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Tuesday, June 1, 2021

Yale children's hospital launches long COVID-19 program

 Yale New Haven (Conn.) Children's Hospital has launched a post-COVID-19 program for teens and children still experiencing effects weeks or months after the infection, according to a news release shared with Becker's May 28. 

The program will connect pediatric patients to a network of specialists, including infectious disease experts, pulmonologists and cardiologists, based on the persistent symptoms patients are experiencing.

"This program was developed in direct response to the needs we are seeing in our patients as well as hearing from their parents and pediatricians in our community," Rebecca Ciaburri, RN, performance manager of quality and safety at Yale New Haven Children's, said in a news release. "From the teenager who had COVID-19 several months ago and still has chest tightness to the younger child who had minimal COVID-19 symptoms after a positive test, but now has headaches, we need to support our children and families who are no longer positive for the virus yet still have symptoms." 


Additionally, the children's hospital offers a program to clear athletes who've had COVID-19 to return to sports, as well as a program for the management of multisystem inflammatory syndrome — a rare condition potentially linked to COVID-19.

https://www.beckershospitalreview.com/patient-safety-outcomes/yale-children-s-hospital-launches-long-covid-19-program.html

South Korea says J&J's COVID-19 shots fully taken up

 South Korea closed its first phase of reservations for Johnson and Johnson COVID-19 vaccines on Tuesday as military personnel signed up for all 800,000 shots on offer, the government said.

South Korea received one million doses of the vaccine this week after the United States almost doubled a pledge made during President Moon Jae-in's first summit with U.S. President Joe Biden last month.

Authorities designated the vaccine for military-related personnel, including reserve forces and the civil defence corps, as well as people planning overseas business trips or diplomatic missions.

Around 3.7 million people are eligible to receive the single-dose vaccine and a total of 800,000 had signed up in less than 16 hours since reservations began on Tuesday, the Korea Disease Control and Prevention Agency (KDCA) said in a statement.

The KDCA closed the reservations at 800,000 doses, but said others can book their shots when more vaccines are available.

South Korea has inoculated 5.79 million people, or 11% of its population, with a first dose of the two-dose vaccines from AstraZeneca or Pfizer. It aims to vaccinate 14 million by the end of this month.

It said the plan is on track as more vaccine shipments are due to arrive later this month and willingness to get vaccinated appears to be rising, lured by incentives.

A survey in May showed 69.2% of respondents were willing to get vaccinated, up from 61.4% a month earlier, Lee Sang-won, a senior health official, told a briefing.

The government on Tuesday allowed people who have received at least one dose to have family gatherings without restrictions and visit nursing homes.

Those fully vaccinated will no longer be required to wear masks outdoors from July.

The country has reported 459 new confirmed cases on Monday, bringing the total tally to 140,799 infections, with 1,963 deaths.

https://www.marketscreener.com/quote/stock/ASTRAZENECA-PLC-4000930/news/AstraZeneca-nbsp-South-Korea-says-J-J-s-COVID-19-shots-fully-taken-up-35484520/

EU to decide on Astrazeneca's $39 billion Alexion deal by July 5

 

EU antitrust regulators will decide by July 5 whether to clear Anglo-Swedish drugmaker AstraZeneca's $39 billion bid for U.S.-based Alexion, a European Commission filing showed on Tuesday.

AstraZeneca sought EU approval on Monday for the deal, its largest ever in a bet on rare-disease immunology and to boost its business, which includes a fast-growing cancer medicines unit and a major COVID-19 vaccine.

The Commission can either clear the deal with or without conditions or it can open a four-month long investigation if it has serious concerns.

The UK Competition Authority and Markets Authority is also reviewing the bid which has already received the green light in the United States, Canada, Brazil and Russia.

https://www.marketscreener.com/quote/stock/ALEXION-PHARMACEUTICALS-8334/news/Alexion-Pharmaceuticals-nbsp-EU-to-decide-on-Astrazeneca-s-39-billion-Alexion-deal-by-July-5-35484631/

Sanofi halts venglustat kidney disease clinical program

 French pharma company Sanofi has announced that it has halted the clinical programme of venglustat in autosomal dominant polycystic kidney disease (ADPKD).

Although the safety profile of venglustat remains consistent with previously reported results, a Phase II/III trial of the drug did not meet its futility criteria.

In addition, the study confirmed venglustat effectively inhibits the glycosphingolipid (GSL) pathway by demonstration a reduction in the lip GL-1.

The STAGED-PKD study was stopped for futility after an independent analysis of the annualised rate change in total kidney volume (TKV) in patients receiving venglustat compared to placebo.

In a statement, Sanofi said that trends from this analysis showed venglustat did not provide meaningful reduction in TKV growth rate – the primary endpoint of stage one of the study.

The company added that the analysis suggests the reduction of GSLs may not play a significant role in the prevention of kidney cyst growth, meaning it may not be a primary pathway associated with the progression of ADKPD.

“The venglustat development programme started with our confidence in the promise of a potential breakthrough treatment to address the unmet needs of people living with lysosomal storage disorders,” said John Reed, global head of research and development at Sanofi.

“In parallel, we set out to evaluate venglustat in autosomal dominant polycystic kidney disease, a leading cause of kidney transplant. This outcome is not what we hoped for, especially for these patients. However, our research has furthered the scientific understanding of ADPKD by demonstrating that modulating the GSL pathway is insufficient to restore kidney function in adults affected by this disease,” he added.

