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Sunday, January 14, 2024

89Bio Downgraded on Short-Term Uncertainties In Fatty Liver Drug Development

 RBC Capital Markets downgraded 89Bio Inc 

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, a clinical-stage biopharmaceutical company focused on developing and commercializing therapies for liver and cardio-metabolic diseases.

The analyst maintains a positive outlook on the long-term prospects of the FGF21 class drugs, considering it as a fundamental approach to addressing NASH (Non-Alcoholic Steatohepatitis) and other metabolic-related ailments. 

Additionally, RBC Capital is optimistic about ETNB’s pegozafermin (BIO89-100), which it sees as a strong contender in this space, particularly given recent favorable trial designs facilitated by the FDA

However, the analyst anticipates fewer short to medium-term clinical updates on pegozafermin that would materially de-risk or change the fundamental story. 

There is some uncertainty regarding how 2024 results for GLP-1 treatments and developments around the first entrant, Madrigal Pharmaceuticals Inc’s 

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 resmetirom, might impact perceptions of pegozafermin’s potential in treating NASH. 

The approaching March 14 PDUFA for Madrigal’s resmetirom might revive interest in the NASH sector. However, it could also underscore the oral medication’s approximately four-year advantage over pegozafermin.

RBC downgrades 89bio from Outperform to Sector Perform, with a price target of $15, down from $24.

A recent strategic decision to delay the severe hypertriglyceridemia (SHTG) filing until after the NASH phase 3 trial readout could diminish the immediate impact of next year’s initial pivotal SHTG results. 

The FDA’s guidance suggests an optimistic outlook for the progression of NASH treatment. However, the anticipated approval for the F2/F3 phase 3 data/acceleration is likely to occur around 2027/2028, indicating a more realistic timeline for the program’s development.

Additionally, heightened competition in the hypertriglyceridemia market may lead to ETNB shares trading more closely with industry norms in the near term.

https://www.benzinga.com/analyst-ratings/analyst-color/24/01/36616531/liver-disease-player-89bio-downgraded-analyst-sees-short-term-uncertainties-in-fatt

New Restrictions On Independent Contractors Could Destroy Gig Work

 by Karen Harned via RealClear Wire,

The gig economy has become a crucial part of our nation’s economic infrastructure. Beyond platforms like Uber and Lyft, independent contract workers are also vital to many other sectors of our economy, from healthcare to the arts. In fact, gig work provides at least part-time income to one in three American workers, totaling $1.2 trillion to the U.S. economy in annual earnings

But a new rule just issued by the Biden Administration will essentially ban independent contractor status for gig workers under the Fair Labor Standards Act. It will threaten a crucial source of livelihood for millions by putting these jobs at risk. For example, a recent study projected that this sort of policy would result in more than 73,000 lost app-based jobs in Massachusetts alone.

In the wake of successful wage negotiations by the United Auto Workers and other unions, the Biden Administration thinks these workers would be better off if they are converted to full-time employees who are eligible for union membership and traditional employee benefits. But that would destroy the flexibility and independence these workers value most.

A far better solution would be to allow companies to extend benefits to gig workers without making them employees and taking away their autonomy.

Workers in the gig economy have the freedom to set their own schedules and decide when and where they work. This flexibility is not just a perk; it’s a fundamental factor that contributes to high job satisfaction in this field. The Bureau of Labor Statistics found that 79% of independent workers prefer their current arrangements over traditional employment, which can take away their flexibility.

The new rule from the Department of Labor seems better suited for the economy of 1923 than 2023. Rather than going to the same shift every day, many independent workers complete tasks at odd hours they can squeeze in between parenting and other family obligations or as part-time work to supplement their regular income.

California’s recent failed attempt at this policy should also serve as a cautionary tale. The state’s law aimed to classify gig workers as traditional employees, but it led to job losses across the state. Small businesses like theaters and music venues were particularly hard hit. The ensuing bipartisan backlash led the state to later exempt 110 professions from the regulations.

It’s clear that a one-size-fits-all approach doesn’t work. However, there’s no doubt that the existing regulatory structures for work in the U.S. need to be overhauled to meet modern economic and labor requirements. 

