Ironwood Pharmaceuticals, Inc. (NASDAQ: IRWD), a commercial biotechnology company, announced that the company will present clinical and preclinical data for the company’s soluble guanylate cyclase (sGC) stimulator praliciguat (IW-1973) during the American Diabetes Association’s (ADA) 78th Scientific Sessions in Orlando, Fla., June 22 through June 26, 2018. Praliciguat is currently being studied in Phase II clinical trials in patients with diabetic nephropathy and in patients with heart failure with preserved ejection fraction (HFpEF) (see also Ironwood Pharmaceuticals Inc.).
Data from a Phase IIa 14-day study of praliciguat in patients with diabetes and hypertension will be featured as an oral presentation during the Emerging Targets for Diabetes Treatment session, presented by John P. Hanrahan, M.D., M.P.H., of Ironwood. In addition, a Phase IIa rapid dose escalation study of praliciguat in patients with diabetes and hypertension will be presented during a poster session. Finally, new data will be presented in a moderated poster discussion on praliciguat’s effect on glucose tolerance, insulin sensitivity and triglycerides in a preclinical diet-induced obesity model.
sGC plays an important role in regulating many critical physiological processes; therefore dysregulation of sGC may play a role in multiple serious diseases. Ironwood’s sGC stimulators, including praliciguat, are believed to harness the nitric oxide/sGC/cyclic guanosine monophosphate (NO/sGC/cGMP) pathway by working synergistically with NO to improve blood flow and metabolism and decrease inflammation and fibrosis. Praliciguat has the potential to address the underlying causes of devastating diseases such as diabetic nephropathy and HFpEF by improving NO signaling, which may improve vascular and metabolic function and decrease the inflammatory and fibrotic consequences associated with these diseases.
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