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Monday, October 25, 2021

China locks down thousands as Delta flare-up spirals into nationwide surge

 China warned that new infections will increase in the coming days after the latest outbreak, which is fueled by the Delta variant, expanded to 11 provinces.

China locked down a county that has seen the most Covid-19 cases in the country’s latest Delta outbreak, as an initial flare-up in the northwest quickly spirals into a nationwide surge.

Ejin, a county in northwestern China’s Inner Mongolia, has asked its 35,700 residents to stay home from Monday and warned of civil and criminal liabilities should anyone disobey the order, state broadcaster CCTV reported, citing a local government statement. The small county bordering Mongolia is the current outbreak’s hotspot, home to nearly one-third of the more than 150 infections found over the past week in the mainland.

The lockdown came a day after a warning from National Health Commission officials that the outbreak would continue to worsen after spreading to 11 provinces in about a week. China reported 38 Covid infections on Monday, half of which were found in Inner Mongolia.

Earlier on Sunday, Beijing authorities announced the city is halting cross-province tourism and closing card and majhong rooms. China’s capital will also cut the number of large events and increase supervision over small clinics and pharmacies, according to the official WeChat account of the Beijing Municipal Health Commission.

https://businessmirror.com.ph/2021/10/25/china-locks-down-thousands-as-delta-flare-up-spirals-into-nationwide-surge/

40 Million in U.S. Had a Substance Use Disorder in 2020

 More than 40 million Americans were living with a substance use disorder in 2020, Capt. Michael King, PhD, MSW, of the Substance Abuse and Mental Health Services Administration (SAMHSA) said Monday.

King was reporting on the results of the SAMHSA annual National Survey on Drug Use and Health for 2020. "Many longstanding behavioral health problems are still here and are possibly getting worse," King, who is acting director of SAMHSA's Center for Behavioral Health Statistics and Quality, said on a phone call with reporters. And although the 40 million figure represents a doubling from 2019's estimate of 20 million, King cautioned that "the difference is most likely due to one of the changes in how we conduct our survey and it was a planned change, long in coming -- a change in the diagnostic criteria manual from the DSM-4 to DSM-5. In addition, many of our other methodological changes impacted this number more than likely, so while the number appears much larger, there are many caveats to that."

In terms of mental health, the survey found that 21% of adults -- almost 53 million people -- were classified as having any mental illness, and nearly 6% of the population, or 14 million, had a serious mental illness in the last year, King said. In terms of youth suicide -- the first year the report asked about this issue -- 12% of adolescents had serious thoughts of suicide, 5% had a plan, and 2% attempted suicide in the past year.

SAMHSA continues to make special efforts to include race and ethnicity data in its findings, according to King. "For example, one of the findings that stands out is that among people reporting two or more races, 11%, or just over half a million people, had serious thoughts of suicide, 3% had a suicide plan, and about 1% attempted suicide in the past year," he said, while "among Hispanic or Latino adults, 4%, or nearly 2 million people, had serious thoughts of suicide, 1% had a plan, and about 0.5% had attempted suicide in the past year."

"From a service perspective, our data clearly shows that treatment gaps remain for all of these people," he continued. "Consistent with the prevalence of substance use disorder (SUD), we found that 41 million people were classified as needing substance use treatment, and from a mental health perspective, less than half of the adults with any mental illness -- approximately 46% of them -- actually received any mental health services." And the situation was much worse for those with coexisting SUD and any mental illness: less than 6% of those people actually received services for both, King said.

This survey was the first to ask about vaping; results showed that while most older nicotine users -- approximately 88% -- use only tobacco products like cigarettes, nearly two-thirds of adolescents who were vaping didn't use any other tobacco products, "which shows you what the impact of vaping is," he said.

