"We continue to gather highly encouraging data from our next-generation, self-amplifying mRNA vaccine candidates ARCT-154 and ARCT-165 that have now both demonstrated encouraging neutralizing antibody concentrations against a broad range of variants upon boosting," said Joseph Payne, President and CEO of Arcturus Therapeutics. "We believe the STARR™ self-amplifying mRNA technology is an ideal platform that could address the ongoing need for updated booster vaccines at substantially lower dose levels, not just for COVID-19, but also for other infectious diseases."
In the ARCT-154 and ARCT-165 arms of the booster cohort of the ongoing Phase 1/2 study being conducted in the U.S. and Singapore, 24 participants divided into two equal groups of 12 received 5 micrograms of ARCT-154 or ARCT-165 following primary vaccination with Comirnaty® at least 5 months earlier. All participants were below 65 years of age at the time of receiving the booster dose. Figures 1 and 2 show the Day 15 and Day 29 post-boost results from validated pseudovirus microneutralization (MNT) and exploratory surrogate virus neutralization (sVNT) assays, respectively, performed with sera from the participants in the ARCT-154 and ARCT-165 groups.
https://finance.yahoo.com/news/arcturus-therapeutics-updates-data-arct-130000031.html
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