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Wednesday, February 9, 2022

100M new COVID-19 cases reported in less than a month worldwide

 The world saw 100 million COVID-19 cases in just the past month amid the spread of the extremely infectious omicron variant. 

On Tuesday, the world reached more than 400 million known coronavirus cases, just a month after hitting 300 million, according to The New York Times.

The already-high figures are almost certainly an undercount given that many at-home positive rapid test results are not included in the count and not all people infected with the virus are tested for a variety of reasons. 

Though cases were still pervasive at the beginning of the pandemic, it took more than a year since the first detection of a COVID-19 case for the globe to see its first 100 million cases, a milestone reached in January 2021. The next 100 million cases came in a shorter time frame of about seven months, the Times added. 

Despite the record-setting milestone, daily case numbers have started to decline after an overwhelming surge in infections fueled by omicron.

The Biden administration’s chief medical adviser Anthony Fauci said on Tuesday that the country is moving away from the “full-blown” pandemic phase.

“As we get out of the full-blown pandemic phase of COVID-19,” Fauci said, discussing policy, “which we are certainly heading out of, these decisions will increasingly be made on a local level rather than centrally decided or mandated. There will also be more people making their own decisions on how they want to deal with the virus.”

https://thehill.com/policy/healthcare/593462-100m-new-covid-19-cases-reported-in-less-than-a-month-worldwide

Biden caught between CDC and Democratic governors on COVID-19

 Biden is being put in a difficult spot on COVID-19 — and this time he can thank Democratic-led states for the conundrum. 

Four states, all of which have Democratic governors, have announced in recent days that they are going to lift mask mandates for schools. Separately, deep-blue California is going to end its policy of requiring vaccinated people to mask while indoors next week. 

But the Biden administration has promised to follow the guidance of scientists, specifically those at the Centers for Disease Control and Prevention (CDC). The CDC has not yet issued any change to its guidance on masking. 

That leaves Biden in a bind.  

The White House risks looking overly cautious on restrictions if it sticks with the status quo — a dangerous political position in a nation that has grown frustrated and restless after two years of pandemic restrictions. 

On the other hand, the White House doesn’t want to sound an all-clear that turns out to be premature. 

It knows how dangerous that can be. 

Biden’s July 2021 declaration, timed to coincide with the Independence Day holiday, that the nation was on the verge of being able “to declare our independence from a deadly virus” has come to be seen in retrospect as one of his worst moments in the fight against COVID-19. 

A May 2021 announcement from CDC Director Rochelle Walensky that vaccinated people could stop wearing masks was not much better. The call had to be reversed just two months later. 

White House press secretary Jen Psaki pushed back when asked at Tuesday’s media briefing about the apparent discrepancy between the administration’s position and that of California as well as the states that are lifting school mask mandates: Connecticut, Delaware, New Jersey and Oregon. 

“We don’t look at it through that prism,” Psaki responded, when asked if the states were, in effect, overruling the CDC. 

As to whether or when the administration’s position would change, Psaki responded: “You’ll have to ask the CDC. The CDC moves at the pace of data and science.” 

Even public health experts understand the political dilemma that the president and his aides are in. 

“I think there is a huge political risk to the CDC and the White House,” Lawrence Gostin, a Georgetown University professor and expert on global health law, told this column.  

“Already you are seeing a large swath of public opinion opposing CDC ‘dictating’ mandates. They see the case numbers plummeting and they see Democratic governors lifting mandates. There is enormous political peril for the White House.” 

Yet, at the same time, Gostin and others in public health understand the need to tread warily. The professor said that he believes it is premature to make sweeping changes to mandates, whether for children or the population at large. 

He cited three factors: the risk of the receding omicron wave becoming resurgent if the public lets its guard down; the fact that hospitals remain overburdened and have built up a serious backlog for non-coronavirus treatments; and the relative scarcity of monoclonal antibody treatments and effective oral antiviral medication for those unfortunate enough to be stricken by COVID-19. 

“We have made the same mistake time and time again for the past two years,” Gostin lamented. “As soon as there is a ray of hope we lift everything — and the plague rains down on our head again.” 