Other survey findings included:

  • In 2020, 21.4% of people ages 12 or older (or 59.3 million people) used illicit drugs in the past year, including 17.9% (or 49.6 million people) who used marijuana. In terms of age, the percentage of people who used marijuana in the past year was highest among young adults ages 18 to 25 (34.5%) compared with 16.3% of those ages 26 or older and 10.1% of adolescents ages 12 to 17.
  • Among people ages 12 or older in 2020, 3.4% (or 9.5 million people) misused opioids in the past year. Among the 9.5 million people who misused opioids in the past year, 9.3 million people misused prescription pain relievers and 902,000 people used heroin.
  • As far as new substance use was concerned, 1.3 million people in 2020 initiated cigarette smoking, 4.1 million initiated alcohol use, 2.8 million initiated marijuana use, and 1.2 million initiated prescription pain reliever misuse in the past year. The vast majority of people who were past-year initiates of cigarette smoking or alcohol use tried cigarettes or alcohol for the first time before age 26.

The survey is usually based exclusively on data from in-person interviews of 70,000 randomly selected people ages 12 and over; however, due to the pandemic, surveyors were only able to collect data for half of the year -- specifically quarter 1 and quarter 4 -- so the number of interviews for 2020 is only about 35,000. In addition, "we had to add new web survey methods and new content to help assess the impact of the ongoing pandemic," King noted.

https://www.medpagetoday.com/psychiatry/addictions/95249

NYC workers protest vax mandate with march across Brooklyn Bridge

 City workers took to the streets Monday to protest Mayor Bill de Blasio’s vaccine mandate for the entire municipal workforce.

Days after the mayor announced that all government employees except for jail staff will need to receive a vaccine shot by Friday or be placed on unpaid leave, about 5,000 incensed demonstrators marched over the Brooklyn Bridge to Manhattan.

Many carried American flags, chanting, “F–k de Blasio” and “We will not comply!”

Some protesters wore NYPD and FDNY shirts, and several hoisted Gadsden “Don’t Tread on Me” flags, while others took to the extreme of wearing yellow stars of David to compare the inoculation requirement to Nazi Germany’s persecution of Jews.

“Now, [after] working after countless of emergencies — Hurricane Sandy, the snowstorms … I am under threat. We are under threat of losing our livelihood for simply retaining the choice of protecting our bodies,” fumed firefighter Sofia Medina after the crowd reached City Hall.  

The large crowd of people protesting the city's COVID-19 vaccine mandate for municipal workers on October 25, 2021.
The large crowd of people protesting the city’s COVID-19 vaccine mandate for municipal workers on October 25, 2021.
Gregory P. Mango
About 5,000 demonstrators crossed the Brooklyn Bridge from Brooklyn into Manhattan.
About 5,000 demonstrators crossed the Brooklyn Bridge from Brooklyn into Manhattan.
Gregory P. Mango

“Why now are we being bribed and coerced to take a medication. … We are not now nor have ever been a public health threat.” 

“Leave us alone and let us work,” she said to de Blasio. “Get out of the way for those of us who want to work and show up on time.”

“Mayor de Blasio wants to paint us as immoral, unsafe, and a danger to the public. To the citizens of the city, we want to continue protecting you,” bellowed 
Paul Schweit, who was wearing an FDNY shirt.

A sign comparing President Joe Biden and Mayor Bill de Blasio to Adolf Hitler.
A sign comparing President Biden and Mayor Bill de Blasio to Adolf Hitler.
Rainmaker Photos/MediaPunch
A man with a sign calling the mandates "tyranny."
A man with a sign calling the mandates “tyranny.”
Rainmaker Photos/MediaPunch

“Thousands of good cops and city municipal workers stand to lose their jobs,” said a police officer. “Are the good people of New York City confident adequate people will fill those positions. I’m frightened of what comes next?”

The cop wondered, “Under the authority of Mayor de Blasio, what will be the next order for the NYPD?”

Mayoral candidate Curtis Sliwa at the vaccine mandate protest.
Mayoral candidate Curtis Sliwa at the vaccine mandate protest.
Rainmaker Photos/MediaPunch
A sign at the protest representing various city departments.
A sign at the protest representing various city departments.
Rainmaker Photos/MediaPunch

Another member of the city’s police force addressed NYPD Commissioner Dermot Shea, who supports a vaccine mandate.

