Novo Nordisk A/S's
hugely popular Weight-loss drug Wegovy has helped people achieve the goal of shedding weight, but many have discontinued it due to severe nausea and side effects.
According to the prescribing information, 44% of patients taking the weekly injection experienced nausea, and 30% experienced vomiting - the guidance for healthcare professionals approved by
The obesity market's growth potential has attracted attention from investors seeking improved weight-loss drugs with fewer side effects.
Several small biotech companies are developing alternative weight-loss drugs without the side effects of nausea.
Danish Antag Therapeutics told Reuters that the ballooning obesity market has improved its fundraising prospects, and it hopes to close a Series A funding round of €30 million by the end of 2023 to begin its Phase 1 study.
In May, another biotech company, Switzerland-based Aphaia Pharma, launched the Phase 2 trial of its daily glucose formulation, which is mixed with water. Phase 1 data showed that it curbs appetite by restoring the natural release of GLP-1 and other hormones without causing nausea.
Novo Nordisk, Eli Lilly And Co
, and other major pharmaceutical companies are also working on developing second-generation weight-loss drugs. However, these drugs, like GLP-1s, still cause nausea based on recent trial data.
The interest in the obesity market could significantly increase the number of biotech firms working in this area in the coming years.
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