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Friday, January 3, 2020

Managed care providers could see healthy 2020 on repeal of insurance tax

Goldman’s Stephen Tanal and JPMorgan’s Gary Taylor are bullish on Humana’s (NYSE:HUM) growth prospects on the basis of the expected permanent repeal of the health insurance tax (HIT) associated with the Affordable Care Act (ACA). Mr. Tanal has raised his price target to $425 (17% upside) from $397 and raised in non-GAAP EPS target ~10% to $24.10. Mr. Taylor has raised his price target to $448 from $437 and maintains his “Top Pick” tag on the stock.
The tax on providers, enacted by the Obama administration, was intended to subsidize the cost of insurance for uninsured families and individuals. Companies have been lobbying to kill the tax for years since they have had to absorb part of the expense in order to remain competitive in the Medicare Advantage market.
In its year-end spending deal, Congress appears ready to do just that (the House passed the package on Tuesday, December 31). If the Senate goes along, a virtual certainty, the tax would be repealed in 2021.
In 2018, UnitedHealth Group (NYSE:UNH) paid $2.60B, the highest HIT tab, followed by Anthem (NYSE:ANTM) ($1.54B), Humana ($1.04B) and Centene (NYSE:CNC) ($709M).
Related tickers: Cigna (NYSE:CI), WellCare Health Plans (NYSE:WCG), Molina Healthcare (NYSE:MOH), CVS Health (NYSE:CVS).

End-of-year US drug approvals tied to more adverse events – study

Results from a new study showed that drugs approved near the end of the year in the U.S. are linked to more hospitalizations, life-threatening events and deaths, a rate about twice as high as medicines approved earlier in the year.
Investigators also found similar bumps at the end of each month, implying that the reviewers are “clearing their desks” at these timepoints. They found that 15% of all new drugs were OK’d in December, a rate 80% higher than the average month, although the FDA says only 12% of new molecular entities are approved in that month.
in the 1980s and 1990s, 40% of U.S. approvals occurred in December but the trend is more evenly distributed since PDUFA was approved in 1992.
Selected tickers: BIBTHWARKGBMEGRXIXJBISCHNAXLVIDNAGDNAKMEDXBIBMYPFEOTCQX:RHHBYMRKLLYABBVJNJAMGNBIIBGILDGSKAZNMYLBHCTEVA

Can-Fite up on encouraging Namodenoson data

Nano cap Can-Fite BioPharma (NYSEMKT:CANF) is up 25% premarket on average volume in response to encouraging preclinical data on Namodenoson (CF102).
Studies performed at Hadassah Medical Center in Jerusalem on fat mouse and diabetic rat models showed Namodenoson induced weight loss and normalized glucose levels.
The company has filed a patent application through the World Intellectual Property Organization for the use of Namodenoson as an anti-obesity drug.
Topline results from a Phase 2 study in patients with nonalcoholic fatty liver disease (NAFLD), with or without NASH, should be available this quarter.
A Phase 3 trial in certain liver cancer patients should launch soon.

Endo Pharma gains after Piper upgrade

“Broadly Maligning This Group No Longer Warranted,” goes the title of a note on specialty pharma from Piper Jaffray.
“Can a specialty pharma deep value idea really work in 2020,” asks the team. “We think so,” they answer themselves, upgrading Endo Pharmaceuticals (NASDAQ:ENDP) to Overweight, with $7 price target (56% upside).
Notable Calls notes this is the first upgrade for Endo in two years, and this “coiled spring” could see something nearing a $5 handle today.
Shares are higher by 2% premarket to $4.59

Applied Genetic Tech up ahead key data readouts

Applied Genetic Technologies (AGTC +0.5%) shrugs off broad market selling in early trade (albeit on very light volume). Shares have rallied 56% since December 18 ahead of two expected data readouts this month.
Interim six-month data from the expansion group in a Phase 1/2 study evaluating its recombinant adeno-associated virus vector (rAAV2tYF-GRK1-RPGR) in patients with X-linked retinitis pigmentosa caused by RPGR mutations.
Interim six-month dose-escalation data from Phase 1/2 studies evaluating gene therapy AGTC-402 in CNGA3 achromatopsia and CNGB3 achromatopsia (color blindness).
The company plans to present comprehensive data on all the trials at its R&D Day on Tuesday, January 28.

Leap Therapeutics up 60% on BeiGene deal

Leap Therapeutics (LPTX +59.5%) is up on a healthy 44x surge in volume after announcing an exclusive option and license agreement with BeiGene (NASDAQ:BGNE) for the development and commercialization of lead candidate DKN-01 in Asia (excluding Japan), Australia, and New Zealand. Leap will retain exclusive rights to DKN-01 for the rest of the world.
Under the terms of the agreement, Leap will receive $3M upfront and will receive an additional payment if BeiGene exercises its option to develop and commercialize DKN-01. If so, it will be eligible to receive up to $132M in milestones and tiered royalties on net sales.
BeiGene will also make a $5M equity investment in Leap as part a $27M equity deal with two institutional investors.
DKN-01 is a humanized IgG4 monoclonal antibody that binds to Dickkopf-1 (DKK1), a protein associated with a poor prognosis in a range of cancers. Specifically, it inhibits a pathway called canonical Wnt/Beta-catenin which plays a key role in embryonic development, cell proliferation and differentiation. The company says patients with confirmed Wnt pathway alterations experience a greater duration of clinical benefit from DKN-01.

Allergan settles Bystolic patent dispute with Ajanta

Allergan (AGN -0.4%) has settled patent infringement litigation with would-be generic competitor Maharashtra, India-based Ajanta Pharma Limited related to hypertension med Bystolic (nebivolol).
Ajanta will be prohibited from selling its generic version in the U.S. until the patent expires in December 2021 unless granted a non-exclusive license or the patent is invalidated.
Bystolic generated $431M in U.S. sales during the first three quarters of 2019.