“To Police Commissioner Shea: We have always been prepared to lay down our lives in defense of ours, will you run to our aid or stand idly by?” said a male cop, addressing the protesters.

The protest against City Hall’s new policy comes after de Blasio on Wednesday announced that the test-or-shot requirement would be replaced by an outright vaccine rule.

City employees — including firefighters and cops — will be mandated to get their first dose by 5 p.m. Friday, the mayor said. Members of the city workforce who have not started their vaccine series by Nov. 1 will be placed on unpaid leave until they provide proof of vaccination.

Demonstrators waving American flags at the protest against vaccine mandates in New York City.
Demonstrators waving American flags at the protest against vaccine mandates in New York City.
Rainmaker Photos/MediaPunch
A man holding a sign warning the city workers will "not comply" with the mandate.
A man holding a sign warning the city workers will “not comply” with the mandate.
Rainmaker Photos/MediaPunch

Previously, only Department of Education staff and city health workers were required to be inoculated against COVID-19.

As an incentive, holdouts who agree to receive a jab will get a $500 paycheck boost.

Correction officers have until Dec. 1 to receive their first shot, due to an ongoing staffing shortage at the beleaguered Rikers Island.

A woman with a sign protesting vaccine mandates for "essential" workers.
A woman with a sign protesting vaccine mandates for “essential” workers.
Rainmaker Photos/MediaPunch

Some city workers who already got their shots told The Post they viewed not receiving the hundreds of dollars reward as a sign of “disrespect.”

The demonstration follows a mob of anti-vaxxers gathering outside the Barclays Center on Sunday to support Nets star Kyrie Irving, whom the team is not allowing to play because he has not yet been vaccinated.

https://nypost.com/2021/10/25/we-will-not-comply-nyc-workers-protest-vax-mandate-with-march-across-brooklyn-bridge/

White House details new international travel rules

 The Biden administration outlined on Monday very narrow exemptions that will permit unvaccinated international travelers to enter the United States. 

Anyone who is under the age of 18 traveling from overseas will need to show a negative COVID-19 test before boarding a flight, but are exempted from vaccination requirements, the White House said.

Even though there are vaccines available in the U.S. to children as young as 12, administration officials said they are sensitive to the global variability regarding access to vaccination for older children who are otherwise eligible to be vaccinated. 

Similarly, the White House said people who are traveling on non-tourist visas from countries that have vaccinated less than 10 percent of their population are also exempt from the vaccine requirement. There are more than 50 countries that meet that threshold, including much of Africa, according to the World Health Organization.

A senior administration official said those individuals would need to show a "compelling reason" for traveling to the U.S.

"They need to have a specific, compelling reason. So, tourist visas will not qualify for that," the official said. If they qualify, they need to show proof of a negative test taken within 24 hours prior to departure.

Other exemptions include those with certain medical conditions, clinical trial participants and those traveling on short notice for emergency or humanitarian reasons, the official said.

Most non-U.S. citizens and nonimmigrants arriving into the country by air will need to show both proof of vaccination and proof of a negative coronavirus test taken at least three days before departure.

The administration initially outlined the new rules for international travel in September, including a rule that unvaccinated Americans will need to provide proof of a negative coronavirus test taken no more than 24 hours prior to departure.

There will be no quarantine requirement, but airlines will collect data for enhanced contact tracing. Airlines will also be the primary enforcers for the testing and vaccination requirements.

Digital and paper proof will be accepted, provided they meet Centers for Disease Control and Prevention specifications and show the person was fully vaccinated. The definition of "fully vaccinated" means at least two weeks after receiving the final dose, whether its a single dose or two-dose vaccine.

The CDC definition does not include proof of recent infection, with or without a vaccine.

"Initially there may be things that are more manual in nature and perhaps more paper. But as carriers are able to bring online more digital systems, we probably will see the use of those types of systems increase," a senior administration official said. 

