Risks of postural orthostatic tachycardia syndrome after COVID-19 vaccination, SARS-Cov-2 Infection

 

• Alan C. Kwan, 
• Joseph E. Ebinger, 
• Janet Wei, 
• Catherine N. Le, 
• Jillian R. Oft, 
• Rachel Zabner, 
• Debbie Teodorescu, 
• Patrick G. Botting, 
• Jesse Navarrette, 
• David Ouyang, 
• Matthew Driver, 
• Brian Claggett, 
• Brittany N. Weber, 
• Peng-Sheng Chen & 
• Susan Cheng 
  
  

  Abstract

  Postural orthostatic tachycardia syndrome (POTS) was previously described after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, limited data are available on the relation of POTS with Coronavirus Disease 2019 (COVID-19) vaccination. Here we show, in a cohort of 284,592 COVID-19-vaccinated individuals, using a sequence–symmetry analysis, that the odds of POTS are higher 90 days after vaccine exposure than 90 days before exposure; we also show that the odds for POTS are higher than referent conventional primary care diagnoses but lower than the odds of new POTS diagnosis after SARS-CoV-2 infection. Our results identify a possible association between COVID-19 vaccination and incidence of POTS. Notwithstanding the probable low incidence of POTS after COVID-19 vaccination, particularly when compared to SARS-Cov-2 post-infection odds, our results suggest that further studies are needed to investigate the incidence and etiology of POTS occurring after COVID-19 vaccination.
  
  https://www.nature.com/articles/s44161-022-00177-8