Other public health experts echoed that sentiment. 

“I don’t see the data supporting that decision,” professor Odis Johnson, executive director of the Johns Hopkins Center for Safe and Healthy Schools, told this column, referring to the lifting of school mask mandates.  

Asked whether he thought the governors who were lifting such mandates were bowing to political pressure, he responded: “That is the only conclusion I can draw, especially since the CDC has largely been silent … Without that guidance, I have no clue why they think now is the perfect time.” 

Even so, the political pressure is intense. The omicron-driven surge in new COVID-19 cases is falling rapidly. There is increasing public discussion of the damage that may have been done to children, both emotionally and educationally, by the disruptions of the past two years. And the general public is desperate to move on. 

In an Economist/YouGov poll released last week, 36 percent of Americans asserted that “the worst part of the pandemic” is behind us, almost twice as many as the 19 percent who predicted it “is going to get worse” — and infection rates have dropped even more sharply since then. 

That is the kind of sentiment some of the Democratic governors may be reacting to as they lift mandates.  

New Jersey Gov. Phil Murphy (D) announced that schools could lift their mandates in his state beginning March 7, calling the move “a huge step back to normalcy.”  

Experts like Gostin understand public sentiment — but want the public and political leaders to sustain restrictions just a little longer. 

“If I were a governor I’d say, ‘We are really optimistic that all of these trappings of the pandemic that are affecting your life and have made you unhappy for so long are going to be lifted. But not until we have assurances that the case rate is going to go down and stay low, the hospitals are going to be at normal capacity and we are going to have effective life-saving treatments widely available. Just hold on,’ ” he said. 

The problem, for governors and perhaps for the president too, is that “just hold on” may no longer be a sellable political message. 

https://thehill.com/homenews/the-memo/593381-the-memo-biden-caught-between-cdc-and-democratic-governors-on-covid-19

Mass. school mask mandate to be lifted at end of month

 Massachusetts will lift its statewide mask mandate for schools at the end of this month, Gov. Charlie Baker (R) announced on Wednesday.

"With Massachusetts a national leader in vaccinating kids, combined with our robust testing programs, it is time to lift the mask mandate in schools and give students and staff a sense of normalcy after dealing with enormous challenges over the past two years," Baker said in a statement at his COVID-19 briefing.

He added that the state has "all the tools to keep schools safe as we move into dealing with the next phase of managing COVID."

"COVID, like many other respiratory diseases, will be with us for the foreseeable future," Baker said, but added "thankfully the advances in vaccines, treatments and testing are mitigating the harm cause by COVID."

The Department of Elementary and Secondary Education Commissioner (DESE) Jeffrey C. Riley said "removing the mask requirement will make it easier for students to learn, particularly our young readers and students learning English as a second language," according to The Boston Globe.

However he added, "While masking is no longer a statewide requirement, we ask all school leaders and students to make sure they respect all individual choices around mask wearing."

The decision to lift the requirement was made in consultation with infectious disease physicians, the DPH, and other medical experts, according to DESE, 7 Boston News reported.

New Jersey, Delaware, Connecticut and Oregon on Monday announced that mask mandates affecting schools and students will be phased out in the coming months.

New York Gov. Kathy Hochul (D) is expected to announce on Wednesday that the state will lift its indoor mask mandate for businesses. 

https://thehill.com/homenews/state-watch/593479-massachusetts-school-mask-mandate-to-be-lifted-at-end-of-month

Fauci: US exiting 'full-blown' pandemic phase of coronavirus crisis

 The U.S. is exiting the “full-blown” pandemic phase of the years-long COVID-19 crisis that began in 2020, the Biden administration’s chief medical adviser Anthony Fauci told the Financial Times on Tuesday.

Fauci, who is the director of the National Institute of Allergy and Infectious Diseases, said that new developments that limit COVID-19, including vaccinations, medical treatments and prior infection, will alter the pandemic situation significantly in the coming months.

