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Thursday, February 13, 2025

IDEAYA, Gilead Plan More Collaboration on Trodelvy, IDE397 in Lung Cancer

 

  • Entered into an additional clinical study collaboration and supply agreement with Gilead to evaluate IDE397, IDEAYA's MAT2A inhibitor, in combination with Trodelvy, Gilead's Trop-2 directed ADC, in MTAP-deletion NSCLC
  • The potential first-in-class clinical combination of IDE397 and Trodelvy targets two mechanistically distinct and complementary nodes of MTAP-deletion in solid tumors
  • MTAP-deletion prevalence in NSCLC is estimated to be approximately 15%

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