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Tuesday, February 16, 2021

CVS Will Enter Individual Public Exchange Markets: CEO

 * CVS HEALTH CORP CEO SAYS CVS WILL ENTER INDIVIDUAL PUBLIC EXCHANGE MARKETS

* CVS HEALTH CORP SAYS Q1 2021 EXPECTED TO BE THE LOWEST EARNINGS QUARTER FOR THE YEAR

* CVS HEALTH CORP SAYS HAS CAPACITY TO ADMINISTER 20-25 MILLION COVID-19 VACCINES PER MONTH, DEPENDING ON SUPPLY

* CVS HEALTH CORP EXEC SAYS COVID-19 VACCINATION PROFITABILITY IN LINE WITH FLU SHOT

* CVS HEALTH CORP EXEC SAYS COVID-19 VACCINE SUPPLY TO OPEN UP IN BEGINNING IN APRIL

* CVS EXEC BELIEVES COMPANY COULD ADD MORE CUSTOMERS THROUGH COVID-19 VACCINE ADMINISTRATION

https://www.marketscreener.com/news/latest/CVS-Health-CEO-Says-CVS-Will-Enter-Individual-Public-Exchange-Markets--32452600/

Moderna Provides U.S. COVID-19 Vaccine Supply Update

 Company has supplied 45.4 million doses of Moderna COVID-19 Vaccine to U.S. Government to date

The CDC communicated that approximately 25.5 million doses of the Moderna COVID-19 Vaccine have been administered in the U.S.

Additional 33.2 million doses have been produced and are filled in vials and in the final stages of final production and testing before release

Moderna expects to deliver 100 million doses to the U.S. Government by end of March 2021

Moderna expects to deliver 100 million additional doses by end of May 2021 followed by another 100 million additional doses by end of July 2021

https://www.businesswire.com/news/home/20210216005775/en/Moderna-Provides-U.S.-COVID-19-Vaccine-Supply-Update

EU adds anti-variant clauses to new COVID vaccine supply deals

 The European Union is adding clauses to contracts with COVID-19 vaccine makers which would allow the bloc to gain access to possible upgraded shots that may offer better protection against variants of the virus, three EU sources said.

More contagious mutations are spreading fast in the EU and across the world, with the so-called British variant seen by experts as likely to become prevalent on the continent.

In new contracts with vaccine manufacturers, the EU is adding clauses that explicitly cover variants, three EU officials involved in talks with the companies told Reuters.

Vaccine makers are testing their shots against variants and are also working on tweaks that could make them more effective against virus mutations.

One official said the clauses would allow the EU not to buy vaccines that are not effective against widespread variants, and to order upgraded versions instead. However, the source said clauses were vague on the definition of variants and the actual legal power they would give the EU.

The three officials said that an anti-variant clause was included in a second contract finalised earlier in February with Pfizer and BioNTech for the supply of 300 million additional doses of their COVID-19 vaccine.

Pfizer and the European Commission did not immediately respond to requests for comment.

Studies have shown the Pfizer vaccine can be effective against the British and the South African variants. The company is also working on a booster shot that would be tailored against variants.

The EU now wants to add these clauses in new supply deals and is considering whether to upgrade its existing contracts, the officials said.

The bloc is negotiating new supply agreements with Novavax, Valneva and Moderna to increase its vaccine reserve beyond the nearly 2.3 billion doses which it has already secured from six pharmaceutical firms.

On Wednesday, the EU Commission will present a series of measures to boost the EU preparedness against variants, including new funds to help sequence the genome of the new coronavirus and spot variants.

Most EU countries have so far done little or no sequencing at all.

https://www.reuters.com/article/us-health-coronavirus-eu-variants/eu-adds-anti-variant-clauses-to-new-covid-vaccine-supply-deals-sources-idUSKBN2AG1L2

Cassava Sciences Target Raised to 'Street High' at Maxim

 Maxim Group analyst Jason McCarthy raised the price target on Cassava Sciences (NASDAQ: SAVA) to $80.00 (from $14.00) while maintaining a Buy rating after the company announced the first set of cognition and behavior data from the P2b extension study of simufilam in mild-moderate Alzheimer's disease (AD).

The analyst commented, "The space is shifting, and SAVA's simufilam is about as advanced as any asset in this new wave of AD therapeutics. The 6-month cog data was the start. The 9-month and 12-month cog data are next, as are two phase 3s (even one with a 6-month end point, unheard of in AD). We break it down below. We have lowered our discount rate to 20%, from 30%, and use a 70% risk adjustment (unchanged), which serves to increase our price target to $80, from $14."

https://www.streetinsider.com/Analyst+Comments/Cassava+Sciences+%28SAVA%29+PT+Raised+to+Street+High+%2480+at+Maxim+Group/17974637.html

bluebird bio Temporarily Suspends Studies of LentiGlobin Gene Therapy for Sickle Cell

 bluebird bio, Inc. (Nasdaq: BLUE) announced today that the company has placed its Phase 1/2 (HGB-206) and Phase 3 (HGB-210) studies of LentiGlobin gene therapy for sickle cell disease (SCD) (bb1111) on a temporary suspension due to a reported Suspected Unexpected Serious Adverse Reaction (SUSAR) of acute myeloid leukemia (AML).

In line with the clinical study protocols for HGB-206 and HGB-210, bluebird bio placed the studies on temporary suspension following a report received last week that a patient who was treated more than five years ago in Group A of HGB-206 was diagnosed with AML. The company is investigating the cause of this patient’s AML in order to determine if there is any relationship to the use of BB305 lentiviral vector in the manufacture of LentiGlobin gene therapy for SCD. In addition, a second SUSAR of myelodysplastic syndrome (MDS) in a patient from Group C of HGB-206 was reported last week to the company and is currently being investigated.

https://www.streetinsider.com/Corporate+News/bluebird+bio+%28BLUE%29+Announces+Temporary+Suspension+on+Phase+12+and+Phase+3+Studies+of+LentiGlobin+Gene+Therapy+for+Sickle+Cell+Disease/17973574.html

United Therapeutics Target Up to 'Street High' at OPCO on Physician Survey Results

 Oppenheimer analyst Hartaj Singh raised the price target on United Therapeutics Corp. (NASDAQ: UTHR) to a 'Street High' $275.00

https://www.streetinsider.com/Analyst+Comments/United+Therapeutics+Corp.+%28UTHR%29+PT+Raised+to+Street+High+%24275+at+Oppenheimer+Following+OPCO+Physician+Survey+Results/17973251.html

Hong Kong advisory panel OKs China's Sinovac COVID-19 vaccine for emergency use

 A Hong Kong government advisory panel on COVID-19 vaccines said on Tuesday it would recommend China's Sinovac vaccine for emergency use, a move that brings it a step closer to being formally greenlighted in the Asian financial hub.

Hong Kong's government said in early February that it was exempting Chinese drug maker Sinovac from publishing results of its third phase clinical trials in medical journals due to the "urgency" for vaccination.

The Pfizer/BioNTech vaccine – the first approved by Hong Kong's Health department - was required to have published results in a medical journal before being examined by the advisory panel.

The city's Health Secretary Sophia Chan has the final decision on whether to approve the Sinovac vaccine. 

https://www.marketscreener.com/quote/stock/SINOVAC-BIOTECH-LTD-5714593/news/Sinovac-Biotech-Hong-Kong-advisory-panel-approves-China-s-Sinovac-COVID-19-vaccine-for-emergency-u-32450120/