Low Hospitalization ,Death Rates in COVID-19 Patients Treated With Early Ambulatory, Supportive Care

 A Case Series and Observational Study

Author(s): Brian M. Tyson, George Fareed, Emmanuel Beltran Gutierrez, Robert Villegas, Edgar Josue Anaya Gomez, Paloma Serrano Lopez, Ernesto Breton Herrera, Miriam Arlet Gutierrez Castro, Jesus Palomera III, Christiany Alexandrah Morales, Ana Mariella Escutia Gonzalez, Fabiola Tyson, Mathew Crawford

Published: May 7, 2025

https://doi.org/10.71189/JIM/2025/V01N02A06

Abstract:

This study evaluates early ambulatory protocols for treating 4376 COVID-19 patients at All Valley Urgent Care (AVUC) facilities in Imperial County, California, and compares outcomes with other patients in the same region during a nearly identical period. The goal was to contribute to evidence on whether early outpatient treatment reduces hospitalization and mortality rates. The protocols, based on data from neighboring countries, included Protocol 1 (a multivitamin pack, selective use of hydroxychloroquine, two antibiotics, and inhaled steroids) and Protocol 2 (which added ivermectin). Results were stratified by disease severity at presentation. The average patient age was 40.5 years; 12.8% of patients were under 20 years old. For the 3962 mild COVID-19 patients treated early, no deaths occurred, compared to a 3.03% mortality rate (2.25% risk-adjusted) in the same county during the same period. Hospitalization rates for this group were 0.05%, compared to 22.68% (20.76% risk-adjusted) in the general population. When treated within 7 days, patients had a 100% success rate, while those treated later had a 99.9% success rate. Mild symptom patients had lower hospitalization (OR = 0.0293; P < .0001) and mortality (OR = 0.0000; P = .0008) rates. These results suggest the multidrug protocols significantly reduced adverse outcomes, with no serious side effects observed during follow-up (3–14 days).

https://journalofindependentmedicine.org/articles/v01n02a06/