Variants of concern overrepresented in post-vaccination breakthroughs of SARS-CoV-2 in Wash. State

 Abbye E McEwen, Seth Cohen, Chloe Bryson-Cahn, Catherine Liu, Steven A Pergam, John Lynch, Adrienne Schippers, Kathy Strand, Estella Whimbey, Nandita S Mani, Allison J Zellikoff, Vanessa A Makarewicz, Elizabeth R Brown, Shah A Mohamed Bakhash, Noah R Baker, Jared Castor, Robert J Livingston, Meei-Li Huang, Keith R Jerome, Alexander L Greninger,  

View ORCID ProfilePavitra Roychoudhury

doi: https://doi.org/10.1101/2021.05.23.21257679

This article is a preprint and has not been certified by peer review [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.

PDF: https://www.medrxiv.org/content/10.1101/2021.05.23.21257679v1.full.pdf

Abstract

Across 20 vaccine breakthrough cases detected at our institution, all 20 (100%) infections were due to variants of concern (VOC) and had a median Ct of 20.2 (IQR=17.1-23.3). When compared to 5174 contemporaneous samples sequenced in our laboratory, VOC were significantly enriched among breakthrough infections (p < .05).

Competing Interest Statement

A.L.G. reports contract testing from Abbott Laboratories and research support from Gilead and Merck, outside of the described work.

Funding Statement

This work is supported by the National Institutes of Health [ORIP grant S10OD028685 to Scientific Computing at Fred Hutch, and UW-Fred Hutch CFAR AI027757 to P.R.].

https://www.medrxiv.org/content/10.1101/2021.05.23.21257679v1