Regulus Positive Top Line in Phase 1b for Autosomal Dominant Polycystic Kidney Disease

 Mechanistic dose response observed at a 2mg/kg dose level based on urinary biomarker analyses

Encouraging exploratory results of imaging-based biomarkers with greatest reductions in total kidney volume seen in patients with the highest increases in PC1 and PC2

Cohort 3 fully enrolled with data readout anticipated in mid-2024; Cohort 4 screening to start in 2Q 2024

Company to hold conference call at 8:30am ET today

More information about the MAD clinical trial is available at clinicaltrials.gov (NCT05521191).

The Company will host a conference call and live audio webcast on March 12, 2024, at 8:30 am Eastern Time. To access the call, please dial (833) 816-1394 (domestic) or (855) 669-9657 (international). The live webcast can be found under "Events and Presentations" through the investor relations section of the Company's website. To access the telephone replay of the call, dial (877) 344-7529 (domestic) or (412) 317-0088 (international), passcode ID 6852735.  The webcast and telephone replay will be archived on the Company's website at www.regulusrx.com following the call.

https://www.prnewswire.com/news-releases/regulus-therapeutics-announces-positive-topline-data-from-the-second-cohort-of-patients-in-its-phase-1b-multiple-ascending-dose-mad-clinical-trial-of-rgls8429-for-the-treatment-of-autosomal-dominant-polycystic-kidney-disease-ad-302086081.html