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Wednesday, April 1, 2020

COVID-19-related actions – Healthcare

AbbVie (NYSE:ABBV) donates $35M to support COVID-19 relief efforts. Shares down 2% premarket.
Mallinckrodt (NYSE:MNK) and Novoteris, LLC announce that Health Canada has signed off on a pilot study evaluating inhaled nitric oxide therapy Thiolanox in COVID-19 patients at Vancouver Coastal Health Authority facilities. Recruitment should start in the next few days. Shares up 28% premarket.
CytoDyn (OTCQB:CYDY) has filed a second clinical trial protocol with the FDA to treat critically ill COVID-19 patients with leronlimab under the same IND as its recently launched Phase 2 study in patients with mild-to-moderate symptoms. Target enrollment is 342 subjects.
Centene (NYSE:CNC) will cover the costs of COVID-19-related treatments for Medicare, Medicaid and Marketplace members. It has also eliminated the need for providers to collect co-pays and authorization requirements for said treatment.
Henry Schein (NASDAQ:HSIC) will be the exclusive distributor of a second rapid point-of-care blood test for COVID-19 developed by privately held BioMedomics and available through Becton, Dickinson and Company (NYSE:BDX). HSIC up 2% premarket.
Flexion Therapeutics (NASDAQ:FLXN) has withdrawn its 2020 guidance and suspended its active clinical trials.
Aytu BioScience (NASDAQ:AYTU) has received a shipment of 100K rapid blood tests from the manufacturer. Relabeling is in process. Orders will be filled shortly thereafter. Shares up 13% premarket.
Diffusion Pharmaceuticals (NASDAQ:DFFN) will collaborate with the University of Virginia and the Integrated Translational Research Institute of Virginia to evaluate Trans Sodium Crocetinate in patients with COVID-19-associated acute respiratory syndrome. Shares up 54% premarket.
Citius Pharmaceuticals (NASDAQ:CTXR) inks an exclusive six-month option agreement with a subsidiary of Novellus for a stem cell therapy for acute respiratory distress syndrome. Shares up 48% premarket.
https://seekingalpha.com/news/3557101-covidminus-19-related-actions-healthcare

China starts to report asymptomatic coronavirus cases

Chinese health authorities began on Wednesday reporting on asymptomatic cases of the coronavirus as part of an effort to allay public fears that people could be spreading the virus without knowing they are infected with it.
China, where the coronavirus emerged late last year, has managed to bring its outbreak under control and is easing travel restrictions in virus hot spots.
But there are concerns that the end of lockdowns will see thousands of infectious people move back into daily life without knowing they carry the virus, because they have no symptoms and so have not been tested.
Up to now, the number of known asymptomatic cases has been classified, and it is not included in the official data, though the South China Morning Post newspaper, citing unpublished official documents, recently said it was more than 40,000.
In an effort to dispel public fears about hidden cases of the virus, the government has this week ordered health authorities to turn their attention to finding asymptomatic cases and releasing their data on them.
Health authorities in Liaoning province were the fist to do so on Wednesday, saying the province had 52 cases of people with the coronavirus who showed no symptoms as of March 31, they said in a statement on a provincial government website.
Hunan province said it had four such cases, all of them imported from abroad, it said in a statement on its website.
The National Health Commission is due to start reporting aggregate, national data on asymptomatic cases later on Wednesday.

There is debate among experts about how infectious asymptomatic cases are but the commission has said all cases would be centrally quarantined for 14 days.It said 1,541 people with asymptomatic coronavirus infections were under observation as of the end of Monday.
China has had more than 81,000 cases of the coronavirus and 3,305 deaths.
https://www.reuters.com/article/us-health-coronavirus-china-asymptomatic/china-starts-to-report-asymptomatic-coronavirus-cases-idUSKBN21J450

