COVID-19 Recrudescence after Nirmatrelvir/Ritonavir Treatment

 Aaron F Carlin, Alex E Clark, Antoine Chaillon, Aaron F Garretson, William Bray, Magali Porrachia, AsherLev T Santos, Tariq M Rana, Davey M Smith

DOI:  https://doi.org/10.1093/cid/ciac496

PDF: https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciac496/44139162/ciac496.pdf

We isolated a SARS-CoV-2 BA.2 variant from a person with COVID-19 recrudescence after nirmatrelvir/ritonavir treatment. Antiviral sensitivity and neutralizing antibody testing were performed with both parental SARS-CoV-2 and multiple variants of concern. We found that neither NM resistance nor absence of neutralizing immunity were likely causes of the recrudescence.

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciac496/6611663