Under current regulations, companies are not allowed to provide standard employment-based benefits such as paid time off, healthcare, and retirement plans to independent workers. If a company wants to provide benefits, they would have to convert them to regular employees. The workers would lose their independence and flexibility, forcing many to quit. 

Instead of banning independent contractors outright, we should give workers the choice to remain independent while giving companies the option to extend benefits if they want to do so. 

The easiest way to accomplish this would be to establish benefit savings accounts that would let companies extend special benefit bonuses to their contractors. Workers would then use these bonuses to pay for their own benefits on a tax-free basis. This would create a parallel structure that already lets companies pay for employee benefits without paying taxes on those expenses. And the plan lets contractors prioritize the benefits they want most.

Creating benefit savings accounts aligns with the interests of both gig workers and companies. For gig workers, it preserves their flexibility while offering a safety net of benefits. For companies, it allows them to attract and retain talent, promote worker loyalty, and contribute to the overall well-being of their workforce.

About 80% of gig workers say they want access to benefits like health insurance, and companies such as Uber are eager to provide them.

At least nine states have already introduced legislation to reform laws that prohibit companies from giving benefits to non-employees. Utah has been a leader on this issue, passing a law earlier this year to allow companies to provide benefits to independent contractors.

While this progress at the state level shows great potential, creating benefit savings accounts will require the federal government to make reforms too, so workers can use their benefit dollars without paying federal taxes.

By preserving flexibility and allowing benefits, we can uphold the core independence that fueled the growth of the gig economy while adapting to the evolving needs of its workforce in the 21st century. The Biden administration should reconsider its approach and work toward a more balanced solution that respects the choices and needs of millions of gig workers – and the businesses and consumers that rely on their services.

This article was originally published by RealClearPolitics and made available via RealClearWire.

Karen Harned is president of Harned Strategies LLC. From 2002 to 2022, she served as executive director of the National Federation of Independent Business Small Business Legal Center.

https://www.zerohedge.com/political/new-restrictions-independent-contractors-could-destroy-gig-work

Latest Congressional Can-Kick Delays Debt Ceiling Doom Until March

 You'll never guess what happened...

That's right, folks! Our wise and benevolent lawmakers have once again averted debt ceiling disaster - after lawmakers in the House and Senate reached a bipartisan spending deal that will extend two major deadlines and keep the government operating ... for six more weeks!

Until we get to do this all over again.

According to NBC News (so who knows), "The deal would keep the government funded until March, buying legislators more time to craft longer-term, agency-specific spending bills, following the agreement last weekend to set the overall spending level for fiscal year 2024 at $1.59 trillion."

The new agreement moves upcoming government funding deadlines for different departments from Jan. 19 and Feb. 2 to March 1 and March 8.

The short-term bill, known as a continuing resolution or “CR,” will need to pass both the House and Senate before Friday at 11:59 p.m. to avoid a partial government shutdown.

Speaker Mike Johnson is set to hold a call with fellow House Republicans at 8 p.m. Sunday to discuss spending negotiations. Several hard-right Republicans have objected to the top-line spending deal he previously cut with Senate Democrats and have urged Johnson to go back on it, though he said Friday that the agreement remains intact. -NBC News

"The bipartisan topline appropriations agreement clears the way for Congress to act over the next few weeks in order to maintain important funding priorities for the American people and avoid a government shutdown," said Chuck Schumer and Hakeem Jeffries - the top Democrats in both chambers.

Trump rallies Iowa voters via teleconference amid winter storm: Watch live

 


Former President Trump is set to hold a rally for Iowa voters via teleconference on Saturday evening, replacing two events the campaign canceled due to poor weather conditions in the Hawkeye State.

A powerful blizzard has put a freeze on campaign events, as candidates look to make their final case to Iowans ahead of Monday’s caucuses. 

Trump, who remains the GOP front-runner in the 2024 race, vowed that he would get to Iowa “one way or the other.”

The Hill/Decision Desk HQ average in Iowa shows Trump leading with 54.4 percent support, followed by former South Carolina Gov. Nikki Haley at 17.4 percent and Florida Gov. Ron DeSantis at 15.9 percent. 

