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Thursday, March 4, 2021

March medtech merger madness

 The medtech industry has really gone for it on the M&A front this year. 2021 started strongly, with more than $10bn-worth of deals announced in January alone; this week’s deals, notably Boston Scientific’s acquisition of Lumenis’s global surgical laser business for $1.1bn in cash, puts 2021’s total so far at $16.7bn.

In fact 2021 has had the strongest first quarter for device maker deal-making since 2016 – and the year is barely two months old. Should the rumoured takeover of Livanova by private equity for a price just shy of $4bn come off, 2021 could end up with the strongest opening period for a decade. 

Boston has been particularly keen this year, already buying the remote cardiac monitoring company Preventice in January for $925m up front. Its second even bigger deal will net it a portfolio of laser systems for urology and otolaryngology procedures, chiefly Lumenis’s Moses laser, used to break up kidney stones. Lumenis’s current owner, Baring Private Equity Asia, will keep Lumenis’s aesthetics and ophthalmology businesses.

Boston’s motivation for opening its chequebook is clear. The Covid-19 pandemic and its consequent lockdowns were catastrophic for the group, whose devices tend to be used in non-urgent procedures from which hospitals shied away so they could focus on coronavirus patients. A recent Evaluate Vantage analysis found that, out of the top 10 largest medtechs, Boston’s revenues sank the most in the fourth quarter of 2020 (Medtech’s haves and have-nots, February 24, 2021). 

Thus the company’s enthusiasm for buying high-growth businesses. Lumenis’s surgical unit expanded at double-digit rates in the five years before Covid-19 hit, and net sales are projected to hit $200m in 2021. Boston is likely to make more acquisitions throughout the year, though perhaps it might scale back to smaller tuck-ins. 

More to come

A second, smaller deal announced yesterday also has growth as its focus. Bio-Techne, which makes instruments and reagents for clinical diagnostics, bought Asuragen for $215m via a combination of cash and an existing line of credit. Asuragen specialises in genetic carrier screening for conditions such as Fragile X as well as oncology testing.

According to Leerink analysts, Asuragen’s sales are currently growing in the mid-teens annually, but Bio-Techne’s management reckons this can be upped to around 20%. It also intends to increase Asuragen’s operating margins to 40% over time. 

As impressive as the first quarter has been so far in terms of medtech M&A, another billion-dollar buyout could be on the cards. Yesterday shares in Livanova climbed 3% on rumours of an $80-per-share bid from the private equity group Permira that would value Livanova at around $3.7bn. 

Livanova has also been hit by the pandemic, with demand for its neuromodulators and heart valves taking a temporary knock. Its 2020 sales were down 14% compared with 2019 – an even greater drop than that experienced by Boston Scientific. Livanova ended up selling its valve franchise in December. 

The Permira deal is far from a sure thing. Livanova is often talked of as a takeover target – the last time rumours swirled, a year or so ago, the putative buyer was Medtronic. Analysts from Berenberg believe that Permira’s offer is too parsimonious to garner significant shareholder support, despite Livanova’s investor base being frustrated by its depressed near-term earnings, partly owing to its high R&D spend.

The analysts write that a strategic buyer makes more sense, since such a group could realise greater synergies than a PE shop, and believe a price of around $100 per share could get a deal done. Still, they add that there are few obvious signs of strategic interest.

If Livanova is claimed by Permira or anyone else, the first quarter of 2021 will set the year up to be a record-breaker.

Total Q1 M&A value ($m)First quarter M&A20122013201420152016201720182019202020210510152025Pure-play medtech deals only. Source: EvaluateMedTech.2014 Q1 M&amp: 11.4


EU and Italy Block Export of AstraZeneca Covid-19 Vaccine Doses

 Italy blocked the export of AstraZeneca PLC's Covid-19 vaccines to Australia, according to people familiar with the matter, in a move coordinated with European Union authorities, reflecting mounting frustration in Europe with slow deliveries of vaccines.

The move was prompted by the unsatisfactory compliance by the drug supplier with supply contracts, one of the people said.

Due to the current shortage of vaccine doses in the EU, it made sense to keep the shots in Italy, the person said. The 250,000 affected doses were bottled at a factory near Rome that is part of AstraZeneca's supply chain.

Representatives for AstraZeneca declined to comment.

The move is the first known use of a new EU policy that allows controls to be imposed on the export of Covid-19 vaccines.

