Kymera Positive Results from Phase 1 Healthy Volunteer Trial of Oral STAT6 Degrader

Kymera Therapeutics announced positive Phase 1 results for KT-621, their first-in-class oral STAT6 degrader medicine. The trial demonstrated >90% STAT6 degradation in blood at doses above 1.5mg and complete degradation in both blood and skin at MAD doses ≥50mg. The drug showed impressive efficacy with TARC reduction up to 37% and Eotaxin-3 reduction up to 63%, comparable or superior to dupilumab. KT-621 exhibited excellent safety with no serious adverse events and a profile undifferentiated from placebo. The Phase 1 study included 118 healthy volunteers across single and multiple ascending dose cohorts. The company plans to advance KT-621 through their ongoing BroADen Phase 1b trial in atopic dermatitis patients, with data expected in Q4 2025, followed by Phase 2b trials in AD and asthma starting in Q4 2025 and Q1 2026 respectively.

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