“As we get out of the full-blown pandemic phase of COVID-19,” Fauci said to the Times. “Which we are certainly heading out of, these decisions will increasingly be made on a local level rather than centrally decided or mandated. There will also be more people making their own decisions on how they want to deal with the virus.”

Fauci said that he hopes all COVID-19 restrictions will be halted in the coming months as well, citing mandatory mask-wearing as one of the restrictions he expects to end. He agreed that restrictions might end in 2022.

Nonetheless, Fauci warned that local health departments might bring back certain restrictions if regional outbreaks occur.

“There is no way we are going to eradicate this virus,” said Fauci, according to the Times. “But I hope we are looking at a time when we have enough people vaccinated and enough people with protection from previous infection that the COVID restrictions will soon be a thing of the past.”

More than 900,000 Americans have died of COVID-19 since 2020. However, COVID-19 cases are currently rapidly decreasing.

https://thehill.com/policy/healthcare/593456-fauci-us-exiting-full-blown-pandemic-phase-of-coronavirus-crisis

New York To Ditch Indoor Mask Mandate While LA County Warns Its Could Remain For 'Weeks Or Months'

 New York Gov. Kathy Hochul is planning to lift the Empire State's mask mandate this week - what the NYT described as a "watershed moment" in New York's struggle against COVID - a decision that follows a similar move by NJ Gov. Phil Murphy made earlier this week.

According to an NYT preview of Hochul's decision (which she confirmed in an announcement released just before noon, in New York) the governor "was not swayed" by similar moves made by neighboring Democrat-controlled states (*cough* New Jersey *cough*) and is basing her decision "purely on the latest data and consultations with public health experts" - including her talks with Dr. Anthony Fauci.

On Tuesday, the governor became more comfortable with the latest metrics, which indicated that bed capacity at hospitals in the state was at about 4%, down from a peak of 23% on Jan. 2. As for masks in schools, Hochul says she will wait until March before she stops to reassess.

While NY is keeping its mask mandate in schools - for now, at least - Massachusetts has just decided that its school mask mandate will end on Feb. 28.

The decision will have a "far reaching" impact on public settings in the state, including businesses from retail shops to restaurants and malls - and workplaces as well.

Once Hochul's decision has been made, these places would no longer be required to enforce "mask-wearing" or ask for "proof of vaccination" unless they choose to do so on their own.

Unfortunately for students and their parents, Hochul's move wouldn't impact requirements that students and teachers wear masks at school. That decision is set to expire on Feb. 21, and it's unclear whether the governor wll move to extend it, or not.

"I am optimistic that we’re trending in that direction, but I still need the time," said Ms. Hochul, who met virtually with a group of school officials on Tuesday afternoon.

While plenty of New Yorkers will be relieved, in other states and counties, they haven't been as lucky. While California prepares to lift its indoor mask mandate next week, the state's most populous county - LA County - has established itself as a notable hold out, thanks to the decision-making skills of its "SJW" Director of the Department of Public Health, Barbara Ferrer.

Ferrer, who isn't a doctor and whose background focuses on health-care "access", not the actual provision of health-care, said yesterday that LA County will not follow the state's guidelines to lift masking mandates. Instead, the mandate will remain in effect for weeks, if not months, the Epoch Times reports.

Why? Well, Ferrer "clarified" the requirements for the county to drop the mask mandate for both outdoor and indoor spaces. To go mask-free outdoors, including mega-events, schools, and childcare facilities, the county has to be considered as "post-surge" - with less than 2,500 hospitalizations for seven consecutive days. In New York, the current 7-day hospitalization rate is roughly 2,900 patients. So, if that rate is "good enough" for the densely populated NYC (not to mention the rest of the state) to lift its masking requirements, why must LA County be any different?

Furthermore, Ferrer is insisting that vaccines must be available for children under 5 "for at least 8 weeks" before masking requirements are lifted. The jabs are expected to be approved for the youngest Americans by the end of this month.

That's bad news for anybody who plans on attending the Super Bowl, which will take place in Los Angeles this weekend.

In both NY and California, hospitalizations have fallen sharply in recent weeks.