In accordance with the EU policy, AstraZeneca had asked the Italian government for permission to export the doses. Rome refused and the European Commission supported the Italian government's decision, the people familiar with the matter said.

https://www.marketscreener.com/quote/stock/ASTRAZENECA-PLC-4000930/news/AstraZeneca-nbsp-EU-and-Italy-Block-Export-of-AstraZeneca-Covid-19-Vaccine-Doses-Update-32607369/

WHO investigators to scrap interim report on probe of COVID-19 origins

 A World Health Organization team investigating the origins of COVID-19 is planning to scrap an interim report on its recent mission to China amid mounting tensions between Beijing and Washington over the investigation and an appeal from one international group of scientists for a new probe, the Wall Street Journal reported on.wsj.com/388QK6F on Thursday.

In Geneva, WHO spokesman Tarik Jasarevic said in an email reply: “The full report is expected in coming weeks”.

No further information was immediately available about the reasons for the delay in publishing the findings of the WHO-led mission to the central Chinese city of Wuhan, where the first human cases of COVID-19 were detected in late 2019.China refused to give raw data on early COVID-19 cases to a WHO-led team probing the origins of the pandemic, Dominic Dwyer, one of the team’s investigators said last month, potentially complicating efforts to understand how the outbreak began.

The probe had been plagued by delays, concern over access and bickering between Beijing and Washington, which accused China of hiding the extent of the initial outbreak and criticised the terms of the visit, under which Chinese experts conducted the first phase of research.

The team, which arrived in China in January and spent four weeks looking into the origins of the outbreak, was limited to visits organised by their Chinese hosts and prevented from contact with community members, due to health restrictions. The first two weeks were spent in hotel quarantine.

https://www.reuters.com/article/us-health-coronavirus-who-china/who-investigators-to-scrap-interim-report-on-probe-of-covid-19-origins-wsj-idUSKBN2AW1US

Anthem upped to Buy from Hold by Truist

 Target to $375 from $360

https://finviz.com/quote.ashx?t=ANTM

KemPharm cut to Neutral from Buy by Wainwright

 Target to $12 from $24

https://finviz.com/quote.ashx?t=KMPH

Moderna, IBM team up on COVID-19 vaccine distribution data

 Vaccine maker Moderna Inc and IBM Corp said on Thursday they would work together on technologies to track COVID-19 vaccine administration.

The companies will focus on using technology to help governments and healthcare providers address potential supply chain disruptions through information sharing.

Organizations can also use IBM's Digital Health Pass tool to verify health credentials of employees, customers and travelers, according to a joint statement.

Earlier this year, Salesforce.com Inc, as part of a large coalition to digitize COVID-19 vaccination records, said it was launching a new product to help governments and healthcare providers maintain and manage such records.

https://finance.yahoo.com/news/moderna-ibm-team-covid-19-172349454.html

Israel, Austria and Denmark establish vaccine-supply alliance

  Israel, Austria and Denmark said on Thursday they would set up a joint research and development fund and possibly production facilities for COVID-19 vaccines to ensure they had long-term supplies for booster shots or to contend with virus mutations.

European Union members Austria and Denmark have been chafing at delays in ordering, approving and distributing vaccines within here 27-member bloc that have left it trailing far behind Israel's world-beating vaccination campaign.

After hosting his Austrian and Danish counterparts for talks and a tour of an Israeli gym open to those documented as having been vaccinated or recovered from COVID-19 with presumed immunity, Prime Minister Benjamin Netanyahu announced the pact.

“Once we get over this cycle of the disease we have no guarantee that it won’t come back. We don’t know how long - nobody knows - how long these vaccines will hold up,” he said at a joint news conference. “And therefore we have to protect our people against the reemergence of this pandemic or mutations.”

Austria’s Sebastian Kurz said he was “very happy” about an EU vaccine initiative “but we also need to cooperate worldwide”.

The European Commission has said member states were free to strike separate deals should they wish to.

The trilateral pact, Kurz said, would include investment in production plants in Europe and Israel, and each country contributing where it best can to the manufacturing cycle.

“In Austria, for example, lipid production necessary for many vaccines is already taking place,” the chancellor said.

Danish Prime Minister Mette Frederiksen said her country was looking to expand its production capacity. “We would like in common also to explore possible cooperation on clinical trials” with Israel and Austria, she said.

Netanyahu, who said 90% of eligible Israelis have either received at least one dose of the Pfizer/BioNTech vaccine or recovered from the virus, has made the programme a showcase of his campaign for a March 23 election.

“We will be, together, ‘Vaccination Nations’,” he said of the deal with Austria and Denmark. “And we agreed that if other nations want to join us, we will discuss this among ourselves and welcome others to come in as well.”

https://www.reuters.com/article/us-health-coronavirus-israel-vaccine-eur/israel-austria-and-denmark-establish-vaccine-supply-alliance-idUSKBN2AW250