The U.S. will accept any of the vaccines authorized for emergency use by the World Health Organization even if they are not cleared in the U.S., including Russian and Chinese vaccines.

https://thehill.com/homenews/administration/578343-white-house-details-new-international-travel-rules

Manchin shutting down Sanders on Medicare expansion

 Sen. Joe Manchin (D-W.Va.) on Monday shut down one of Senate Budget Committee Chairman Bernie Sanders's (I-Vt.) biggest priorities, expanding Medicare, which Manchin warned would undermine the solvency of the broader program.

Sanders insisted in a tweet Saturday that his proposal to expand Medicare to cover dental, hearing and vision must be included in a budget reconciliation package that is likely to come in well below the $3.5 trillion price tag Democratic leaders initially envisioned.

But Manchin on Monday threw cold water on Sanders’s push to expand Medicare, warning the program faces insolvency in 2026.

“My big concern right now is the 2026 deadline [for] Medicare insolvency and if no one’s concerned about that, I’ve got people — that’s a lifeline. Medicare and Social Security is a lifeline for people back in West Virginia, most people around the country,” Manchin warned.

“You’ve got to stabilize that first before you look at basically expansion. So if we’re not being fiscally responsible, that’s a concern,” he added.

That’s going to cause a problem with Sanders, whose vote is also essential to getting the budget reconciliation bill passed through the 50-50 Senate.

“The expansion of Medicare to cover dental, hearing and vision is one of the most popular and important provisions in the entire reconciliation bill. It’s what the American people want. It’s not coming out,” Sanders tweeted over the weekend.

But Medicare’s board of trustees warned in a report to Congress at the end of August that the estimated depletion date for Medicare’s hospital insurance trust fund is 2026. Furthermore, spending on Medicare is expected to rise from 4 percent of gross domestic product to 6.2 percent by 2045.

Manchin raised Medicare’s dim fiscal future as a major concern and a big reason not to expand it now, when the federal budget deficit is expected to hit $3 trillion for this year alone, according to the Congressional Budget Office.

“I’ve always said that I believe that government should be your best partner, but it shouldn’t be your provider. We have a moral obligation to provide to those who have incapacities such as physical or mental. But everyone else should be able to help and chip in and all that. So that’s my mindset,” he said.

Manchin also raised concern about a proposal being pushed by Sens. Raphael Warnock (D-Ga.) and Jon Ossoff (D-Ga.) to create a new Medicaid-style program to extend health insurance benefits to low-income people in states that didn’t expand Medicaid coverage under the Affordable Care Act.

Manchin said he felt the proposal would be unfair to states such as West Virginia that expanded Medicaid coverage under the Affordable Care Act but have to pick up 10 percent of the added cost of expanding the program.

He said that under the Warnock-Ossoff proposal, states participating in the new program wouldn’t have to pick up any cost. “I’m trying to understand that better,” he said.

Manchin argued that the states that opted out of the Affordable Care Act’s expansion of Medicaid could still participate in the program.

“There’s an understanding that we’re trying to look at that in a way is not an expansion. It’s basically a service, it’s so supposed to be all 50 states,” he said.

He argued that it would be unfair for states that declined to participate in the Affordable Care Act’s Medicaid expansion to get all of their costs covered by the federal government.

“The problem with that one right now we’re paying 90-10. So 10 percent is being paid for all the states. For states that held out to be rewarded 100 percent is not fair,” he said. 

https://thehill.com/policy/healthcare/578319-manchin-shutting-down-sanders-on-medicare-expansion

Cardinal Health expands solutions to mitigate missed cancer screenings

Cardinal Health (NYSE: CAH) announced today its cancer screening offerings from FUJIFILM Healthcare Americas Corporation and Polymedco that can be done either outside of a doctor's office or with less invasive procedures can help combat the increase in cancer-related deaths due to late-stage diagnoses1 from pandemic-related delays.

