Gilead Gets Canada OK for YESCARTA for Large B-cell Lymphoma

Gilead Sciences Canada, Inc. announced today that Health Canada has granted a Notice of Compliance (NOC) for Yescarta™ (axicabtagene ciloleucel), a new chimeric antigen receptor T (CAR T) cell therapy for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, primary mediastinal large B-cell lymphoma, high grade B-cell lymphoma, and DLBCL arising from follicular lymphoma (transformed follicular lymphoma, or TFL).¹ YESCARTA is not indicated for the treatment of patients with primary central nervous system lymphoma.

YESCARTA is a CAR T cell therapy, also known as a form of immunotherapy, that is custom-made for each patient from his or her own T cells – a type of white blood cell that is part of the immune system and that recognizes and kills foreign cells. The process works by removing the patient’s T cells and genetically altering them with chimeric antigen receptors (CARs). Once reinfused into the patient, the CAR T cells are able to find and attack cancer cells that normal T cells cannot detect.

This cell therapy induces complete response (no detectable cancer) in a proportion of patients with relapsed or refractory DLBCL and primary mediastinal large B-cell lymphoma, which are aggressive forms of non-Hodgkin lymphoma (NHL).

https://www.biospace.com/article/releases/gilead-receives-approval-in-canada-for-yescarta-and-8482-axicabtagene-ciloleucel-car-t-therapy-for-adults-with-relapsed-or-refractory-large-b-cell-lymphoma-after-two-or-more-lines-of-systemic-therapy/