Immunomedics, Inc., (NASDAQ: IMMU) (“Immunomedics” or the “Company”), a leading biopharmaceutical company in the area of antibody-drug conjugates (ADC), today announced that updated data from the Phase 2 study of sacituzumab govitecan in patients with metastatic triple-negative breast cancer (mTNBC) were published on NEJM.org as part of the February 21 print issue of the New England Journal of Medicine (NEJM).
“Patients with mTNBC have an aggressive tumor biology, and effective treatment options for previously treated patients are limited. Standard chemotherapy is associated with low responses and considerable toxicity, highlighting clinical need for better therapies,” commented Aditya Bardia, MD, MPH, lead author of the article and Director of Precision Medicine, Center for Breast Cancer, and attending physician at Massachusetts General Cancer Center, Harvard Medical School, Boston, MA. “This publication highlights a potential novel approach to treat mTNBC and improve patient outcomes, thereby creating a new treatment paradigm.”
Data from the NEJM paper showed that treatment with sacituzumab govitecan resulted in:
- An overall response rate of 33.3 percent (95% confidence interval [CI], 24.6 to 43.1) based on local assessment and 34.3 percent (95% CI, 25.4 to 44.0) based on blinded independent central review (BICR);
- A median duration of response of 7.7 months (95% CI, 4.9 to 10.8) (local assessment) and 9.1 months (95% CI, 4.6 to 11.3) (BICR);
- A median progression-free survival of 5.5 months (95% CI, 4.1 to 6.3).
Efficacy was observed in patients who had received prior taxanes and anthracyclines, suggesting a lack of cross-resistance to previous cytotoxic chemotherapy. Treatment duration with sacituzumab govitecan (5.1 months) was longer than with the immediate prior anti-tumor therapy (2.5 months), providing further evidence of clinical activity in patients with difficult-to-treat mTNBC.
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