Immuneering Positive Data Update on 3 Pancreatic Cancer Arms of Ongoing Phase 2a

 - Updated data for IMM-1-104 in combination with modified gemcitabine/nab-paclitaxel (mGnP) in first-line pancreatic cancer patients show favorable overall response rate (ORR = 43%) and disease control rate (DCR = 86%); planning for pivotal trial underway -

- Favorable initial data for IMM-1-104 in combination with modified FOLFIRINOX (mFFX) in first-line pancreatic cancer patients show target lesion shrinkage in all evaluable patients, including a 100% reduction (PR) -

- Encouraging initial data for IMM-1-104 monotherapy in second-line pancreatic cancer, including a 67% reduction (PR), demonstrate activity and support development in first-line combinations; over 75 patients enrolled across all three Phase 2a pancreatic arms -

- Continued highly differentiated tolerability profile observed for IMM-1-104;
approved MEK inhibitors currently drive ~$2.4 billion in sales -

- Further IMM-1-104 Phase 2a data expected in 2Q’25; additional combination arms planned to be initiated in 2025 -

- Company to hold webcast today at 8.30 am ET /5:30 am PT -

Immuneering will host a conference call and live webcast at 8:30 a.m. ET / 5:30 a.m. PT on January 7, 2025, to discuss the data and provide a business update. Individuals interested in listening to the live conference call may do so by dialing (800) 715-9871 for U.S callers and (646) 307-1963 for other locations and reference conference ID 4497245, or from the webcast link in the “investors” section of the company's website at www.immuneering.com A webcast replay will be available in the investor relations section on the company’s website for 90 days following the completion of the call.

https://www.globenewswire.com/news-release/2025/01/07/3005238/0/en/Immuneering-Announces-Positive-Data-Update-from-Three-Pancreatic-Cancer-Arms-of-Ongoing-Phase-2a-Trial-of-IMM-1-104-Plans-to-Expand-Trial-with-Additional-Arms.html