Rafael Pharmaceuticals, Inc. (‘Rafael’ or the ‘Company’), a leader in the growing field of cancer metabolism-based therapeutics, today announced that devimistat will be investigated in a new combination for the treatment of T-Cell Lymphoma under the ‘Tailoring CAR-based immunotherapy strategies to T-Cell Lymphoma’ project as a part of Stand Up To Cancer’s T-Cell Lymphoma Dream Team Research Grant.
In addition to studying the new drug combination, investigators will perform sophisticated genetic tests to determine potential responders to the drug and whether this combination may be used prior to chimeric antigen receptor therapy (CAR-T) under the direction of Dr. Wei Zhang and Dr. Timothy Pardee.
According to Dr. Zanetta Lamar, a lymphoma specialist and an investigator on the grant, ‘We must develop better treatments for those with T-Cell Lymphomas. Although treatments are available, many patients who achieve remission will, unfortunately, experience a relapse. In addition, there is no consensus treatment for patients with this recurrent and difficult to treat disease.’ She added that this new combination therapy of devimistat is a unique way to treat cancer and does not have some of the common chemotherapeutic side effects such as hair loss.
Sanjeev Luther, President and Chief Executive Officer of Rafael Pharmaceuticals, commented, ‘Our motto, ‘To Save A Life Is To Save A Universe,’ illustrates our desire to develop potential treatments for patients with significant unmet clinical need. Research under this grant will explore devimistat in a new combination for T-Cell Lymphoma, and we believe this will help in identifying new therapeutic options.’
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