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Wednesday, July 28, 2021

Arena In-Licenses Aristea Product For Immune-Mediated Inflammatory Diseases

 

  • Arena Pharmaceuticals Inc (NASDAQ: ARNA) and Aristea Therapeutics Inc have collaborated to develop RIST4721 for palmoplantar pustulosis (PPP) and other neutrophil-mediated diseases.

  • RIST4721 is an oral CXCR2 antagonist being developed by Aristea.

  • Under the terms of the agreement, Arena will pay upfront $60 million to Aristea and make a $10 million equity investment in Aristea's Series B financing.

  • In return, Aristea has granted Arena an exclusive option to acquire Aristea, including rights to all CXCR2 programs, upon completing the Phase 2b study of RIST4721 in PPP.

  • The agreement also provides a framework during the option period for the companies to jointly explore the development of other neutrophil-mediated diseases, including hidradenitis suppurativa (HS) and inflammatory bowel disease (IBD), potentially generating multiple data readouts during the option period.

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