Instead of the in-person events, the former president, alongside Iowa Attorney General Brenna Bird, will deliver remarks at 8 p.m. EST via video.

Watch the live event above.

https://thehill.com/video-clips/4407036-trump-rallies-iowa-voters-via-teleconference-watch-live/

Rand Paul says Fauci should ‘go to prison’ over COVID-19 ‘dishonesty’

 Sen. Rand Paul (R-Ky.) said that the former U.S. chief medical advisor, Dr. Anthony Fauci, should “go to prison” over his “dishonesty” in handling the COVID-19 pandemic and lying to Congress. 

“For his dishonesty, frankly, he should go to prison,” Paul said during a Sunday interview with radio host John Catsimatidis on “The Cats Roundtable” on WABC 770 AM. “If you lie to Congress, and you’re dishonest, and you won’t accept responsibility. For his mistake in judgment, he should just be pilloried. He should never be accepted.”

He added, “History should judge him as a deficient person who made one of the worst decisions in public health history — in the entire history of the world.”

The Kentucky Republican, who believes the virus came from a lab in China, accused Fauci of directly contributing to the deaths of “somewhere between 10 and 20 million” with his decision to “fund dangerous research – gain-of-function research, where you allow viruses to be combined.”

Paul and Fauci, who led much of the U.S. response to the COVID-19 pandemic, have a fiery history, with the Kentucky Republican repeatedly accusing the infectious disease expert of lying about the origins of the virus.

Paul’s Sunday comments echo similar ones he made last year when he said that the former White House chief medical advisor should “without question” be in jail.

Fauci, who became the target of intense scrutiny as the COVID-19 pandemic became politicized, previously shut down calls to prosecute him over his handling of the COVID-19 pandemic.

“There’s no response to that craziness,” Fauci said on CNN in March.

He added, “I mean, prosecute me for what? What are they talking about? I mean, I wish I could figure out what the heck they were talking about. I think they’re just going off the deep end,” Fauci said.

He also slammed the calls to jail him as “irresponsible.”

“It doesn’t make any sense to say something like that and it actually is irresponsible,” he said.

https://thehill.com/homenews/state-watch/4407600-rand-paul-says-fauci-should-go-to-prison-over-covid-19-dishonesty/

Almost half of Haley supporters say they would vote for Biden over Trump: Iowa Poll

 Just under half of likely Iowa GOP caucusgoers who support former UN Ambassador Nikki Haley indicated that they would make a crossover to the Democratic party, saying that they would rather vote for President Biden over former President Trump.

A new NBC News/Des Moines Register/Mediacom poll released just one day before the Iowa caucus found that 43 percent of Haley backers in the state said they would vote for Biden if Trump is the GOP nominee while 23 percent say they would vote for the former president. Nineteen percent said they would vote for Independent candidate Robert F. Kennedy, Jr.

Overall, 71 percent of likely GOP caucusgoers said they would vote for Trump in 2024 while only 11 percent said they would vote for Biden.

“Haley is consolidating the anti-Trump vote,” J. Ann Selzer, a pollster who conducted the Iowa survey over the last three decades, told NBC. “She does well with the people who define themselves as anti-Trump.”

The poll also explored likely Iowa GOP caucusgoers’ view of Trump’s legal challenges. Overall, 74 percent said Trump can win a general election despite his legal challenges, while 23 percent said it’s nearly impossible for him to win against Biden. Among Haley’s supporters, 54 percent said the former president wouldn’t be able to win, while 42 percent said he they believe he could.

The NBC News/Des Moines Register/Mediacom poll was conducted Jan. 7-12 of 705 likely Republican Iowa caucusgoers. The poll has an overall margin of error of plus-minus 3.7 percentage points. 

https://thehill.com/elections/4408071-almost-half-of-haley-supporters-say-they-would-vote-for-biden-over-trump-iowa-poll/

Southwest Airlines Deletes X Post Celebrating "All Female Flight Crew"

 by Paul Joseph Watson via Modernity.news,

Amidst questions surrounding whether ‘diversity and inclusion’ drives are jeopardizing airline safety, Southwest Airlines deleted a post on X celebrating an “all female flight crew.”