Medtronic’s ITB therapy for post-stroke spasticity shows positive results

Medtronic announced the online publication of results, secondary endpoints of the ‘Spasticity In Stroke-Randomised Study’, or SISTERS, trial, demonstrate Intrathecal Baclofen Therapy. or ITB Therapy, with Lioresal Intrathecal injection reduces spasticity-related pain and improves quality of life more than conventional medical management with oral antispastic medications. Spasticity, a condition where certain muscles are constantly being contracted, is a relatively common long-term complication of stroke. Results of the study show ITB was more effective than CMM over six months for actual and least spasticity-related pain. Further, a majority of ITB patients reported satisfaction with spasticity reduction at month 6. More patients reported adverse events in the ITB group – 24/25 patients, 96% – compared to CMM – 63 percent; 77 events -, although events were generally consistent with the known safety profile of ITB Therapy. No patient discontinued ITB Therapy due to treatment related adverse events.

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