Fresenius Medical Care works with US dialysis providers to tackle coronavirus

Fresenius Medical Care (FMC) on Wednesday said it was working with other dialysis providers to provide care in isolation for people with kidney problems in the United States who are or may be infected with coronavirus.
FMC, the world’s largest kidney dialysis provider, said it was collaborating with DaVita Inc., U.S. Renal Care, American Renal Associates, Satellite Healthcare and others on making a national contingency plan to ensure patients who need dialysis can continue to receive care by creating isolation capacity that other providers can use.
“The companies are focused on ensuring there are enough nurses, social workers, dietitians, care technicians and available space to treat all dialysis patients, including those who are or may be infected with COVID-19, in a way that does not unnecessarily expose the hundreds of thousands of other patients who entrust them with their care,” FMC said.
https://www.reuters.com/article/us-health-coronavirus-fresenius-medical/fresenius-medical-care-working-with-dialysis-providers-in-u-s-to-tackle-coronavirus-idUSKBN21J4J8

India likely to soon ease some drug export curbs after U.S. pressure

India will likely relax some export restrictions on pharmaceutical products soon due to intense pressure from the United States which is worried about drug shortages as the number of coronavirus cases surge, two Indian government officials told Reuters.
India, which supplies more than a quarter of the world’s generic drugs, last month restricted exports of 26 pharmaceutical ingredients and the medicines made from them. The move was seen as an attempt to secure supplies for its domestic population after the outbreak played havoc with the industry’s supply chain globally.
The restrictions are not complete bans but impede sales of drug and drug ingredients overseas by specifying circumstances for their export and requiring firms to procure a “no objection” certificate from the government.
An easing of those restrictions will probably come within two days and will likely include Paracetamol, a common pain reliever also known as acetaminophen, the government officials in New Delhi said.
“There is so much (U.S.) pressure on the government. For U.S. what matters is Paracetamol, it matters to them significantly,” said one official, adding that India had adequate stock of the drug for domestic use for at least four months.
The restrictions will be lifted for all countries, the officials said, but it was not immediately clear exactly how many drugs formulations would be exempted.
Both officials declined to be identified due to the sensitive nature of the discussions. India’s commerce ministry did not immediately respond to a request for comment.
The U.S. government said in a statement on Tuesday that Secretary of State Mike Pompeo had spoken with India’s foreign minister and sought cooperation in strengthening global pharma manufacturing and supply chains, but gave no further details.
President Donald Trump has warned Americans of a “painful” two weeks ahead in fighting the virus. Nearly 3,900 people have died in the United States, and the total confirmed U.S. cases has risen to 187,000.
Imports from India accounted for 24% of medicines and 31% of medicine ingredients to the United States in 2018, according to the U.S. Food and Drug Administration.

India was, however, unlikely to ease a ban on the export of malaria drug hydroxychloroquine, which came in addition to the restrictions on the 26 drugs and formulations. The drug is being tested to see if it is effective in treating patients with COVID-19.
The United States’ Health and Human Services has listed hydroxychloroquine as a medical resource that was subject to hoarding prevention measures.
https://www.reuters.com/article/us-health-coronavirus-india-pharmaceutic/india-likely-to-soon-ease-some-drug-export-curbs-after-u-s-pressure-sources-idUSKBN21J4YN

Moscow unveils coronavirus tracking app as national lockdown widens

Authorities in Moscow unveiled a smartphone app designed to keep tabs on people who have been ordered to stay at home because of the coronavirus and Russia on Wednesday expanded its lockdown to cover more of its sprawling territory.
Russia’s official tally of coronavirus cases rose to 2,777 on Wednesday, a one-day increase of 440. Twenty-four people have so far died, authorities say.
Moscow, the epicentre of Russia’s outbreak, announced a partial lockdown on Sunday. Residents have been told they can only leave their home to buy food or medicine nearby, get urgent medical treatment, walk the dog or empty their bins.
A Moscow city official said that authorities had developed a smartphone app for residents who have contracted the virus to download that would allow them to be monitored.