"The pandemic has changed the landscape of traditional diagnostic methods and is driving the healthcare industry to evaluate screenings differently," added Chris Kerski, general manager and senior vice president of Cardinal Health Laboratory Products. "We're adding new testing solutions to our portfolio to reduce barriers to screening and support patient-led cancer screenings."

Colon Cancer

According to a report in JAMA Oncology2, nearly 10 million cancer screenings for breast, colon and prostate cancer were missed in the U.S. since the pandemic began. Researchers recently reported a more than 40% decline in colon cancer diagnoses alone during the pandemic, a statistic that points to missed screenings, not fewer cases3.

"A missed screening increases the likelihood of a late-stage cancer diagnosis, which is associated with poor prognosis," says Nicholas Sullivan, Ph.D., a senior product manager at Cardinal Health Laboratory Products with a background in cancer biology and clinical laboratory medicine. "This high number of missed screenings during the pandemic has the potential to impact cancer patient outcomes for years."

During the pandemic, some health systems and health plans began proactively mailing screening collection kits to patients, rather than waiting for patients to come in for a routine visit or colonoscopy4. Cardinal Health works with Polymedco to offer OC-Auto®FIT, which detects small amounts of blood in stool – an early indication of colon cancer5. Different than a colonoscopy, patients don't have to prep in advance of the test and can do the stool specimen collection at home.

Liver Cancer

Liver cancer is one of the top-three leading causes of cancer-related deaths worldwide6 accounting for more than 700,000 deaths each year7.

In November 2020, Cardinal Health became the first distributor of Fujifilm's innovative solution, the ÂµTASWako® i30 Immunoanalyzer System testing for liver biomarkers AFP-L3 and DCP using a simple blood draw. These biomarkers aid in the risk assessment of patients with chronic liver disease for the development of hepatocellular carcinoma (HCC), the most common type of liver cancer8.

HCC surveillance is critical for those at-risk for liver cancer given its lethality. A recent study9 reported that liver cancer surveillance dramatically declined during the pandemic and that "a delay of just a few months in HCC surveillance may be catastrophic for patients, given that the doubling time for HCC tumor volume is 85.7 days." Only 20% of those patients at risk of developing liver cancer receive surveillance10.

Cardinal Health now offers Fujifilm's automated solution to enhance clinical lab customers' liver surveillance cancer programs.

https://finance.yahoo.com/news/cardinal-health-expands-solutions-mitigate-152000848.html

EryTech Misses Primary Endpoint in Pancreatic Cancer Phase 3 Trial

 

  • The trial did not meet its primary endpoint of overall survival

  • The prespecified subgroup of patients treated with eryaspase and an irinotecan-based chemotherapy demonstrated an interesting trend of survival benefitwhich merits further investigation

  • Patients treated with eryaspase demonstrated superior disease control compared to patients treated with chemotherapy only. Other secondary endpoints showed nominal improvement

  • The safety profile of eryaspase was consistent with earlier clinical trials results and safety reviews

  • ERYTECH will now focus on its late-stage program in hypersensitive ALL and confirms its intention to submit a BLA before the end of the year

  • ERYTECH will review strategic and partnering alternatives, including for the further development and commercialization of eryaspase

Management to host Conference Call on Monday, October 25,
at 8:30am EDT/ 2:30pm CEST

TRYbeCA-1 Top-line Results and Analysis Conference Call Details

ERYTECH management will hold a conference call and webcast on October 25, at 8:30am EDT / 2:30 pm CEST highlights the top-line results and plans for future approval and launch in 2022. Gil Beyen, CEO, Eric Soyer, CFO/COO, and Iman El-Hariry, CMO, will deliver a brief presentation, followed by a Q&A session.

An archive of the webcast will be available on ERYTECH’s website, under the “Investors” section at investors.erytech.com

An archived replay of the audio call will be available for 7 days by dialing + 1 855 859 2056, Conference ID: 2361482#.

https://finance.yahoo.com/news/erytech-announces-results-trybeca-1-050000479.html