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Tuesday, March 31, 2020

Idexx Labs extends rally

Veterinary diagnostics and software developer IDEXX Laboratories (IDXX +2.4%) is up again, albeit on below-average volume. Shares have rallied 48% since bottoming at $168.65 on March 23.
COVID-19-stoked investors appear to be reacting to its announcement that it has tested “thousands” of dog and cat specimens in its reference lab network and has not yet detected a single case of coronavirus infection, an undoubtedly reassuring outcome for humans.
https://seekingalpha.com/news/3556892-idexx-labs-extends-rally-up-2

Trump pitches infrastructure for phase four Covid-19 relief

“With interest rates for United States being at ZERO, this is the time to do our decades long awaited Infrastructure Bill,” President Trump writes via Twitter.
“It should be VERY BIG & BOLD, Two Trillion Dollars, and be focused solely on jobs and rebuilding the once great infrastructure of our Country!”
Trump signed the third bill to provide federal aid in response to the coronavirus epidemic — the $2.2T CARES Act — on Friday.
Earlier, Senate Majority Leader Mitch McConnell said lawmakers should “wait and see” how the crisis unfolds before taking on a fourth.
Among many potentially relevant tickers: CAT, EXP, FCX, FLR, GVA, VMC
https://seekingalpha.com/news/3556851-trump-pitches-infrastructure-for-phase-four-covidminus-19-relief

Line survey finds 7% of users in Tokyo have at least one coronavirus symptom

A survey of Line Corp’s (3938.T) chat app users in Tokyo and neighboring prefectures in partnership with Japan’s health ministry found 7.1% of respondents in the capital reporting at least one of the symptoms of the coronavirus.
A total of 443 people in Tokyo are infected with coronavirus according to official figures. Line’s survey found that 7.1% out of 63,843 people responding in Tokyo reported at least one of the symptoms of the virus, including high fever or a bad cough, between March 27-30.
That puts the number of people reporting symptoms from a limited sample at around 4,500, although having such symptoms does not prove coronavirus infection and the respondees were self-selecting.
https://www.reuters.com/article/us-health-coronavirus-line/line-survey-finds-7-of-users-in-tokyo-have-at-least-one-coronavirus-symptom-idUSKBN21I0LJ

Mass disinfections to combat coronavirus pose another health hazard

A drone dispersed clouds of disinfectant in the sky above Indonesia’s second-largest city Surabaya on Tuesday, a response to the coronavirus pandemic which is catching on around the world despite warnings from health experts.
Mass disinfections, often by workers in protective gear resembling characters from the comedy film Ghostbusters, have become a common sight — from Turkey’s Grand Bazaar to bridges in Mexico and migrant workers in India.
But the visually-impressive measures taken to contain the fast-spreading virus which has killed over 37,000 people globally, have been criticized by disease specialists as a health hazard as well as a waste of time and resources.
“It’s a ridiculous image seen in many countries,” said Dale Fisher, an infectious diseases expert in Singapore who chairs the Global Outbreak Alert and Response Network coordinated by the World Health Organization.
“I don’t believe it adds anything to the response and could be toxic on people. The virus does not survive for long in the environment and people do not generally touch the ground.”
A spokesman for Surabaya’s major said the use of drones for disinfection was necessary in areas with confirmed cases because the virus “can be anywhere”.
Febriadhitya Prajatara compared the benzalkonium chloride disinfectant, which can cause skin irritations in high concentrations, to “soap” and said it would help “weaken the virus so it won’t enter our body”.
Coronavirus is a contagious respiratory disease that spreads through droplets from the nose or mouth via coughing or sneezing.
People can also become infected by contacting something contaminated before touching their own nose, mouth or eyes.
Paul Tambyah of the Asia Pacific Society of Clinical Microbiology and Infection said handwashing and targeted cleaning of commonly-touched surfaces like elevator buttons offered better protection than mass disinfecting.
“It (spraying) is probably a cheap and visible way of doing it, but careful attention to personal and environmental hygiene is probably more effective,” said Tambyah.
Indian health workers caused outrage on Monday when they used hose pipes to douse migrant workers in the northern state of Utter Pradesh, amid fears the movement of people from cities to the countryside risked spreading the virus.

FURTHER TRANSMISSION

In Malaysia, under nationwide lockdown due to the virus, authorities have gone on a disinfection spree in areas with high case numbers to reduce the risk of further transmission.
But images of plumes of disinfectant spray fired from trucks into the air or from spray guns on to roads have riled health experts.
“Disinfecting roads is clearly not going to be impactful,” said Christopher Lee, a former deputy director general in Malaysia’s health ministry and an infectious disease specialist. “Waste of resources and man hours.”
Malaysia’s director-general of health Noor Hisham Abdullah said on Tuesday the government would be issuing guidelines to local authorities to make sure disinfection operations are carried out properly.
Back in Indonesia, telephone box-shaped disinfection chambers are being set up across the capital Jakarta, offering passers-by a quick blast to rid their clothes and skin of potential germs.
“I think it’s good…I feel sanitized after touching a lot of things from the bus…I feel well-protected,” said Jakarta resident Fany Anisa after exiting one of the chambers outside a bus stop in central Jakarta.
The private initiative being rolled out with the support of local authorities has been criticized by one expert who is advising the government’s virus-fighting taskforce.
“It is not good for skin, mouth and eyes, it will cause irritation,” said Wiku Adisasmito, a public health professor at the University of Indonesia.
Leong Hoe Nam, an infectious disease expert at Singapore’s Mount Elizabeth hospital, said mass disinfections are eye-catching and may boost morale but are not effective virus controls.
“It would have better effect using a water cannon to disperse people and make them go home,” he said.
https://www.reuters.com/article/us-health-coronavirus-disinfection/mass-disinfections-to-combat-coronavirus-pose-another-health-hazard-idUSKBN21I1PB