The app is still in testing, the official, Eduard Lysenko told the Ekho Moskvy radio station.
Moscow is also preparing to roll out a city-wide QR-code system where each resident that registers online will be assigned a unique code that they can show to police officers if stopped when going to the shop or the chemist, the official said.
Eight southern Russian regions rolled out similar lockdown measures to Moscow on Wednesday, meaning that more than 60 of Russia’s more than 80 regions are now in a state of partial lockdown.
https://www.reuters.com/article/us-health-coronavirus-russia/moscow-unveils-coronavirus-tracking-app-as-national-lockdown-widens-idUSKBN21J4W8

Europe to launch coronavirus contact tracing app initiative

European scientists and technologists will launch a joint initiative on Wednesday to support the use of digital applications in the fight against coronavirus while complying with the region’s tough privacy laws.
The Pan-European Privacy Preserving Proximity Tracing (PEPP-PT) brings together 130 researchers from eight countries to develop applications that can support contact tracing efforts within countries and across borders.
These will become more important in containing future flare-ups in COVID-19, the flu-like illness caused by coronavirus, once country-wide lockdowns have succeeded in ‘flattening’ the curve of the pandemic’s spread.
“Our goal is to provide a backbone for the digital core components of the global fight against COVID 19,” said Hans-Christian Boos, founder of business automation company Arago and a member of a digital advisory council to the German government.
“The PEPP-PT platform others can build on includes an anonymous and privacy-preserving digital proximity tracing approach, which is in full compliance with GDPR and can also be used when traveling between countries.”
The GDPR, or General Data Protection Regulation, is the European Union’s privacy rulebook that sets strict limits on the processing of personal data, making it difficult, for example, to use smartphone location data to fight COVID-19.
A more promising route is to track connections made between people’s smartphones using Bluetooth, a communications technology where ‘handshakes’ between devices can be logged and used to alert those who have come into close proximity with someone who tests positive.
That is the approach behind the TraceTogether app launched by Singapore to support its so-far successful public health response to coronavirus that has kept COVID-19 infections in the hundreds.
More than 851,000 people worldwide have contracted COVID-19 with 42,053 dying from it, according to a Reuters tally on Wednesday. Italy has been hardest hit, with 12,428 fatalities.

UK PLANS

Britain, which has left the European Union, was poised to launch its own digital contact tracing initiative, according to reports.
The UK contact tracking app, which will operate on an opt-in basis, would be released either just before or just after a lockdown is lifted, Sky News reported here on Monday, citing several people with close knowledge of the project.
Even if Britain does go it alone, its researchers – including from the Oxford Big Data Institute – have made a major contribution towards assessing the potential value of digital contact tracing to keep a lid on coronavirus.
Boos will hold a news briefing at 11 am (0900 GMT) together with Marcel Salathe, head of the Digital Epidemiology Lab at the Swiss Federal Institute of Technology in Lausanne, who has cited the Oxford research as a valuable guide.

Thomas Wiegand of the Technical University of Berlin and head of the Fraunhofer Heinrich Hertz Institute (HHI) will also take part.
The HHI said on Monday that Germany was weeks away from lanching a smartphone app that could track close-proximity Bluetooth ‘handshakes’ between devices, making it possible to warn those at risk of infection.
German government sources say the app could be launched on or around April 16 as part of a series of steps to ease social restrictions.
https://www.reuters.com/article/us-health-coronavirus-europe-tech/europe-to-launch-coronavirus-contact-tracing-app-initiative-idUSKBN21J4HI

