Biogen: Spinraza treatment improves motor functions, benefits SMA patients

Biogen announced that data from CS2/CS12, an open-label study of the safety and tolerability of SPINRAZA in individuals with later-onset spinal muscular atrophy, SMA, were published in the peer-reviewed journal Neurology, the medical journal of the American Academy of Neurology. The data show that individuals with later-onset SMA, treated with SPINRAZA, regained motor function that had been previously lost and that treatment stabilized their disease activity leading to improvements in activities of daily living. “These data give us new insight on how long-term treatment with SPINRAZA, over approximately three years, continues to help individuals with later-onset SMA and shows improved clinical efficacy,” said Basil Darras, M.D., lead study author, professor of neurology at Harvard Medical School. “A longitudinal analysis of this kind, which has not been available until now, provides a wealth of information about the ability to help prevent motor function loss, regain function and safely treat individuals with later-onset SMA. As we change the paradigm of living with SMA, long-term studies of this kind will be essential to understanding the disease.” “These results add to the body of evidence of SPINRAZA as the foundation of care in SMA broadening its safety and efficacy profile. The data underscore the ability of the therapy to help improve the lives of people with SMA, including those with later-onset SMA, who without treatment typically experience a progressive decline in motor function,” said Wildon Farwell, M.D., executive medical director, clinical development at Biogen.

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