China zeroes in on coronavirus patients with no symptoms as new infections rise

China will start releasing information from Wednesday on coronavirus patients who show no disease symptoms, ordering them into quarantine for 14 days, a health official said, after the mainland witnessed its first rise in infections in five days.
As local infections peter out and new cases surface among travelers returning home, the existence of virus carriers with no symptoms is fuelling public concern that people could be spreading it without knowing they are ill.
From April 1, the daily report of the National Health Commission will include details of such cases for the first time, Chang Jile, a commission official, told a briefing. People in close contact with them face 14 days of medical observation.
Asymptomatic patients under observation numbered 1,541 by Monday, with 205 of the cases having come from overseas, the commission said separately.
Monday’s 48 new infections, and one death, in mainland China were up from 31 the previous day, the commission said, reversing four days of declines. All were imported, taking China’s tally of such cases to 771, with no new local infection reported.
Many were students returning from overseas. About 35 infected Chinese citizens are still studying abroad, with 11 already cured, education ministry official Liu Jin said.

COLLEGE EXAM

Fearing a second wave of infections sparked by such inbound travelers, China will delay its college entrance exam by a month, until July 7 and 8, China Central Television said, although Hubei province, where the virus emerged late last year, and Beijing, the capital, will get more leeway in scheduling it.
The annual two-day “gaokao” test drew more than 10 million candidates last year, state media have said.
Last week, a study in British medical journal the Lancet Public Health recommended that China extend school and workplace closures, since an earlier relaxation of curbs could bring a second peak in the outbreak by August.

“China has slowed transmission of the virus and in so doing, has passed one peak in the outbreak,” said Tarik Jasarevic, a representative of the World Health Organisation. “The challenge now is to prevent a resurgence of new cases.”
Tax authorities acknowledged the pandemic’s impact on exporters, saying they were studying policies to reduce pressure on businesses, from tax cuts to an extension of preferential policies for foreign firms.
New data from a survey of manufacturers showed that factory activity expanded in March from February’s collapse as businesses returned to work, but analysts warned that slumping external demand could prevent a durable recovery.
“The situation could be very fluid as the virus outbreak remains unpredictable,” analysts at ANZ bank said in a note. “Chinese policymakers will likely step up and expand the stimulus program if needed.”
The commercial hub of Shanghai saw 11 new imported cases on Monday, mainly among returning Chinese nationals, while Beijing had three.
Wuhan, the capital of central Hubei province, reported no new infections for a seventh straight day. Groups of medical teams in brightly colored jackets took photographs around the city as they prepared to leave.
“Thank you, Wuhan. We are back,” read a message on a building that houses a Levi’s clothing store.
By Monday, total infections stood at 81,518 in mainland China, with 3,305 deaths.
https://www.reuters.com/article/us-health-coronavirus-china-toll/china-zeroes-in-on-coronavirus-patients-with-no-symptoms-as-new-infections-rise-idUSKBN21I036

Kiniksa Pharma’s mavrilimumab shows treatment response in Covid-19

Kiniksa Pharmaceuticals (NASDAQ:KNSA) announces “early evidence” of treatment response with mavrilimumab, an investigational fully-human monoclonal antibody, in a treatment protocol in patients with severe coronavirus 2019 pneumonia and hyperinflammation.
The objective was to reduce incidence of progression of acute respiratory failure, the need of mechanical ventilation, and the transfer to the intensive care unit.
All 6 patients treated with mavrilimumab showed resolution of fever and did not progress to mechanical ventilation.
The company plans to evaluate a Phase 2/3 clinical development program pending regulatory feedback and data from treatment experiences.
Kiniksa and its collaborators are planning to commence investigator-initiated studies in parallel.
https://seekingalpha.com/news/3556739-kiniksa-pharmas-mavrilimumab-shows-treatment-response-in-covidminus-19-patients-shares-up-39

Vivus up 272% premarket on launch of telemedicine modules

Nano cap VIVUS (NASDAQ:VVUS) rockets 272% premarket on robust volume in reaction to its launch of telemedicine and remote monitoring modules of the VIVUS Health Platform. The company says the modules will enable doctors to conduct virtual office visits whether or not patients are prescribed a VIVUS product.
It expects to enroll 150-200 physicians each week.
https://seekingalpha.com/news/3556748-vivus-up-272-premarket-on-launch-of-telemedicine-modules