Mother of invention: the new gadgets dreamt up to fight coronavirus

Driving to work at his factory to the west of London last week, designer Steve Brooks had coronavirus on his mind. What could he make that would let him open a door without touching the handle?
“Everyone has to use their little finger or find the bit of the door that nobody’s touched,” said the designer and owner at DDB Ltd, a company which makes office furniture. So he produced a hook to do the job.
The so-called hygienehook is small enough to fit in a pocket and made from a non-porous material, which makes it easy to clean. It is one of hundreds of gadgets dreamt up in recent days and weeks to help prevent people from spreading the coronavirus.
From furniture makers to AI software developers, companies around the world are adapting existing products or inventing new ones to help fight the pandemic or just make life easier for those working from home, in hospitals or stuck in quarantine.
The flurry of innovation comes as companies from Ford (F.N) and Airbus (AIR.PA) to luxury goods giant LVMH (LVMH.PA) retool plants to make critical equipment like hand sanitizers, ventilators and masks.
In years gone by it was large companies like these, with the financial clout and factories, who typically had to be relied upon to move rapidly from designing a prototype to manufacturing the product.
A crucial difference now, though, is that 3D printing and high-tech software mean devices can be produced faster than ever by companies big and small.
“There is definitely a ton of people with 3D resources very willing to help,” said MacKenzie Brown, founder of California-based product design company CAD Crowd.
Two weeks ago, his company launched a month-long contest for practical devices for navigating the new coronavirus world.
About 65 entries have poured in, including a wrist-mounted disinfectant sprayer, half gloves for knuckle-pushing of buttons and a device that lets you open car doors without touching the handle, aimed at cab users.
As the pandemic makes people far more aware of hygiene, some new products may have a shelf life beyond the current crisis.

‘WE HAD THE ALGORITHM’

Startups are retooling their technology.
In Seattle, brothers Joseph and Matthew Toles and their friend Justin Ith, who own a young company called Slightly Robot, had developed a wristband after college aimed at reducing compulsive skin-picking, nail-biting, and hair-pulling.
When their home city reported its first fatalities from the virus last month, they adapted the design to create a new smartband, the Immutouch, which buzzes when the wearer’s hand goes near their face.
“We had the algorithm, we had the software and the hardware. We’ve repurposed it for face-touching,” Matthew Toles said in an interview. “We made 350 devices and a website in one week and now it’s how fast can we ramp up.”
Romanian robotic software company UiPath has meanwhile found a way for nurses in the Mater Misericordiae University Hospital in the Irish capital Dublin to ditch time-consuming data entry and automate filing of virus test results. It hopes to replicate it in other hospitals.
Scylla, a U.S.-based AI company that makes gun detection systems for schools and casinos, turned its sights on the virus when China, the original epicenter of the outbreak, reported its first cases three months ago.
It has re-deployed its AI analytics software to measure the temperature of a person’s forehead, sending out an alert if it detects a fever. Taking images from a thermal camera, the software can be used in public buildings like hospitals and airports, and corporate offices, chief technology officer Ara Ghazaryan said.
The government of a South American nation has placed an order for 5,000 licenses of Scylla’s system for its public buildings and transport system, Ghazaryan said. He declined to name the country.

WORLD WAR TWO INNOVATION

Global upheaval often spawns new products and innovation.
The current burst of creativity may eventually compare to that seen during World War Two when companies, governments and scientists embarked on projects that had lasting consequences.
Technology used to help guide rockets eventually led to the first satellites and putting men on the moon.
“There’s no question that inventors will be coming up with hundreds, if not thousands, of new ideas,” said Kane Kramer, inventor and co-founder of the British Inventor’s Society. He first conceived the idea of downloading music and data in the late 1970s.
“Everyone’s downed tools and are only picking them up to fight the virus. It’s a global war.”
Many companies are donating their new wares or selling them at cost price. The CAD Crowd contest designs are free for download and use, for example. For some, though, the extra business could provide a financial cushion as other sources of income evaporate during the pandemic.
DDB designer Brooks near London has worked quickly.
Less than a week after his first design, four different models of the hook went on sale this week, selling at just under 15 pounds ($18.60) each. He is donating one hook for every one he sells.
Now Brooks is turning his creative eye to another gadget along similar lines.
“We’ve already had a request from the National Health Service in Wales about designing something for pushing a door.”
https://www.reuters.com/article/us-health-coronavirus-invention-insight/mother-of-invention-the-new-gadgets-dreamt-up-to-fight-coronavirus-idUSKBN21J4BG