Sanofi has completed studies and also has additional active studies currently evaluating venglustat in Gaucher disease type 3, Fabry disease and GM2 Gangliosidosis, which are all lysosomal storage disease caused by inherited genetic abnormalities.

http://www.pharmatimes.com/news/sanofi_halts_venglustat_clinical_programme_in_adpkd_1370973

Monday, May 31, 2021

India’s Serum Institute to raise AstraZeneca COVID-19 vaccine output in June

 The Serum institute of India will raise production of the AstraZeneca COVID-19 vaccine to about 90 million doses in June from about 65 million a month now, a company spokesman told Reuters on Monday.

https://whbl.com/2021/05/30/indias-serum-institute-to-raise-astrazeneca-covid-19-vaccine-output-in-june/

China reports first human case of H10N3 bird flu

 A 41-year-old man in China's eastern province of Jiangsu has been confirmed as the first human case of infection with the H10N3 strain of bird flu, China's National Health Commission (NHC) said on Tuesday.

The man, a resident of the city of Zhenjiang, was hospitalised on April 28 after developing a fever and other symptoms, the NHC said in a statement.

He was diagnosed as having the H10N3 avian influenza virus on May 28, it said, but did not give details on how the man had been infected with the virus.

H10N3 is a low pathogenic, or relatively less severe, strain of the virus in poultry and the risk of it spreading on a large scale was very low, the NHC added.

The man was stable and ready to be discharged from hospital. Medical observation of his close contacts had not found any other cases.

Many different strains of avian influenza are present in China and some sporadically infect people, usually those working with poultry. There have been no significant numbers of human infections with bird flu since the H7N9 strain killed around 300 people during 2016-2017.

No other cases of human infection with H10N3 have previously been reported globally, the NHC said.

As Japan Loses Training Camps, Olympics Buzz Fades

 Ahead of the Tokyo 2020 Olympics, the Japanese city of Kamo spent 70 million yen ($640,000) on horizontal bars, gymnastic mats and other upgrades to training facilities for 42 Russian gymnasts and coaches who now won't be coming.

The team scrapped plans for pre-Olympics training in Japan because of the resurgent COVID-19 pandemic, local officials said. Officials in the northwestern city of 25,000 say they regret the lost opportunity to host the team, even more than the money spent.

The Games, now less than eight weeks away after being delayed by a year, have been upended by COVID-19. Foreign spectators will not be allowed, and more than 100 municipalities have cancelled plans to host overseas teams.

"Local kids who could be future star gymnasts were disappointed to miss the opportunity to meet the Russian gymnasts," Kamo official Hirokazu Suzuki told Reuters.

Although there is little Olympic buzz in host city Tokyo, which is under a state of emergency because of the pandemic, in smaller places like Kamo, which had been planning the camp since 2019, the disappointment is perhaps more palpable.

Most of the cancellations so far have been in the 500 or so municipalities involved in the Olympics "host town" programme, in which foreign teams base their pre-Games training in Japanese facilities.

In some cases, such as Australia's judo team, the teams pulled out over safety concerns. In others, such as a delegation from Cuba set to stay in Higashimatsuyama city north of Tokyo, the municipalities decided not to host.

Organisers say the Games will be held safely. Several opinion polls have shown most Japanese people want the event to be cancelled or postponed again.

The national government earmarked 13 billion yen for municipalities to host training camps while imposing coronavirus measures, officials said.

Municipalities apart from Tokyo were expected to see a boost of about $110 billion through 2030 from the Games, the Tokyo Metropolitan Government said in a March 2017 estimate.

"Training camps will give a huge impulse to the economies of towns and cities where they are held, but that is being lost," said Katsuhiro Miyamoto, an emeritus professor of economics at Kansai University who studies the economic impact of the Olympics.

SPORTS EXCHANGE

Officials in Narita, east of Tokyo, were caught by surprise when the United States' track and field team informed them it had decided to pull out of planned a training camp.

About 120 athletes and staff, including star sprinter Justin Gatlin, were set to come for the camp, said Kentaro Abe, a municipal official in charge of host town projects.

Narita's sports relationship with the United States started in 2015, when it hosted the U.S. training camp before the world athletics championships in Beijing.

"It doesn't mean that our efforts to promote sport exchange between Japan and the United States came to nothing," Abe told Reuters, adding that city would look to continue the relationship.

In the central city of Toyota, home to the carmaker and Olympic sponsor Toyota Motor Corp, Canadian swimmers and coaches pulled out of pre-Olympics training scheduled to be held over about three weeks in July.

Such cancellations could add to the pain for towns and regions that are already smarting from a drop-off in tourism.

At her hotel in western Izumisano city, Eriko Tsujino worries she could lose about 60 bookings from Mongolian and Ugandan national teams if the athletes ditch plans to train in Japan.

"If they were to cancel at the last minute, it would cause a huge loss," she told Reuters, saying the bookings had still not been confirmed because of the state of emergency.

After the Russians cancelled their camp in Kamo, officials there decided at the last minute to host a much smaller Portuguese delegation of one female artistic gymnast and two accompanying staff, Suzuki said.

But the city also sought to keep friendly relations with the Russian gymnasts, asking kids and other locals to show them support with making video messages and letters.

https://www.usnews.com/news/top-news/articles/2021-06-01/as-japan-loses-training-camps-olympics-buzz-fades