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Tuesday, March 1, 2022

RedHill Upamostat Shows 100% Efficacy In Non-Hospitalized COVID-19 Patients

 RedHill Biopharma Ltd 

 (Get Free Alerts for RDHL) has announced topline results from the Phase 2 part of the Phase 2/3 study of RHB-107 (upamostat) in non-hospitalized symptomatic COVID-19 patients.

  • The study showed promising efficacy results delivering a 100% reduction in hospitalization due to COVID-19, with zero patients on RHB-107 hospitalized with COVID-19 compared to 15% on the placebo-controlled arm requiring hospitalization. 
  • Furthermore, the study showed an 87.8% reduction in reported new severe COVID-19 symptoms, with only one patient on RHB-107 (2.4%, 1/41) compared to 20% (4/20) of patients on the placebo-controlled arm experiencing new COVID-19 related severe symptoms.
  • The study met its primary outcome measure, demonstrating a favorable safety and tolerability profile of RHB-107.
  • RHB-107 is an orally-administered antiviral targeting human serine proteases that prepare the spike protein for viral entry into target cells. 

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