Aslan says varlitinib pre-clinical data published online in Cancers

Aslan Pharmaceuticals announced that new pre-clinical data on varlitinib’s activity in triple negative breast cancer, or TNBC, cell lines have been published online in Cancers, a peer-reviewed oncology journal. The data suggest that HER-family signalling plays an important role in TNBC progression and that pan-HER inhibition is potentially an effective treatment for TNBC patients. The article titled “Varlitinib Downregulates HER/ERK Signaling and Induces Apoptosis in Triple Negative Breast Cancer Cells” details the findings of the pre-clinical study in which investigators evaluated the efficacy of varlitinib, a reversible small molecule pan-HER inhibitor, in TNBC. In addition to data previously presented at the American Association for Cancer Research in 2017, the data show that varlitinib inhibited cell proliferation of three further TNBC cell lines.
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