Mineralys Therapeutics' blood pressure drug meets goal in trials

 – Launch-HTN met its primary endpoint with lorundrostat 50 mg dose achieving a 16.9 mmHg reduction in systolic blood pressure, and a 9.1 mmHg placebo-adjusted reduction (p-value < 0.0001) assessed by automated office blood pressure at week 6 –

– Launch-HTN met a predefined endpoint with lorundrostat 50 mg dose achieving a 19.0 mmHg reduction in systolic blood pressure, and an 11.7 mmHg placebo-adjusted reduction (p-value < 0.0001) assessed by automated office blood pressure at end of treatment, week 12 –

– Advance-HTN met its primary endpoint with lorundrostat 50 mg dose achieving a highly statistically significant 7.9 mmHg placebo-adjusted reduction assessed by 24hr ABPM at end of treatment, week 12 –

– Lorundrostat demonstrated a favorable safety and tolerability profile in both pivotal trials –

– Full results from Advance-HTN to be presented on March 29, 2025, at the American College of Cardiology Scientific Sessions –

– Conference call today at 8:00 a.m. ET –

The Company’s management team will host a conference call today, March 10, 2025, at 8:00 a.m. ET. To access the call, please dial 1-877-704-4453 in the U.S. or 1-201-389-0920 outside the U.S. A live webcast of the conference call may be found here. A replay of the call will be available on the “News & Events” page in the Investor Relations section of the Mineralys Therapeutics website (click here).

https://www.globenewswire.com/news-release/2025/03/10/3039559/0/en/Mineralys-Therapeutics-Announces-Positive-Topline-Results-from-Launch-HTN-and-Advance-HTN-Pivotal-Trials-of-Lorundrostat-for-the-Treatment-of-Uncontrolled-or-Resistant-Hypertension.html#:~:text=%E2%80%9CThe%20positive%20results%20and%20clinically,the%20United%20States%2C%E2%80%9D%20stated%20Jon