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Wednesday, January 19, 2022

Sanofi: Second positive Phase 3 Dupixent® (dupilumab) trial

 Second positive Phase 3 Dupixent® (dupilumab) trial confirms significant improvements for patients with prurigo nodularis

  • Dupixent is the first and only medicine to demonstrate positive Phase 3 results in prurigo nodularis, confirming the potential benefit of targeting IL-4 and IL-13, central drivers of type 2 inflammation, to address itch and skin lesions

  • Data confirm results from first Phase 3 trial, with 60% of Dupixent patients meeting the primary endpoint of itch reduction compared to 18% of placebo at 24 weeks

  • Additionally, nearly three times as many Dupixent patients experienced reduced skin lesions

  • Data continue to support well-established safety profile of Dupixent

  • Data to be submitted to regulatory authorities starting in H1

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