First, here's New York:

Source: NYT

And now, California:

Source: LA Times

Looking at the US as a whole, COVID cases have plunged, while deaths have more or less plateaued.

And hospitalizations have fallen sharply.

That means people in LA County might be among the last in the country to see their indoor masking requirements shot down, even as omicron cases in the US have fallen dramatically.

https://www.zerohedge.com/covid-19/new-york-ditch-indoor-mask-mandate-while-la-county-refuses-do-so

CNN's 'Doctor': 'The Science Has Changed' So Lift COVID Restrictions

 by Steve Watson via Summit News,

Despite nothing changing at all, CNN’s resident ‘doctor’ Leana Wen claimed this week that “the science has changed” and so COVID restrictions including mask mandates should now be rescinded.

Wen failed to cite any studies or data that shows the science has changed.

Wen, who started to admit some weeks ago that masks don’t work in stopping the spread of COVID, stated that “the decision to wear a mask should shift from a government mandate to an individual choice.”

She added that kids in schools should not be forced to wear masks because it can be harmful and makes it harder for them to learn.

Watch:

As recently as two months ago, Wen was advocating for the Biden administration to “further restrict the activities of the unvaccinated.”

Wen also previously entrenched a segregated society when she blamed people who hadn’t taken the jab for a COVID-19 “surge” while asserting “we can’t trust the unvaccinated.”

Wen also called for making it “hard for people to remain unvaccinated” by restricting their social freedoms.

She asserted that, “It needs to be hard for people to remain unvaccinated,” claiming that it wasn’t currently difficult (despite the group being demonized and discriminated against on a daily basis).

Wen also previously stated that children returning to school need to be forced to wear industrial grade face masks and should be subjected to weekly COVID tests until they are fully vaccinated.

Suddenly all of this has changed for Wen.

It just happens to coincide with the beginning of election season, and Democrats now moving away from lockdown policies they previously vehemently advocated over fears about being wiped out politically.

https://www.zerohedge.com/political/cnn-doctor-science-has-changed-so-lift-covid-restrictions

Sweet success for Pfizer in diabetes

 Look out Novo Nordisk: early data suggest that Pfizer’s small-molecule GLP-1 agonist danuglipron could be a contender in diabetes. True, Pfizer still has a lot to do, but results with the highest dose tested in a phase 2 trial show promising HbA1c lowering and weight loss that, on a cross-trial basis, looks better than that seen with Novo’s oral GLP-1 Rybelsus. The project to beat now might be Lilly’s injectable GIP/GLP-1 agonist tirzepatide, and there is the possibility that danuglipron’s performance could improve, Pfizer’s chief scientific officer, Mikael Dolsten, suggested during the group’s fourth-quarter earnings call yesterday. First, the study was only 12 weeks long, and secondly Pfizer believes that it has yet to nail down the optimum dose titration. A new phase 2, looking at titration over up to a month, is due to start mid-year. Pfizer is already looking ahead of twice-daily danuglipron, and recently took a once-daily oral GLP-1, PF-07081532, into phase 1. However, this does not indicate a lack of faith in danuglipron, Mr Dolsten insisted: “I believe danuglipron has what it takes to go into a pivotal study.” The group might eventually test PF-07081532 and danuglipron in the same trial, he added.

Cross-trial comparison of data with GLP1-targeting projects
Project/productCompanyTrialHbA1c decreaseWeight loss
Danuglipron (PF-06882961) 200mg bidPfizerPh2 12-wk C34210081.6%5.4kg
Rybelsus (oral semaglutide)Novo NordiskPh3 26-week Pioneer 11.2-1.4%2.3-3.7kg
Ozempic (injected semaglutide)Novo NordiskPh3 30-wk Sustain 11.4-1.6%3.8-4.7kg
Tirzepatide*LillyPh3 40-wk Surpass-22.0-2.3%7.6-11.2kg
*Dual GIP/GLP-1 agonist. Source: Company presentation, product labels & NEJM article.

https://www.evaluate.com/vantage/articles/news/trial-results-snippets/sweet-success-pfizer-diabetes