Jocelyn Dupuis, Martin G. Sirois, Eric Rhéaume, Quang T. Nguyen, Marie-Élaine Clavet-Lanthier, Geneviève Brand, Téodora Mihalache-Avram, Gabriel Théberge-Julien, Daniel Charpentier, David Rhainds, Paul-Éduard Neagoe, Jean-Claude Tardif
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Declarations:
Declarations
- This study involved the use of non-human vertebrates.
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The author has confirmed that all appropriate ethical guidelines for the handling and use of animals in research have been followed and details of the oversight board have been included in the text.
- The author has confirmed that a statement listing potential conflicts of interest or lack thereof is included in the text.
Abstract
The acute respiratory distress syndrome (ARDS) is characterized by intense dysregulated inflammation leading to lung injury and respiratory failure. We studied the effects of colchicine pre-treatment on oleic acid-induced ARDS in rats. Colchicine reduced histological lung injury by 61%, reduced lung edema, and markedly improved blood oxygenation by increasing PaO2/FiO2 from 66 ± 13 mmHg (mean ± SEM) to 246 ± 45 mmHg. Lung neutrophil recruitment was reduced by colchicine with evidence for reduced neutrophils activation, as assessed by flow cytometry. This study strongly supports the clinical development of colchicine, a widely available low-cost drug, for the prevention of ARDS in conditions causing acute lung injury.
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