Therapeutic Solutions Develops Novel Stem Cell Therapy to Reduce Lung Scarring

  Therapeutic Solutions International, Inc., (OTC Markets: TSOI), announced today new data and patent filing demonstrating that the FDA cleared drug, lithium carbonate, substantially augments the scar inhibiting activity of its licensed JadiCell™ universal donor stem cell therapy. Furthermore, the data reveals that the JadiCell™ was superior to other stem cells at inhibiting development of lung scarring in the bleomycin model of pulmonary fibrosis.   

"After patients recover from COVID-19 approximately one-third of those who were hospitalized develop long-term scarring of the lung,1" said Dr. James Veltmeyer, Chief Medical Officer of the Company. "There are no known treatments for this condition, and in some cases its progression leads to continuous deterioration in lung function.  We are currently developing the JadiCell™ for treatment of acute lung failure.  The data disclosed today suggests the possibility of expanding the use of JadiCell™ to address post-COVID lung failure, a condition which appears to be rising exponentially."

The use of JadiCells for treatment of lung pathology and COVID-19 is exclusively licensed and owned by Therapeutic Solutions International.  In an FDA double blind, placebo controlled clinical trial the JadiCell™ was successful at substantially improving survival in end-stage patients with COVID-19 associated acute lung failure2.  Specifically, treatment was associated with significantly improved patient survival (91% vs 42%, P = .015), Serious Adverse Event-free survival (P = .008), and time to recovery (P = .03).  The Company plans to initiate a phase III pivotal registration trial and seek marketing approval for use of JadiCell in acute respiratory distress syndrome (ARDS) and other lung diseases.

"There are at least 660,000 patients suffering from post-COVID lung fibrosis if you look at the CDC statistics reporting over 2,000,000 COVID-19 related hospitalizations,3" stated Famela Ramos, Vice President of Business Development for the Company. "To our knowledge Therapeutic Solutions International is the only Clinical Stage Cell Therapy company aggressively addressing not only the acute lung failure associated with COVID-19, but also its long-term consequences."

https://www.prnewswire.com/news-releases/therapeutic-solutions-international-develops-novel-stem-cell-based-therapy-to-reduce-lung-scarring-potential-solution-to-post-covid-19-lung-deterioration-301296796.html