Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19

 

• Yahya Sohrabi
• Holger Reinecke
•  Rinesh Godfrey
•     

DOI:https://doi.org/10.1016/j.tem.2021.01.00  

PDF: https://www.cell.com/action/showPdf?pii=S1043-2760%2821%2900001-1

Recent data have revealed that fructose-rich diet triggers inflammation and lipid synthesis. Furthermore, lipid metabolism, cholesterol synthesis and sterol regulatory element binding protein-2 (SREBP-2) activation correlates with coronavirus disease 2019 (COVID-19)-induced cytokine storm. High fructose consumption result in SREBPs activation, altered cholesterol and lipid synthesis and may establish an innate immune memory in the cells, leading to severe COVID-19 in patients with obesity.

https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(21)00001-1