supernus-supn-acquires-key-assets-from-navitor-pharmaceuticals

China approves GSK's Exdensur for treating chronic rhinosinusitis

 GSK PLC on Wednesday said its Exdensur drug, has been approved in China as an add-on therapy for the treatment of chronic rhinosinusitis with nasal polyps.

The approval of depemokinab, of which Exdensur is the brand name, for chronic rhinosinusitis in addition to intranasal corticosteroids by China's National Medical Products Administration follows an earlier approval of the drug as an add-on treatment for severe asthma in patients over 12 by the same regulator.

GSK said the drug is the only ultra-long-acting biologic in China for the treatment of chronic rhinosinusitis with nasal polyps, which are growths in the nose or sinuses caused by inflammation. Half of the patients with the conditions are unable to get it under control, and up to 85% have underlying type 2 inflammation associated with more severe disease.

It is the sixth regulatory approval for the anti-asthma drug developed by the London-based pharmaceutical firm, which has also been authorised for marketing in the EU, the US, and Japan for either asthma or chronic rhinosinusitis conditions.

https://global.morningstar.com/en-gb/news/alliance-news/1775635167227424200/china-approves-gsks-exdensur-for-treating-chronic-rhinosinusitis

Nurix pushes leukemia drug toward full approval with Phase 3 due mid-2026



Nurix Therapeutics (Nasdaq: NRIX) reported Q1 2026 results and program milestones. Key clinical moves include ongoing Phase 2 DAYBreak CLL-201 to support Accelerated Approval, a planned Phase 3 DAYBreak CLL-306 to start midyear 2026, and a 2026 IND target for a tablet bexobrutideg in immunology.

Financials: revenue $6.3M, R&D $84.1M, net loss $87.2M, and cash and marketable securities $540.7M as of February 28, 2026.

Mesoblast IND Clearance to Directly Proceed to Registrational Trial for OK of Ryoncil® in Duchenne

Mesoblast (Nasdaq: MESO) announced FDA IND clearance to proceed directly to a registrational trial of Ryoncil® in Duchenne muscular dystrophy (DMD) on April 7, 2026. The randomized trial will enroll 76 patients aged 5–9, dosing 7 infusions of 2 x 106 cells/kg over 9 months, with time-to-stand at nine months as the primary endpoint. Mesoblast cites Ryoncil’s approved pediatric safety profile in steroid-refractory aGvHD, preclinical DMD efficacy, an FDA-approved manufacturing process, and a collaboration with Parent Project Muscular Dystrophy to support enrollment.

Activist investor renews its criticism of Novavax

 Hedge fund Shah Capital has fired another broadside at vaccine developer Novavax, saying it intends to vote against the re-election of the board and executive pay packages at its forthcoming annual meeting.

The activist investor, which holds a 9% stake in Novavax and last year called for the company to be put up for sale, said it was taking a stand against the current board and management, accusing them of overseeing a destruction in shareholder value.

It is not starting a proxy fight, however, as it will be in a minority against "an entrenched eight-member board," but is looking for support from other shareholders in the company, including ISS and Glass Lewis.

Chief among its criticisms is Novavax's failure to build sales of its protein-based COVID-19 vaccine Nuvaxovid/Covovax, a latecomer in the market, which has struggled to gain traction against mRNA-based rivals from Moderna and Pfizer/BioNTech, despite negative sentiment toward the latter technology emanating from the US.

Shah has also tried to block the re-election of the board and executive compensation in previous years, saying Novavax's management was "clinging" to a failed strategy, although, its criticisms quietened in the wake of the company signing a $1.2 billion alliance with Sanofi in 2024 and a $530 million non-exclusive licensing deal with Pfizer for its Matrix-M vaccine adjuvant.

Its latest letter to the board notes that the Sanofi partnership is not benefitting Novavax yet, adding "for Nuvaxovid to achieve only ~1% share or ~$22 million in revenues in 2025 is completely unfathomable and frankly unacceptable for the best-in-class covid vaccine on efficacy and safety which is non-mRNA."

Shah is also unhappy about delays to phase 3 trials of a combination COVID-19/influenza vaccine that lies at the centre of their agreement, "even with better clinical results compared to competition for a lucrative ~$5+ billion combo vaccine category."

The criticism comes despite Gaithersburg, Maryland-based Novavax receiving $225 million in milestone payments from Sanofi in relation to the alliance last year.

Overall sales of Nuvaxovid fell in the fourth quarter, but vaccines' total sales in 2025 rose to $625 million from $190 million in 2024, according to Novavax's recent fourth-quarter results update. Novavax only books sales in territories where it is the commercial lead, as Sanofi has taken over commercialisation and distribution of the shot in most global markets. The company is predicting revenues of $35-$45 million from Nuvaxovid this year.

Shah's concerns also relate to the predicted market share for Nuvaxovid of less than 10% this year, arguing it should be around 30%, as well as "continuing massive R&D expenses" totalling $1.35 billion in 2023 to 2025, inadequate cost-cutting, and "cash hoarding" by management that the hedge fund says "is not prudence, but a lack of strategic conviction."

It wants the company to trim back R&D spending, retire a $225 million convertible bond that is tied to high interest, undertake a share buyback, and slash the management team by a third, whilst reducing the board from eight to five and appointing new members "with emphasis on pragmatic entrepreneurial experience" to turn Novavax around.

"We would like to see a like-minded strategic long-term investor taking 10-20% ownership position to reshape Novavax entirely," says the investor in a letter sent to the company today, which is signed by founder and managing partner Himanshu Shah.

So far, Novavax has not responded to the letter.

https://pharmaphorum.com/news/activist-investor-renews-its-criticism-novavax

Ex-Rio Tinto Boss to List Seabed Mining Firm in $1 Billion Deal

 

American Ocean Minerals Corp., a deep-sea exploration company led by former Rio Tinto Chief Executive Officer Tom Albanese, is combining with Odyssey Marine Exploration Inc. in a reverse merger, according to people with knowledge of the matter.

The all-stock deal values the combined company at about $1 billion on a pro forma equity basis, said the people, who asked not to be identified discussing private information.

https://www.bloomberg.com/news/articles/2026-04-08/american-ocean-minerals-said-to-reach-1-billion-odyssey-merger